Closis Plus Tablet


Uses of Closis Plus Tablet
Closis Plus Tablet is used in the treatment of anxiety disorder.
Closis Plus Tablet side effects
  • Confusion
  • Memory impairment
  • Drowsiness
  • Slow heart rate
  • Tiredness
  • Uncoordinated body movements
  • Nightmare
  • Cold extremities
How to use Closis Plus Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Closis Plus Tablet is to be taken empty stomach.
How Closis Plus Tablet works
Closis Plus Tablet is a combination of two medicines: Clonazepam and Propranolol. Clonazepam is a benzodiazepine. It works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in brain. Propranolol is a beta blocker which blocks the action of certain chemical messengers on the heart and blood vessels. This reduces heart rate, blood pressure, and strain on the heart.
Closis Plus Tablet related warnings
Taking Propranolol with alcohol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.
Closis Plus Tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Closis Plus Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Closis Plus Tablet may cause side effects which could affect your ability to drive.
Closis Plus Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Closis Plus Tablet may not be needed in these patients. Please consult your doctor.
Use of Closis Plus Tablet can cause excessive sleepiness in patients with end stage kidney disease.
Closis Plus Tablet should be used with caution in patients with liver disease. Dose adjustment of Closis Plus Tablet may be needed. Please consult your doctor.
Regular monitoring of blood pressure is advisable for dose adjustment.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Patient Concerns

Questions Related to Closis Plus

Sir, my doctor had prescribed me pexti cr 12 .5 for my anxiety disorder. I had taken this medicine for 4 months and now my stopped this medication. After stopping it i feel moderately nauseated. My question is how long it will take to feel normal again?
Dr. Pushkar Mani
Diabetes Specialist
another month, take Ondem 4mg once daily in mornig
I m suffering from anxiety ,, prescribed me setarline 100 mg ( daxid) how long I can take this medicine ,, can I use it's low cost substitute ,, plz suggest
Dr. Jyoti Kapoor Madan
Maintenance phase after first episode of anxiety disorder lasts for 6 months,medicines are then gradually tapered off. Other substitutes are available but if you are better with it, it's better to continue because other antidepressant may or may not work adequately.
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Q. Can I stop taking Closis Plus if I feel well?
No, you should continue to take Closis Plus even if you feel well. If you stop Closis Plus suddenly, serious withdrawal problems may occur. Your doctor will decrease your dose gradually before asking you to stop Closis Plus. No, you should continue to take Closis Plus even if you feel well. If you stop Closis Plus suddenly, serious withdrawal problems may occur. Your doctor will decrease your dose gradually before asking you to stop Closis Plus.
Q. What are the instructions for the storage and disposal of Closis Plus?
Keep this medicine in the packet or container it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.
Q. Can I feel dizzy after taking Closis Plus?
Yes, the use of Closis Plus can make you feel dizzy. This may occur when you suddenly get up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 8th Mar 2017.
The medicine details are for information purpose only. Consult a doctor before taking any medicine.
Manufacturer/Marketer Address
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