Direz 25mg/50mg Tablet
Prescription RequiredProduct introduction
Direz 25mg/50mg Tablet is a combination of two medicines used to treat hypertension (high blood pressure). It reduces excess fluid levels in your body and maintains the potassium balance in the body. This medicine makes you lose excess water through urine.
It is best to take Direz 25mg/50mg Tablet in the morning along with food in order to avoid frequent urination at night time. For better results, it is suggested to take it at the same time every day. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.
Headache, glucose intolerance, and dryness of mouth are very common side effect of this medicine. It might lower down the electrolytes level like sodium, potassium, and magnesium in the blood. Hence, regular monitoring of kidney function and electrolytes is important while using this medicine. It might cause dizziness or tiredness if happens rise slowly from sitting position or avoid driving.
Before taking this medicine, tell your doctor if you have any liver or kidney disease. Inform your doctor if you are pregnant or breastfeeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.
Uses of Direz Tablet
Benefits of Direz Tablet
In Hypertension (high blood pressure)
Direz 25mg/50mg Tablet relaxes the blood vessels so that blood can flow more easily around your body. It also eliminates excess water from the body and increases urine output. This maintains balance of electrolytes (like potassium), lowers your blood pressure and reduces your risk of having a stroke, a heart attack, or kidney problems in the future. You do not usually feel any direct benefit from taking this medicine, but it works in the long term to keep you well. You should take it regularly as prescribed for this medicine to be most effective, even if you feel better.
Side effects of Direz Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Direz
- Headache
- Glucose intolerance
- Dryness in mouth
- Feeling thirsty
- Increased production of urine
- Increased blood lipid level
- Electrolyte imbalance
- Increased uric acid level in blood
- Kidney stone
How to use Direz Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Direz 25mg/50mg Tablet should be taken with or after food.
How Direz Tablet works
Direz 25mg/50mg Tablet is a combination of two diuretics: Benzthiazide and Triamterene.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Direz 25mg/50mg Tablet
Pregnancy
CONSULT YOUR DOCTOR
The safety of Direz 25mg/50mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding
CONSULT YOUR DOCTOR
Direz 25mg/50mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether Direz 25mg/50mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney
CAUTION
Direz 25mg/50mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Direz 25mg/50mg Tablet is not recommended in patients with severe kidney disease. Regular monitoring of kidney function test and potassium levels may be advised while you are taking this medicine.
Use of Direz 25mg/50mg Tablet is not recommended in patients with severe kidney disease. Regular monitoring of kidney function test and potassium levels may be advised while you are taking this medicine.
Liver
CAUTION
Direz 25mg/50mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Direz 25mg/50mg Tablet is not recommended in patients with severe liver disease.
Use of Direz 25mg/50mg Tablet is not recommended in patients with severe liver disease.
What if you forget to take Direz Tablet?
If you miss a dose of Direz 25mg/50mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Direz 25mg/50mg Tablet is prescribed to reduce high blood pressure.
- It helps you to lose water. If, however, you lose too much fluid, you may become dehydrated. This will make you feel thirsty and make your skin look and feel dry. Let your doctor know if this happens, as your dose may need to be adjusted.
- Your doctor may get regular test done to monitor the level of urea, creatinine, and potassium in your blood.
- It is better to take Direz 25mg/50mg Tablet during the day. This is because you will find you may need to go to the toilet a couple of times after taking it and this will disturb your sleep if you take it at night.
- Monitor your blood pressure regularly after starting treatment with Direz 25mg/50mg Tablet, and notify your doctor if it does not lower down.
Fact Box
Habit Forming
No
Therapeutic Class
CARDIAC
Patient concerns
FAQs
Can the use of Direz 25mg/50mg Tablet cause dizziness?
Yes, the use of Direz 25mg/50mg Tablet can make you feel dizzy. This may often occur when you suddenly rise up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
What are the instructions for the storage and disposal of Direz 25mg/50mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Yajnik VH, Doshi HV, Patel SC, et al. Combined treatment with triamterene and benzthiazide in cases of hypertension. J Assoc Physicians India. 1977 Jan;25(1):31-6. [Accessed 13 Jan. 2026]. Available from:
Marketer details
Name: Biochem Pharmaceutical Industries
Address: BIOCHEM PHARMA, LG 113 / A, Xth Central Mall, Mahavir Nagar, 90ft Road, Next to D Mart, Kandivali - West, Mumbai - 400067.
Country of origin: India
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