Colobest-CL Tablet is used to treat irritable bowel syndrome (symptoms include abdominal pain, cramping, bloating, and diarrhea or constipation). It prevents the sudden spasm of muscles to relieve stomach pain and cramps. It also promotes easy passage of gas to reduce stomach discomfort.
Colobest-CL Tablet is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.
There is limited data on the side effects of Colobest-CL Tablet. Let your doctor know if you experience any symptoms while taking the medicine. They can suggest ways to treat or manage the side effects.
Before you start Colobest-CL Tablet, let your doctor know if you have any medical conditions. Let your doctor also know about all the medications you are taking, as some medicines may interact with Colobest-CL Tablet. Pregnant or breastfeeding women should consult their doctor before taking Colobest-CL Tablet to ensure safety.
Irritable Bowel Syndrome (IBS) is a chronic condition that causes abdominal pain, bloating, gas, and irregular bowel movements. Colobest-CL Tablet offers dual relief: It relaxes the intestinal muscles to ease cramps, discomfort, and helps reduce anxiety, which often worsens IBS symptoms. This medicine improves digestive comfort and helps restore regular bowel habits, making daily life more manageable.
Side effects of Colobest-CL Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Colobest-CL
Limited data available
How to use Colobest-CL Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Colobest-CL Tablet may be taken with or without food.
How Colobest-CL Tablet works
Colobest-CL Tablet is a combination of two medicines: Mebeverine and Chlordiazepoxide.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Colobest-CL Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Colobest-CL Tablet during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Colobest-CL Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether Colobest-CL Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor. As Colobest-CL Tablet may make you feel drowsy or affect your concentration and this may affect your ability to drive.
Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of Colobest-CL Tablet in patients with kidney disease. Please consult your doctor. Caution is advised in patients with severe kidney disease.
Liver
CONSULT YOUR DOCTOR
There is limited data available on the use of Colobest-CL Tablet in patients with liver disease. Caution is advised in patients with severe liver disease.
What if you forget to take Colobest-CL Tablet?
If you miss a dose of Colobest-CL Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
You have been prescribed Colobest-CL Tablet for the treatment of pain and other discomfort associated with irritable bowel syndrome.
Do not take Colobest-CL Tablet at least 2 hours before or after taking other medicines as it may interact with other medicines.
Inform your doctor if you have an enlarged prostate gland, glaucoma, or trouble passing urine.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Fact Box
Habit Forming
Yes
Therapeutic Class
GASTRO INTESTINAL
Patient concerns
Restless leg syndrome with irritable bowel syndrome
Dr. Pushkar Mani
Physician
take cobadex czs once daily for 1 monthevion 400 mg once daily for 1 month
Patient needs to take medication for duration which varies from one patent to other and there are different medications available. I would suggest that you visit the clinic
Yes, Colobest-CL Tablet may cause withdrawal symptoms. Do not stop taking Colobest-CL Tablet all of a sudden. Stopping Colobest-CL Tablet suddenly can cause seizures, shaking, stomach and muscle cramps, vomiting and sweating. Consult with your doctor before stopping Colobest-CL Tablet.
Can I drink alcohol while taking Colobest-CL Tablet?
No, avoid drinking alcohol while you are taking Colobest-CL Tablet. Drinking alcohol can increase the risk of side effects like drowsiness or sleepiness.
Can the use of Colobest-CL Tablet cause sleepiness or drowsiness?
Yes, Colobest-CL Tablet may make you feel drowsy or sleepy. Avoid driving, operating any machines, working at heights or participating in potentially dangerous activities at the start of your treatment. Inform your doctor if you experience such episodes while taking this medicine.
What precautions do I need to take while using Colobest-CL Tablet?
Colobest-CL Tablet should not be taken along with opioid-like substances as it contains chlordiazepoxide. Use of opioids along with chlordiazepoxide may cause excessive sedation (state of calm or sleep), respiratory depression and eventually coma or death. Inform your doctor about all the medicines that you are taking if you are advised to take Colobest-CL Tablet.
What are the symptoms of overdose of Colobest-CL Tablet?
Both Mebeverine and Chlordiazepoxide show different symptoms of overdose. Chlordiazepoxide can cause sleepiness, reflexes, confusion and coma. Whereas, Mebeverine can cause CNS excitability which is mild and reversible. Inform the doctor in case you take a higher dose and any of these symptoms appear.
Can the use of Colobest-CL Tablet cause constipation?
Yes, the use of Colobest-CL Tablet can cause constipation. Eat high-fiber foods like vegetables, fruits and cereals, and drink plenty of water. Exercise regularly by engaging in activities like swimming, jogging or taking a walk. Consult a doctor if the constipation persists for a long duration.
What are the instructions for storage and disposal of Colobest-CL Tablet?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
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References
Daniluk J, Malecka-Wojciesko E, Skrzydlo-Radomanska B, et al. The Efficacy of Mebeverine in the Treatment of Irritable Bowel Syndrome-A Systematic Review. J Clin Med. 2022;11(4):1044. [Accessed 22 Nov. 2025]. Available from: