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Amfosted 500 Injection

Amifostine (500mg)

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Product Summary :

Amfosted 500 Injection is used to reduce kidney damage caused by cisplatin chemotherapy and the risk of dry mouth following radiotherapy for head and neck cancer in selected patients. It helps protect healthy tissues from treatment-related damage. It is given as an injection into the vein under medical supervision, with adequate hydration and blood pressure monitoring. Common side effects include low blood pressure, nausea and vomiting. It may also lower calcium levels.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 04 Nov 2026 | 01:34 PM (IST)

₹3834 MRP ₹4260.9410% off

(Inclusive of applicable taxes)

Gurgaon

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General Information

Contains

Amifostine (500mg)

Marketer

Therdose Pharma Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Amfosted 500 Injection is used to prevent dryness in the mouth after radiotherapy of head and neck cancer. It reduces the harmful effect of chemotherapy on the kidneys during treatment with cisplatin (medicines used to treat cancer).

Amfosted 500 Injection is given as an injection into vein (IV infusion) under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Nausea, vomiting, and decreased blood pressure. Consult with your doctor if it does not go away or bothers you. It is advised to stay hydrated before taking this medicine. You will be check for blood pressure before infusion and every 5 minutes during infusion.

Before taking it, tell your doctor if you have heart diseases such as irregular heartbeat and heart failure, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.

Uses of Amfosted Injection

Treatment of Dryness in the mouth after radiotherapy of head and neck cancer

Benefits of Amfosted Injection

Treatment of Dryness in the mouth after radiotherapy of head and neck cancer
Amfosted 500 Injection is used to decrease dryness in the mouth caused by radiation treatment after surgery for head and neck cancer. It protects the kidneys from harmful effects of the chemotherapy medicine cisplatin in patients that receive this medication for the treatment of ovarian cancer. It is given as an injection by a doctor or nurse and should not be self-administered.

Side effects of Amfosted Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Amfosted

Hypotension (low blood pressure)

How to use Amfosted Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Amfosted Injection works

Amfosted 500 Injection works by removing free radical, harmful elements produced by cisplatin (a medicine used to treat cancer) or radiation therapy in tissues.

Dosage

Amfosted 500 Injection is given as an injection into the vein by a trained healthcare professional. The dose and timing depend on whether it is being used to protect the kidneys during chemotherapy or to reduce dry mouth during radiotherapy. It is usually given before the cancer treatment. Follow the treatment schedule prescribed by your doctor.

Quick tips

Amfosted 500 Injection is given as an infusion into the vein ( IV infusion) under the supervision of a doctor only.
It is advisable to stay hydrated or drink plenty of fluids before taking medicine.
You will be monitored for blood pressure before and after every 5 minutes of infusion.
It may cause a decrease in calcium levels. Your doctor may monitor your calcium levels regularly and prescribe supplements if needed.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Amfosted 500 Injection. Please consult your doctor.

Pregnancy

UNSAFE

Amfosted 500 Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Amfosted 500 Injection during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Amfosted 500 Injection may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Amfosted 500 Injection in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Amfosted 500 Injection in patients with liver disease.

Interaction with drugs

Taking Amfosted with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Mild

Eplerenone (Oral Route)

Get up slowly if you feel faint and dizzy upon standing.

Frequently asked questions

What is Amfosted 500 Injection used for?

Amfosted 500 Injection is used to protect healthy tissues from certain side effects of cancer treatment. It may help reduce kidney damage caused by cisplatin chemotherapy and prevent moderate to severe dry mouth in selected patients receiving radiotherapy for head and neck cancer.

How is Amfosted 500 Injection given?

Amfosted 500 Injection is given as an injection into a vein by a healthcare professional. It is administered before the scheduled chemotherapy or radiotherapy session, depending on the reason for treatment.

Why is my blood pressure monitored during Amfosted 500 Injection infusion?

Amfosted 500 Injection can cause a sudden fall in blood pressure. Your blood pressure may be checked before, during and after the infusion to identify and manage this reaction promptly.

Why should I drink fluids before receiving Amfosted 500 Injection?

Adequate hydration helps reduce the risk of low blood pressure during the infusion. Your healthcare team will assess your fluid status and advise you on how much fluid you should receive, particularly if you have heart or kidney problems.

Can Amfosted 500 Injection affect calcium levels?

Yes. Amfosted 500 Injection may lower the calcium level in your blood. Your doctor may monitor your calcium levels, particularly if you receive repeated doses or have other risk factors. Calcium supplements may be prescribed if needed.

Can Amfosted 500 Injection cause nausea and vomiting?

Yes. Nausea and vomiting are common side effects and may sometimes be severe. Your doctor may give you medicines to prevent or control them before the infusion.

Can Amfosted 500 Injection be given with blood pressure medicines?

Amfosted 500 Injection may cause a drop in blood pressure. Medicines used to treat high blood pressure may increase this risk. Inform your doctor about all medicines you take so that your treatment can be planned safely.

What should I do if I feel dizzy during the Amfosted 500 Injection infusion?

Inform your healthcare professional immediately if you feel dizzy, faint or unusually weak during the infusion. These may be signs of low blood pressure. Do not try to stand or walk without assistance.

What symptoms should I report immediately during or after the infusion?

Immediately inform your healthcare team if you experience severe dizziness, fainting, difficulty breathing, chest discomfort, skin rash or swelling. These may indicate a serious drop in blood pressure or an allergic reaction.

Fact Box

Chemical Class

Organothiophosphorus compounds

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Cytoprotective agents- Kidney & Salivary gland

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 50-51.
Amifostine. Nijmegen, Netherlands: USB Pharma B.V.; 1999. [Accessed 26 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Amifostine. Malvern, PA: Clinigen, Inc.; 2024. [Accessed 09 Sep. 2026] (online). Available from:
Amifostine. Malvern, PA: Legacy Pharma USA Inc.; 2026. [Accessed 02 Nov 2026] (online). Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Therdose Pharma Pvt Ltd
Address: Plot No's : 118 - 120, Road No.6, ALEAP IE, Pragathi Nagar, Gajularamaram Village, Kukatpally, Hyderabad ,Telangana - 500 072, India.

Vendor Details

Country of origin: India

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Amfosted 500 Injection

Amfosted 500 Injection

Product Summary :

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Amfosted Injection

Benefits of Amfosted Injection

Side effects of Amfosted Injection

How to use Amfosted Injection

How Amfosted Injection works

Dosage

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Eplerenone (Oral Route)

Frequently asked questions

What is Amfosted 500 Injection used for?

How is Amfosted 500 Injection given?

Why is my blood pressure monitored during Amfosted 500 Injection infusion?

Why should I drink fluids before receiving Amfosted 500 Injection?

Can Amfosted 500 Injection affect calcium levels?

Can Amfosted 500 Injection cause nausea and vomiting?

Can Amfosted 500 Injection be given with blood pressure medicines?

What should I do if I feel dizzy during the Amfosted 500 Injection infusion?

What symptoms should I report immediately during or after the infusion?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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