Closis Plus Tablet is a combination of two medicines: Clonazepam and Propranolol. Clonazepam is a benzodiazepine. It works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in brain. Propranolol is a beta blocker which blocks the action of certain chemical messengers on the heart and blood vessels. This reduces heart rate, blood pressure, and strain on the heart.
Taking Propranolol with alcohol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.
WEIGH RISKS VS BENEFITS
Closis Plus Tablet is unsafe to use during pregnancy. There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Closis Plus Tablet is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby.
Closis Plus Tablet may cause side effects which could affect your ability to drive.
Closis Plus Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Closis Plus Tablet may not be needed in these patients. Please consult your doctor. Use of Closis Plus Tablet can cause excessive sleepiness in patients with end stage kidney disease.
Closis Plus Tablet should be used with caution in patients with liver disease. Dose adjustment of Closis Plus Tablet may be needed. Please consult your doctor. Regular monitoring of blood pressure is advisable for dose adjustment.