COM D3N Plus Tablet is a combination medicine used for the treatment of neuropathic pain. This medicine decreases pain by controlling the calcium channel activity of the nerve cells and increases the level of chemical messengers in the brain that help regulate mood and protect nerve fibers.

COM D3N Plus Tablet can be taken with or without food. However, it is advised to take it at the same time each day, as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by the doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine without talking to the doctor, as it may worsen your symptoms.

Some common side effects of this medicine include headache, nausea, and diarrhea. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain, and to control it, you should have a balanced diet and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.

Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Uses of COM D3N Tablet

Treatment of Neuropathic pain

Benefits of COM D3N Tablet

In Treatment of Neuropathic pain

COM D3N Plus Tablet helps relieve nerve pain (neuropathic pain) by calming overactive nerves (pregabalin), improving mood and pain relief (nortriptyline), repairing nerve damage (methylcobalamin), and supporting nerve and bone health (vitamin D3). It reduces burning, tingling, and stabbing pain, improving comfort and quality of life.

Side effects of COM D3N Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of COM D3N

Constipation
Sleepiness
Dizziness
Tiredness
Blurred vision
Dryness in mouth

How to use COM D3N Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. COM D3N Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.

How COM D3N Tablet works

COM D3N Plus Tablet combines four medicines: pregabalin, nortriptyline, methylcobalamin, and vitamin D3. Pregabalin is an alpha-2 delta ligand that decreases pain by modulating the calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant that increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Methylcobalamin is a form of vitamin B that helps produce myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Vitamin D3 helps nerves send messages properly in the body. It supports brain chemicals, protects nerve coverings, and reduces swelling, which keeps nerves healthy and helps relieve pain. Together, they relieve neuropathic pain (pain from damaged nerves).

Safety advice

Alcohol

UNSAFE

COM D3N Plus Tablet may cause excessive drowsiness with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

COM D3N Plus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

COM D3N Plus Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

COM D3N Plus Tablet may cause side effects which could affect your ability to drive.
As COM D3N Plus Tablet may affect your alertness which may affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

COM D3N Plus Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of COM D3N Plus Tablet may not be needed in these patients. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

COM D3N Plus Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of COM D3N Plus Tablet may not be needed in these patients. Please consult your doctor.

What if you forget to take COM D3N Tablet?

If you miss a dose of COM D3N Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

COM D3N Plus Tablet

₹24.64/Tablet

Neurotrat NP Tablet

Zydus Cadila

₹26.8/tablet

9% costlier

Nervestin Gold Tablet

Westin Pharmaceuticals Pvt. Ltd

₹20.6/tablet

16% cheaper

Com-D3 N Tablet

Comed Chemicals Ltd

₹19.8/tablet

20% cheaper

NP-Free Tablet SR

Symbion Lifescience

₹27.8/tablet

13% costlier

Indogaba NT Tablet

Novocin Pharmaceuticals

₹18.9/tablet

23% cheaper

View all substitutes

Quick tips

COM D3N Plus Tablet is used to treat certain types of long-lasting pain caused by damage to nerves.
Inform your doctor if you are taking any other pain-relieving medicines.
Inform your doctor if you have a history of seizures.
Immediately seek medical help if you experience hallucinations, fever, sweating, shivering, a fast heart rate, muscle twitching, or loss of coordination.
Along with taking COM D3N Plus Tablet, your doctor might advise you to undergo physiotherapy to get relief from pain.

Fact Box

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What is COM D3N Plus Tablet used for?

COM D3N Plus Tablet is used to relieve nerve pain (neuropathic pain) caused by nerve damage. It helps reduce burning, tingling, and stabbing pain.

Can I take COM D3N Plus Tablet during pregnancy?

COM D3N Plus Tablet should only be taken during pregnancy if prescribed by a doctor, as some ingredients may affect the baby. Always consult your doctor before use.

Does COM D3N Plus Tablet cause drowsiness?

Yes, COM D3N Plus Tablet may cause drowsiness or dizziness. Avoid driving or using heavy machinery until you know how it affects you.

How long does COM D3N Plus Tablet take to work?

You may start feeling relief within a few days, but it can take a few weeks for full benefits. Take it regularly as prescribed by your doctor.

Can I stop taking COM D3N Plus Tablet suddenly?

No, stopping suddenly may cause withdrawal symptoms or worsen your condition. Always consult your doctor before stopping or changing the dose.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Pregabalin [Prescribing Information]. Vega Baja, Puerto Rico: Pfizer Pharmaceuticals LLC; 2009. [Accessed 24 Apr. 2019] (online) Available from:
Methylcobalamin + Pregabalin + Nortriptyline [Product Information]. Gultekdi, Pune: Epione Pharma Pvt Ltd. [Accessed 06 Mar. 2025] (online) Available from: