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Demac-MR Tablet is a combination medicine used in the treatment of pain due to muscle spasms. It improves the movement of muscles and provides relief from pain and discomfort associated with muscle spasms.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 22 Sep 2025 | 01:35 AM (IST)
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Demac-MR Tablet
Demac-MR Tablet
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₹4.0 per tablet
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₹1200
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by Makmaul Labocare
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Zeldinac-MR Tablet
Zeldinac-MR Tablet
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₹3.18 per tablet
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₹31.8

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₹1200
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by Leeford Healthcare Ltd

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General Information

Contains

Chlorzoxazone (250mg)+ Diclofenac (50mg)+ Paracetamol (325mg)

Marketer

Makmaul Labocare

Storage

Store below 30°C
The content is shown in English
Demac-MR Tablet image
Demac-MR Tablet image
Demac-MR Tablet image

Product introduction

Demac-MR Tablet can be taken with or without food. Take it in the dose and duration advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.


Common side effects of Demac-MR Tablet include nausea, dizziness, and stomach pain. If any of these side effects bother you or do not go away with time, you should let your doctor know. Your doctor may help with ways to reduce or prevent these side effects.


The medicine may not be suitable for everybody. Before taking it, let your doctor know if you have any problems with your heart, kidneys, or liver. To make sure it is safe for you, let your doctor also know about all the other medicines you are taking. Pregnant and breastfeeding mothers should first consult their doctors before using the medicine.

Uses of Demac-MR Tablet

  • Treatment of Pain due to muscle spasm

Benefits of Demac-MR Tablet

Treatment of Pain due to muscle spasm
Demac-MR Tablet is a combination medicine that is used to relieve pain, inflammation, and swelling in conditions that affect muscles. Also, it effectively relieves muscle stiffness or spasm, thereby improving muscle movement. It works by blocking chemical messengers in the brain that tell us we have pain.

Take it as it is prescribed to get the most benefit. Do not take more or longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Demac-MR Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Demac-MR
  • Dizziness
  • Constipation
  • Abdominal pain
  • Indigestion
  • Nausea

How to use Demac-MR Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Demac-MR Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Demac-MR Tablet works

Demac-MR Tablet is a combination of a muscle relaxant (Chlorzoxazone) and two pain-relieving medicines (Diclofenac and Paracetamol). The muscle relaxant works on the centers in the brain and spinal cord to relieve muscle stiffness or spasms, thereby improving the movement of muscles. The pain-relieving medicines work by blocking the release of certain chemical messengers in the brain that cause pain and inflammation (redness and swelling).

All substitutes for Demac-MR Tablet

For information purposes only. Consult a doctor before taking any medicine.

Zeldinac-MR Tablet

by Leeford Healthcare Ltd
₹3.74/tablet
21% cheaper
<h3 class=bodySemiBold>Zeldinac-MR Tablet</h3>

Intagesic-MR Tablet

by Intas Pharmaceuticals Ltd
₹7.13/tablet
51% costlier
<h3 class=bodySemiBold>Intagesic-MR Tablet</h3>

Powerflam MR Tablet

by Alkem Laboratories Ltd
₹6.61/tablet
40% costlier
<h3 class=bodySemiBold>Powerflam MR Tablet</h3>

Powergesic Tablet

by Jenburkt Pharmaceuticals Ltd
₹15.3/tablet
225% costlier
<h3 class=bodySemiBold>Powergesic Tablet</h3>

Lobak Tablet

by Geno Pharmaceuticals Ltd
₹8.31/tablet
76% costlier
<h3 class=bodySemiBold>Lobak Tablet</h3>

Quick tips

  • Demac-MR Tablet is most effective when taken along with proper rest and physical therapy.
  • Avoid consuming alcohol when taking Demac-MR Tablet, as it may cause excessive drowsiness and increase the risk of liver damage.
  • Older adults may have increased drowsiness, confusion, and a higher risk of falling as a result of taking Demac-MR Tablet.
  • Do not take it with any other medicine containing acetaminophen (drugs for pain/fever or cough and cold) without asking your doctor first.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Demac-MR Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Demac-MR Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Demac-MR Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

UNSAFE
Demac-MR Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

UNSAFE
Demac-MR Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
Liver

Liver

CAUTION
Demac-MR Tablet should be used with caution in patients with liver disease. Dose adjustment of Demac-MR Tablet may be needed. Please consult your doctor.

Frequently asked questions

Demac-MR Tablet is a combination of three medicines: diclofenac, paracetamol, and chlorzoxazone. This medication helps relieve muscle pain. Chlorzoxazone is a muscle relaxant that works by acting on the central nervous system. Diclofenac and paracetamol work by lowering the chemical substance (prostaglandins) in the body that causes pain and inflammation.
Demac-MR Tablet should be continued if advised for a specific time duration by your doctor. However, it can be discontinued if you are using it for short-term pain relief.
Yes, the use of Demac-MR Tablet can cause nausea and vomiting. In case you experience nausea while taking this medicine, take it with milk, food, or antacids. Avoid taking fatty or fried foods along with this medication. In case of vomiting, drink plenty of water or other fluids by taking small, frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark-colored, strong-smelling, and infrequent urination. Do not take any other medicine without speaking to your doctor.
Yes, the use of Demac-MR Tablet can cause dizziness (feeling faint, weak, unsteady, or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for some time and resume once you feel better.
Yes, the long-term use of Demac-MR Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protects them from damage. The use of painkillers lowers the levels of prostaglandins in the body, leading to kidney damage on long-term use. The use of painkillers is not recommended for patients with underlying kidney disease.
No, taking a higher dose than the recommended dose of Demac-MR Tablet can increase the risks of side effects. If you are experiencing increased severity of pain or if the pain is not relieved by the recommended doses, please consult your doctor for reevaluation.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

References

  1. Diclofenac [Prescribing Information]. Rouse Boulevard, Philadelphia: Iroko Pharmaceuticals; 1998 [revised Oct. 2013]. [Accessed 02 Apr. 2019] (online) Available from:
  2. Diclofenac [EMC Label]. Daventry, Northamptonshire: Dexcel Pharma Ltd.; 2017]. [Accessed 02 Apr. 2019] (online) Available from:
  3. ScienceDirect. Paracetamol. [Accessed 02 Apr. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Makmaul Labocare
Address: BT/105 PHASE 1 M.P.I.A DELHI-83 AO-11133 PRESTIGE SHANTIKETAN WHITEFIELD BANGALORE -560048 (INDIA)

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Demac-MR Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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