COM D3N Plus Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 25 Nov 2025 | 03:07 PM (IST)

COM D3N Plus Tablet is a combination medicine used for the treatment of neuropathic pain. This medicine decreases pain by controlling the calcium channel activity of the nerve cells and increases the level of chemical messengers in the brain that help regulate mood and protect nerve fibers.

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General Information

Contains

Pregabalin (75mg)+ Nortriptyline (10mg)+ Methylcobalamin (1500mcg)+ Vitamin D3 (2000IU)

Marketer

Comed Chemicals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

COM D3N Plus Tablet can be taken with or without food. However, it is advised to take it at the same time each day, as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by the doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine without talking to the doctor, as it may worsen your symptoms.

Some common side effects of this medicine include headache, nausea, and diarrhea. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain, and to control it, you should have a balanced diet and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.

Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Uses of COM D3N Tablet

Neuropathic pain

Benefits of COM D3N Tablet

Neuropathic pain
COM D3N Plus Tablet helps relieve nerve pain (neuropathic pain) by calming overactive nerves (pregabalin), improving mood and pain relief (nortriptyline), repairing nerve damage (methylcobalamin), and supporting nerve and bone health (vitamin D3). It reduces burning, tingling, and stabbing pain, improving comfort and quality of life.

Side effects of COM D3N Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of COM D3N

Constipation
Sleepiness
Dizziness
Tiredness
Blurred vision
Dryness in mouth

How to use COM D3N Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. COM D3N Plus Tablet may be taken with or without food.

How COM D3N Tablet works

COM D3N Plus Tablet combines four medicines: pregabalin, nortriptyline, methylcobalamin, and vitamin D3. Pregabalin is an alpha-2 delta ligand that decreases pain by modulating the calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant that increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Methylcobalamin is a form of vitamin B that helps produce myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Vitamin D3 helps nerves send messages properly in the body. It supports brain chemicals, protects nerve coverings, and reduces swelling, which keeps nerves healthy and helps relieve pain. Together, they relieve neuropathic pain (pain from damaged nerves).

Quick tips

COM D3N Plus Tablet is used to treat certain types of long-lasting pain caused by damage to nerves.
Inform your doctor if you are taking any other pain-relieving medicines.
Inform your doctor if you have a history of seizures.
Immediately seek medical help if you experience hallucinations, fever, sweating, shivering, a fast heart rate, muscle twitching, or loss of coordination.
Along with taking COM D3N Plus Tablet, your doctor might advise you to undergo physiotherapy to get relief from pain.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. COM D3N Plus Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of COM D3N Plus Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

COM D3N Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

COM D3N Plus Tablet may cause side effects that could affect your ability to drive.
As COM D3N Plus Tablet may affect your alertness which may affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

COM D3N Plus Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

SAFE IF PRESCRIBED

COM D3N Plus Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Frequently asked questions

How quickly does COM D3N Plus Tablet work?

The exact time COM D3N Plus Tablet takes to work is not known. However, you may expect improvement in pain relief in a few weeks of regular use. The full benefit may take longer and it depends on the condition and its severity.

What to do if I experience a rash over my body?

Experiencing rash over the body may be a sign of an adverse reaction due to COM D3N Plus Tablet. You should stop taking COM D3N Plus Tablet and report it to your prescribing doctor at the earliest.

Does COM D3N Plus Tablet cause dizziness?

Dizziness or drowsiness is a side effect of COM D3N Plus Tablet. If you feel dizzy or drowsy after taking COM D3N Plus Tablet, avoid indulging in activities requiring alertness. If these symptoms become severe, consult your prescribing doctor.

How long does COM D3N Plus Tablet take to work?

You may start feeling relief within a few days, but it can take a few weeks for full benefits. Take it regularly as prescribed by your doctor.

Can I stop taking COM D3N Plus Tablet suddenly?

No, stopping COM D3N Plus Tablet suddenly may cause withdrawal symptoms or worsen your condition. Always consult your doctor before stopping or changing the dose.

Who should not take COM D3N Plus Tablet?

Individuals should not take COM D3N Plus Tablet if they are allergic to pregabalin, nortriptyline, methylcobalamin, vitamin D3, and other ingredients present in the COM D3N Plus Tablet formulation. This is particularly if they have/had issues with the heart and/or are recovering from a heart attack.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Comed Chemicals Ltd
Address: 2nd Floor, Sun Plaza-I, Nr. Vadsar Bridge, GIDC Road, Makarpura, Vadodara - 390 010.

Vendor Details

Country of origin: India

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Why we need a prescription?

COM D3N Plus Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of COM D3N Tablet

Benefits of COM D3N Tablet

Side effects of COM D3N Tablet

How to use COM D3N Tablet

How COM D3N Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

How quickly does COM D3N Plus Tablet work?

What to do if I experience a rash over my body?

Does COM D3N Plus Tablet cause dizziness?

How long does COM D3N Plus Tablet take to work?

Can I stop taking COM D3N Plus Tablet suddenly?

Who should not take COM D3N Plus Tablet?

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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