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Eprex 4000 Injection is a medicine that helps your bone marrow to produce more red blood cells. It is used to treat a type of anemia caused by kidney disease. It is also used to treat anemia caused by cancer chemotherapy and by medicines to treat HIV.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 19 Sep 2025 | 03:30 PM (IST)
₹1556 MRP ₹1706.259% off 
 
 
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Eprex 4000 Injection image
Eprex 4000 Injection image

Product introduction

Eprex 4000 Injection is given by injection either under the skin or into a vein, which will be decided by your doctor. Usually, the injections are given by a nurse or doctor. The dose depends on your body weight and the cause of your anemia. Iron supplements both before and during treatment may make this treatment more effective. Eprex 4000 Injection needs to be stored in a fridge but used at room temperature.


The most common side effects of taking this medicine include nausea, vomiting, fever, and increased blood pressure. It may also cause flu-like symptoms such as headache, tiredness, dizziness, and aches and pains. These side effects are most common at the start of treatment, but if they persist, your doctor may be able to suggest ways of preventing or reducing them. Tell your doctor straight away if you get any serious side effects, including seizures (fits). Sometimes, this medicine can cause serious blood clots that need urgent medical attention.


Before using Eprex 4000 Injection, you should tell your doctor if you have uncontrolled high blood pressure, heart disease, or gout (a disease of joint pain). You should also tell him/her what other medicines you are taking in case they affect this treatment. Your blood pressure should be checked often during this treatment by you or your doctor. You may also need other regular medical tests to be sure this medicine is not causing harmful effects. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

Benefits of Eprex Injection

Treatment of Anemia due to cancer chemotherapy
Anemia is a condition where your body does not have enough red blood cells to carry oxygen around your body. Eprex 4000 Injection is a man-made protein that works by stimulating the bone marrow (soft tissue inside the bones) to produce more red blood cells. The natural human form of this protein may be reduced when you are having chemotherapy to treat some types of cancer. An injection of the medicine can reduce the need to have a blood transfusion. You may also be given iron supplements to make the treatment more effective.
Treatment of Anemia due to chronic kidney disease
Eprex 4000 Injection is a man-made protein that helps your bone marrow to produce more red blood cells. It is used to treat anemia which is caused by kidney disease in adults and children who are on dialysis. Anemia is a condition where your body does not have enough red blood cells to carry oxygen around your body. This medicine helps reduce weakness and tiredness that you may be experiencing due to anemia. The injection is usually given by a doctor after a dialysis treatment.

Side effects of Eprex Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Eprex
  • Muscle spasm
  • Dizziness
  • Vascular occlusion
  • Injection site irritation
  • Stomatitis (Inflammation of the mouth)
  • Weight loss
  • Decreased white blood cell count (lymphocytes)
  • Increased glucose level in blood
  • Blood clot in the blood vessels
  • High blood pressure
  • Nausea
  • Vomiting
  • Fever
  • Rash
  • Joint pain
  • Headache
  • Insomnia (difficulty in sleeping)
  • Chills

How to use Eprex Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Eprex Injection works

Eprex 4000 Injection is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells.

All substitutes for Eprex 4000 Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Your doctor may get your blood tests done regularly to monitor the levels of hemoglobin, blood cells, and electrolytes such as potassium in your blood.
  • Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure, such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures).
  • Stop taking Eprex 4000 Injection and inform your doctor if you develop shortness of breath or a skin rash.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Eprex 4000 Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Eprex 4000 Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Eprex 4000 Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

UNSAFE
Eprex 4000 Injection may cause side effects which could affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Eprex 4000 Injection is safe to use in patients with kidney disease. No dose adjustment of Eprex 4000 Injection is recommended.
Regular monitoring of kidney function tests is advised while the patient is taking this medicine.
Liver

Liver

CAUTION
Eprex 4000 Injection should be used with caution in patients with liver disease. Dose adjustment of Eprex 4000 Injection may be needed. Please consult your doctor.

Frequently asked questions

Tell the doctor or nurse immediately if you think too much Eprex 4000 Injection has been injected.
Eprex 4000 Injection should not be used if the solution is cloudy, or if you can see particles floating in it, or if the medicine has expired. Refer to the expiry date on the label. You should also not use the medicine if you know or think that it may have been accidentally frozen or if there has been a refrigerator failure.
Yes, Eprex 4000 Injection is used to treat anemia caused due to chronic kidney disease in children who are above 1 year of age. The effectiveness of Eprex 4000 Injection and side effects seen in children are similar to adults.
Yes, Eprex 4000 Injection can affect blood pressure. During initial therapy with Eprex 4000 Injection, blood pressure should be monitored, and those who have high blood pressure should take appropriate measures to control blood pressure. Your doctor may stop Eprex 4000 Injection if the blood pressure remains uncontrolled.
In the hospital, pre-filled syringes are stored unopened in a refrigerator between 2 and 8℃. If you are using this medicine at home, the pre-filled syringe must be stored in your refrigerator. Do not store it in the freezer. Allow the pre-filled syringe to reach room temperature before using it. This usually takes between 15 and 30 minutes. Eprex 4000 Injection pre-filled syringes that are being used or about to be used can be kept at room temperature (not above 25°C) for a maximum single period of 7 days. Keep these pre-filled syringes away from children and protected from light.

Fact Box

Chemical Class

Amino Acids, Peptides Analogues

Habit Forming

No

Therapeutic Class

BLOOD RELATED

Action Class

Erythropoiesis-Stimulating Agents (ESAs)
100% genuine products
100% genuine products
Safe & secure payments
Safe & secure payments
No contact delivery
No contact delivery
Fully sanitized facilities
Fully sanitized facilities

User feedback

Once A Week
54%
Twice A Week
23%
Once A Month
11%
Once A Day
5%
Twice A Month
4%
Thrice A week
2%
Alternate Day
2%
Anemia due to chronic kidney disease
61%
Anemia
17%
Anemia due to cancer chemotherapy
11%
Others
11%
Excellent
52%
Poor
24%
Average
24%
No Side Effect
67%
Pulmonary thromboembolism (blood clot in the lungs)
33%
With food
40%
Empty stomach
40%
With or without food
20%
Expensive
83%
Average
17%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Janssen Pharmaceuticals
Address: Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060

Vendor Details

Country of origin: Switzerland
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