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18 Feb 2020 | 05:25 PM (IST)
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Epixtra 10mg Injection

Prescription Required

Overview

Introduction

Epixtra 10mg Injection is used in the treatment of various types of cancers of blood, breast, stomach, lung, ovaries and soft tissues. It also helps to prevent the recurrence of bladder cancer after surgery.

It is given as a drip or infusion vein with extreme caution by a qualified medical professional. It can be used alone, or sometimes given together with certain other medicines as part of combination chemotherapy. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes contraceptive pills less effective, so it advised to both male and female to use reliable contraception during the treatment.

The most common side effects of this medicine include nausea, low blood platelets, hair loss, absence of menstrual periods, fever and rash. It is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Infections can sometimes be life threatening. Regular blood tests are required to monitor your blood cells along with kidney, liver and heart function during treatment with this medicine.

Before taking this medicine, tell your doctor if you have liver disease, or have heart problem. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant or breastfeeding.

Uses of Epixtra Injection

Side effects of Epixtra Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Epixtra

  • Low blood platelets
  • Nausea
  • Hair loss
  • Absence of menstrual periods
  • Fever
  • Anemia (low number of red blood cells)
  • Diarrhea
  • Weight loss
  • Decreased white blood cell count (neutrophils)
  • Hot flashes
  • Gastrointestinal inflammation
  • Rash
  • Low energy
  • Eye disorder

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Low blood platelets
    You will need a blood test to find out if your blood platelet level is low. If this medicine is causing your platelet levels to drop, your doctor may suggest an alternative medicine. There are also medicines that can boost your blood platelet level. Consider asking your doctor about this. A low platelet count can put you at risk for bleeding. Try to be careful when doing activities that might cause an injury or a cut as it may take longer to stop bleeding.
  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Hair loss
    Use gentle hair products such as baby shampoo. Use a soft brush and comb gently. Avoid using hairdryers, curling tongs or hair straighteners and pat your hair dry after washing. Do not color your hair. Protect your scalp by covering your head in the sun. It is necessary to not take the stress and eat a balanced, nutritious diet as it is vital for the health of your hair.
  • Coping with Anemia (low number of red blood cells)
    Making some simple lifestyle changes can raise your red blood cell count. Reduce the amount of alcohol you drink, eat a well-balanced healthy diet and take regular exercise. Physical activities make your body need more oxygen and this stimulates the production of red blood cells. There are some vitamins which are important such as vitamin B-12, vitamin B-9, vitamin C and Vitamin A. Also, some minerals such as iron (especially) and copper. Aim for foods which contain higher quantities of these vitamins and minerals or ask your doctor for supplements. Make sure to consult your doctor for complete evaluation and treatment of anemia.
  • Coping with Diarrhea
    Keep up your intake of fluids and electrolytes (sugars and salts) to avoid getting dehydrated. Eat less fiber (avoid raw fruits, fruit juice and vegetables). Talk to your doctor about possible medication to manage diarrhea. Ask about reducing the dosage of your drug or other suitable treatments.
  • Coping with Weight loss
    As a general rule, speak to your doctor if you lose weight while using this medicine. Losing too much weight can lead to malnutrition. Increase the amount of food you eat. Try eating foods that are high in calories and protein. Drink warm milk instead of tea every so often. Eat smaller meals and eat more often. There may be medicines and physical activities that can improve your condition.Speak to your doctor about this.
  • Coping with Decreased white blood cell count (neutrophils)
    If you have a low level of white blood cells, you are more likely to get infections. There are several ways to reduce your chances of catching or spreading an infection. Avoid unnecessary exposure to germs when you can. Wash your hands frequently and thoroughly with soap or use a sanitiser. Avoid crowds and avoid contact with people who are ill or have infections. Use disposable tissues for coughs and sneezes. Consider using an appropriate face mask. Do not share personal items like cutlery, glasses, towels or toothbrushes with others. Get enough rest and eat a well balanced healthy diet.
  • Coping with Hot flashes
    Sip cold or iced drinks. Try cutting down on coffee, tea and alcohol. It might help to keep the room cool and use a fan. You could also spray cool water on your face. Wear layers of light clothing that you can easily take off if you overheat. Breathe deeply and try to relax. Have a lukewarm shower or bath instead of a hot one. Avoid smoking and cut down on alcohol. The flushing should go away after a few days. If it does not go away or causes problems, contact your doctor. There may be medicines that can help.
  • Coping with Rash
    There are many treatments for a wide range of skin problems. Avoid hot showers or baths because hot water can irritate the skin. Make sure to pat dry your skin after a bath or shower. Do not rub or scratch the affected area. Leave the skin exposed to the air as much as possible. Do not use perfumed soaps or deodorants. Water containing chlorine can make most skin problems worse, so avoid swimming. Avoid spicy foods, alcohol, tobacco smoke and caffeine as it may also make itching worse. Avoid excessive sun exposure. Always use sunscreen and protective clothing when outdoors. Moisturizers can be used regularly to soothe and hydrate the affected area. If it does not get better within a week, speak to a pharmacist or doctor.

