Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Sakshi Jain

MS, BDS

Reviewed By

Dr. Sachin Gupta

MD Pharmacology, MBBS

Last updated

16 Feb 2026 | 11:41 PM (IST)

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Four Derm AF Cream

Prescription Required

Marketer

Cipla Ltd

SALT COMPOSITION

Clobetasol (0.05% w/w) + Neomycin (0.5% w/w) + Miconazole (2% w/w) + Chlorocresol (0.1% w/w)

Storage

Store below 25°C

Click here to view all substitutes

Product introduction

Four Derm AF Cream is a combination of medicines that is used to treat various types of skin infections. It minimizes symptoms of inflammation such as redness, swelling, and itching. It also prevents the growth of infection-causing microorganisms to promote faster healing of infections.

Four Derm AF Cream is only meant for external use and should be used as advised by your doctor. A thin layer of the medicine should be applied only to the affected areas of the skin with clean and dry hands. If it gets into your eyes, nose, mouth or vagina rinse with water. It may take several days to weeks for your symptoms to improve, but you should keep using this medicine regularly. The course of the treatment should be completed to ensure better efficacy of the medicine. If your condition does not improve or gets worse, you should talk to your doctor.

The most common side effect of this medicine includes itching, skin thinning, irritation, and burning sensation at the application site. These are usually self-limiting. Regular application of moisturizer to the skin can help to overcome or prevent dryness of the skin, also you must drink plenty of water to keep yourself hydrated. Serious side effects are rare. You must consult the doctor if you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.).

Before using this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Pregnant and breastfeeding women should use this medicine with proper consultation and caution. If you are a known allergic to the medicine, you must refrain from using this medicine and consult the doctor about this condition. During the course of the treatment, do not touch or scratch the infected skin areas as this may worsen or spread the infection.

Uses of Four Derm AF Cream

Skin infections

Benefits of Four Derm AF Cream

In Skin infections

Four Derm AF Cream is a combination of medicines used to treat skin infections caused by microorganisms such as bacteria and fungi. It works by killing and stopping the growth of infection causing microorganisms, thereby clearing the infection and relieving the symptoms. It also blocks the release of chemicals that cause symptoms such as itching, redness and swelling. Therefore this medicine relieves the inflammation due to these infections.
You should use this medicine for as long as it is prescribed, even if your symptoms disappear, otherwise they may come back. Depending on the type of infection you are treating, this may be several weeks. Even after your skin is completely cured, you may have to apply it occasionally to prevent the symptoms from returning.

Side effects of Four Derm AF Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Four Derm AF

Itching
Irritation
Thinning of skin
Skin irritation

How to use Four Derm AF Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Four Derm AF Cream works

Four Derm AF Cream is a combination of three medicines: Clobetasol, Neomycin and Miconazole which treat skin infections. Clobetasol is a steroid medicine. It blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen and itchy. Neomycin is an antibiotic which kills bacteria by preventing the synthesis of essential proteins required by bacteria to carry out vital functions. Miconazole is an antifungal which stops the growth of fungi by preventing them from forming their own protective covering.

Safety advice

Alcohol

No interaction found/established

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Four Derm AF Cream during pregnancy is not available. Please consult your doctor.

Breast feeding

CAUTION

Four Derm AF Cream should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

What if you forget to take Four Derm AF Cream?

If you miss a dose of Four Derm AF Cream, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Four Derm AF Cream

₹11.82/gm of Cream

Clobikem-Gm Neo Cream

Alkem Laboratories Ltd

₹6.91/gm of cream

42% cheaper

New O2 Derm Cream Lavender

Medley Pharmaceuticals

₹5.37/gm of cream

55% cheaper

Quick tips

Four Derm AF Cream must be applied as a thin layer on the affected area as prescribed by your doctor.
Do not use this medicine more often or for longer than advised by your doctor.
Before each application, wash the affected area with soap and water and dry well.
Avoid getting it in the eyes, mouth or nose. Rinse with cold water if you accidentally get it in these areas.
Do not cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
Inform your doctor if the treated skin area does not improve after 2-4 weeks of treatment.

Fact Box

Habit Forming

Therapeutic Class

DERMA

Patient concerns

I have got fungal infection on hips and pelvic area. applied four derm cream and other etrquinazole tablets but to no avail. what should I do

Dr. Souvik Sardar

Dermatology

For God's sake please stop using this bogus 3rd class creamsItraconazole won't even work if u continue fourdermWhy don't u visit a proper dermatologist (with degrees in skin and a self proclaimed Dermatologist with no degrees in skin specialisation !!!!!!!)If it has spread into many areas then just go and visit a dermatologist for a written prescription for oral antifungals. .Bcoz they need some investigations before starting the medicines

Got ithing ring on thighs joint, used four derm from cipla but no use Currentry im using candiforce 100mg

Dr. Souvik Sardar

Dermatology

Dnt expect 3rd class bogus creams like fourderm to do any good thing you have damaged your skin and worsened the problemwho prescribed you candiforce

I am suffering from a ringworm from last two months. I have used tocoderm, clop gm, four derm, dermikem and tablets candiforce, flusole etc. But there is no improvement please tell me what to do.

Dr. Souvik Sardar

Dermatology

U've already damaged ur skin by using all these bogus medicines I suggests u to visit a dermatologist for a face to face examination and investigations before starting oral medication

Can I stop taking Four Derm AF Cream when I feel better?

No, do not stop taking Four Derm AF Cream and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured.

What if I don't get better after using Four Derm AF Cream?

Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.

How long does Four Derm AF Cream takes to work?

Usually, Four Derm AF Cream starts working soon after applying it. However, it may take some days to kill all the harmful bacteria and make you feel better.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Clobetasol propionate. Uxbridge, Middlesex: GlaxoSmithKline UK; 1993 [revised 18 Oct. 2017]. [Accessed 04 Apr. 2019] (online) Available from:
ScienceDirect. Neomycin. [Accessed 31 Mar. 2019] (online) Available from:
Miconazole. Schorndorf, Germany: Catalent Germany Schorndorf; 1974 [revised Aug. 2018]. [Accessed 29 Mar. 2019] (online) Available from:
ScienceDirect. Chlorocresol. [Accessed 03 Apr. 2019] (online) Available from:
Clobetasol Propionate, Neomycin Sulphate, Miconazole Nitrate, Chlorocresol. Sirmour, H.P.: Algen Healthcare Ltd.; [Accessed 16 Feb. 2026] (online). Available from: