Amfosted 500 Injection

Amifostine (500mg)

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Amfosted 500 Injection is used to prevent dryness in the mouth after radiotherapy of head and neck cancer. It reduces the harmful effect of chemotherapy on the kidneys during treatment with cisplatin (medicines used to treat cancer).

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)

₹3886 MRP ₹4260.949% off

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General Information

Contains

Amifostine (500mg)

Marketer

Therdose Pharma Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Amfosted 500 Injection is given as an injection into vein (IV infusion) under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Nausea, vomiting, decreased blood pressure, sleepiness, dizziness, and flushing are some common side effects of this medicine. Consult with your doctor if it does not go away or bothers you. It is advised to stay hydrated before taking this medicine. You will be check for blood pressure before infusion and every 5 minutes during infusion.

Before taking it, tell your doctor if you have heart diseases such as irregular heartbeat and heart failure, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.

Uses of Amfosted Injection

Treatment of Dryness in the mouth after radiotherapy of head and neck cancer

Benefits of Amfosted Injection

Treatment of Dryness in the mouth after radiotherapy of head and neck cancer
Amfosted 500 Injection is used to decrease dryness in the mouth caused by radiation treatment after surgery for head and neck cancer. It protects the kidneys from harmful effects of the chemotherapy medicine cisplatin in patients that receive this medication for the treatment of ovarian cancer. It is given as an injection by a doctor or nurse and should not be self-administered.

Side effects of Amfosted Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Amfosted

Nausea
Vomiting
Decreased blood pressure
Hiccup
Sleepiness
Dizziness
Flushing (sense of warmth in the face, ears, neck and trunk)
Fever
Chills

How to use Amfosted Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Amfosted Injection works

Amfosted 500 Injection works by removing free radical, harmful elements produced by cisplatin (a medicine used to treat cancer) or radiation therapy in tissues.

Quick tips

Amfosted 500 Injection is given as an infusion into the vein ( IV infusion) under the supervision of a doctor only.
It is advisable to stay hydrated or drink plenty of fluids before taking medicine.
You will be monitored for blood pressure before and after every 5 minutes of infusion.
It may cause a decrease in calcium levels. Your doctor may monitor your calcium levels regularly and prescribe supplements if needed.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Amfosted 500 Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Amfosted 500 Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Amfosted 500 Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

CONSULT YOUR DOCTOR

It is not known whether Amfosted 500 Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

SAFE IF PRESCRIBED

Amfosted 500 Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Amfosted 500 Injection in patients with liver disease.

Interaction with drugs

Taking Amfosted with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Mild

Eplerenone (Oral Route)

Get up slowly if you feel faint and dizzy upon standing.

Frequently asked questions

Is Amfosted 500 Injection FDA approved?

Yes, it is FDA an approved drug

What is Amfosted 500 Injection used for?

Amfosted 500 Injection is used to reduce toxicity to kidneys associated with cisplatin therapy in patients with advanced ovarian cancer, and in prevention of dry mouth (xerostomia) during radiotherapy for head and neck cancer

How does Amfosted 500 Injection work?

It protects the normal cells against the harmful effects of chemotherapy medications and radiation treatment by producing a chemical ‘thiol' that binds to and detoxifies the harmful compounds produced by cisplatin. Amfosted 500 Injection does not interfere with the action of cisplatin.

Fact Box

Chemical Class

Organothiophosphorus compounds

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Cytoprotective agents- Kidney & Salivary gland

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 50-51.
Amifostine. Nijmegen, Netherlands: USB Pharma B.V.; 1999. [Accessed 26 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Therdose Pharma Pvt Ltd
Address: Plot No's : 118 - 120, Road No.6, ALEAP IE, Pragathi Nagar, Gajularamaram Village, Kukatpally, Hyderabad ,Telangana - 500 072, India.

Vendor Details

Country of origin: India

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Amfosted 500 Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Amfosted Injection

Benefits of Amfosted Injection

Side effects of Amfosted Injection

How to use Amfosted Injection

How Amfosted Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Eplerenone (Oral Route)

Frequently asked questions

Is Amfosted 500 Injection FDA approved?

What is Amfosted 500 Injection used for?

How does Amfosted 500 Injection work?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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