How to use Epixtra Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Epixtra Injection works

Epixtra 10mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the breast cancer cells. It also forms harmful chemicals (free radicals) which cause DNA damage. This slows the growth of breast cancer cells and eventually kills them.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Epixtra 10mg Injection.
Pregnancy
CONSULT YOUR DOCTOR
Epixtra 10mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
UNSAFE
Epixtra 10mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Epixtra 10mg Injection may cause side effects which could affect your ability to drive.
Epixtra 10mg Injection may cause episodes of nausea and vomiting, which can temporarily lead to an impairment of the ability to drive.
Kidney
SAFE IF PRESCRIBED
Epixtra 10mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Epixtra 10mg Injection may not be needed in these patients. Please consult your doctor.
Lower doses may be considered in patients with serum creatinine > 5 mg/dL.
Liver
CAUTION
Epixtra 10mg Injection should be used with caution in patients with liver disease. Dose adjustment of Epixtra 10mg Injection may be needed. Please consult your doctor.
Use of Epixtra 10mg Injection is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Epixtra 10mg Injection
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Quick Tips

  • Epixtra 10mg Injection is used alone or in combination with other medicines for the treatment of various types of cancers.
  • It is given through a drip into a vein (intravenous infusion) by a doctor or nurse.
  • It may make you feel tired or sleepy.  Do not drive or do anything that requires mental focus until you know how it affects you.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for 6 months after stopping treatment.
  • Your doctor may get regular blood tests done to monitor your blood cells, liver, and heart function during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.

Patient Concerns

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Bee sting below middle finger, on palm yesterday. Swelling and redness today after approx 20 hours. No pain, only itching.
Dr. Souvik Sardar
Dermatology
Visit emergency for an injection at that place Instant reliefTake tab teczine 10mg -1tab at bedtime for itching
After giving hucog injection and duphaston 10mg I will get pragancy or not
Dr. Pranay Gandhi
Sexology
if ur husbands semen is normal and u just face an ovulation problem, u will get pregnant. u must know that even for normal couple chances of getting pregnant after sex once is just 8%
arrow
Do you have any questions related to Epixtra 10mg Injection ?

FAQs

Q. Is Epixtra a vesicant (agent that causes tissue blistering and damage)?

Yes, Epixtra is a vesicant; it may cause tissue blistering if it leaks out of the vein

Q. Is Epixtra an anthracycline?

Yes, Epixtra belongs to anthracycline class of anti-cancer medicines

Q. Is Epixtra a doxorubicin?

Epixtra and doxorubicin are both anticancer agents that belong to the anthracycline group

Q. Is Epixtra an antibiotic?

Epixtra is an anticancer antibiotic

Q. What is Epixtra used for?

Epixtra is used in the treatment of various cancers including cancer of the breast, ovary, stomach, lung, bowel or rectum, malignant lymphomas (a type of blood cancer of infection-fighting cells of the blood) such as Hodgkin's disease and non-Hodgkin's lymphoma, leukemia (blood cancer), multiple myeloma (a type of blood cancer of infection-fighting cells of the blood). It may be used in bladder cancers and to prevent reoccurrence of bladder cancer after surgery

Q. What is Epixtra made from?

Epixtra is made from natural products produced by species of soil fungus Streptomyces

Q. How is Epixtra given?

Epixtra is given by injection into the vein or through a catheter into the bladder

Q. How effective is Epixtra?

Epixtra is effective in the treatment of various cancers including cancer of the breast, ovary, stomach, lung, bowel or rectum, malignant lymphomas (a type of blood cancer of infection-fighting cells of the blood) such as Hodgkin's disease and non-Hodgkin's lymphoma, leukemia (blood cancer), multiple myeloma (a type of blood cancer of infection-fighting cells of the blood). It may be used in bladder cancers and to prevent reoccurrence of bladder cancer after surgery. It effectively slows or stops the growth of cancer cells in the body

Q. How much does Epixtra cost?

The price of Epixtra may vary depending upon the brand prescribed to you. Please read the instruction on the package for the correct price of the product.

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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1715.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 952.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 478-79.
  4. Epirubicin hydrochloride. Wedel, Germany: Medac GmbH; 2008 [revised Jun. 2016]. [Accessed 26 Mar. 2019] (online) Available from:External Link
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
A licensed vendor partner from your nearest location will deliver Epixtra 10mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
MRP448.32  Get 15% OFF
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₹381.07
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