Advan-THF Cream

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 09 Feb 2026 | 07:03 PM (IST)

Advan-THF Cream is a medicine that contains a combination of medicines that is used to treat melasma. It helps in quick skin renewal. It provides relief from redness, swelling, and itching.

Genuine

Authenticity Assured

Prescription

required

₹275 MRP ₹316.6913% off

Advan-THF Cream is currently sold out

Same composition alternative:

GLomela Cream

₹277~~₹318.75~~

25% cheaper alternative available

Sold out

Advan-THF Cream

tube of 15 gm Cream

₹275

~~₹316.69~~

Same composition

GLomela Cream

tube of 20 gm Cream

Hydroquinone (2% w/w) + Tretinoin (0.025% w/w) + Fluocinolone acetonide (0.01% w/w)

by Intas Pharmaceuticals Ltd

Get by 7pm

₹277

₹11.75 per gm

₹235

order for

₹1200

Save more with additional offers

Assured cashback up to ₹300 on minimum payment of ₹300 using Paytm UPI*

10% cashback up to 200 on Min Transaction of Rs.1000, for first time users of Airtel Payments Bank.

Pay with Amazon Pay Balance and get cashback up to Rs. 100 with minimum cashback of Rs. 20

Assured cashback up to ₹300 on minimum payment of ₹300 using Paytm UPI*

10% cashback up to 200 on Min Transaction of Rs.1000, for first time users of Airtel Payments Bank.

Pay with Amazon Pay Balance and get cashback up to Rs. 100 with minimum cashback of Rs. 20

Earn cashback up to Rs. 100 with Amazon Pay Later

Get cashback up to ₹500

Get upto Rs.500 Cashback on minimum transaction of Rs.999/- with Mobikwik Wallet.

Get upto Rs.150 Cashback

General Information

Contains

Hydroquinone (2% w/w)+ Tretinoin (0.025% w/w)+ Fluocinolone acetonide (0.01% w/w)

Marketer

Alembic Pharmaceuticals Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Advan-THF Cream should be used in the dose and duration as advised by your doctor. Wash your hands before using this medicine. It is advised to check the label for directions before use. Do not use this medicine more than the recommended dose. Inform your doctor if you have known allergies to this medicine.

Common side effects of this medicine include burning, irritation, itching, and redness at the site of application. It may also cause dry skin, acne, and itching. If any of these side effects bother you or get worse, consult your doctor.

Inform your doctor if you are pregnant or are suffering from any other disease. Caution is needed while breastfeeding; this medicine is not recommended unless advised by your doctor. Do not use this medicine if you have a history of allergic reactions to any of the ingredients in this product.

Uses of Advan-THF Cream

Melasma

Side effects of Advan-THF Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Advan-THF

Burning sensation
Dryness
Erythema (skin redness)
Itching
Skin peeling
Dry skin
Acne

How to use Advan-THF Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Advan-THF Cream works

Advan-THF Cream is a combination of three medicines: Hydroquinone, Tretinoin and Fluocinolone acetonide which treat melasma (dark spots on skin). The exact way this triple combination improves melasma is not fully known. Hydroquinone helps reduce melanin (skin pigment), tretinoin promotes skin cell turnover, and fluocinolone acetonide reduces skin inflammation.

All substitutes for Advan-THF Cream

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Along with applying Advan-THF Cream, wear long-sleeved clothing, sunglasses, or a hat whenever you step outside in the hot sun for better protection.
Do not cover the area being treated with airtight dressings unless instructed by a doctor.
Use moisturizer regularly to overcome skin dryness during the course of treatment.
You may also use certain safe cosmetics (after consulting with your doctor) to lighten pigmentation.
Before using Advan-THF Cream, inform your doctor if you have any skin problems or are applying any other medicines to your skin.

Safety advice

Alcohol

No interaction found/established

Pregnancy

UNSAFE

Advan-THF Cream is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

SAFE IF PRESCRIBED

Advan-THF Cream may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

Frequently asked questions

What is Advan-THF Cream used for?

Advan-THF Cream is prescribed for the short-term treatment of moderate to severe melasma, a dark, patchy discoloration on the face. It helps lighten those spots when used along with sun protection, avoiding sunlight.

Can Advan-THF Cream be used for other dark spots or skin lightening?

No. Advan-THF Cream is only approved for facial melasma. It has not been proven safe or effective for other pigment problems like freckles, age spots, or acne marks.

Is Advan-THF Cream meant for long-term use?

No. Advan-THF Cream is for short-term use only. Once your dark patches improve, your doctor may suggest stopping and switching to other maintenance options. Using it continuously may increase the risk of skin side effects.

What precautions should I take while using Advan-THF Cream?

While you are on Advan-THF Cream therapy, you should avoid direct sunlight exposure, UV lamps, always apply sunscreen (SPF 30 or higher), wear protective clothing, do not use on broken or irritated skin, avoid using harsh soaps, astringents, products that cause dryness, or peeling.

Can Advan-THF Cream cause allergic reactions?

Advan-THF Cream may rarely trigger serious allergic or asthma-like reactions in sensitive people. If you experience swelling, wheezing, or severe itching, stop using it and get medical help immediately.

What is “exogenous ochronosis” and why is it important to know for people using Advan-THF Cream?

Exogenous ochronosis is a blue-black darkening of the skin that can happen with long-term use of hydroquinone (present in Advan-THF Cream). It is rare but may be permanent. If your skin starts getting darker instead of lighter, stop using the medicine and contact your doctor.

Can Advan-THF Cream thin my skin or affect hormones?

Yes, with prolonged or excessive use, the corticosteroid (fluocinolone) present in Advan-THF Cream can cause skin thinning or, in rare cases, hormonal (adrenal) effects. Use it exactly as directed, usually once daily, only for a short time.

Are there any serious side effects of Advan-THF Cream?

Serious side effects of Advan-THF Cream may include severe burning, swelling, blistering of the skin, worsening pigmentation, signs of infection, skin thinning, and any allergic reaction (rash, difficulty breathing, facial swelling). Seek immediate medical attention if you notice any symptoms.

Can people with darker skin tones use Advan-THF Cream safely?

Advan-THF Cream has not been well-studied in very dark skin types (Fitzpatrick V-VI). Over-bleaching, uneven lightening may occur. Your dermatologist can guide you on whether it is appropriate.

What happens if I stop using Advan-THF Cream after improvement?

Melasma often comes back after stopping Advan-THF Cream. To maintain results, continue sun protection, and follow your doctor’s advice on safer long-term maintenance options.

Fact Box

Habit Forming

Therapeutic Class

DERMA

References

Fluocinolone acetonide, hydroquinone, and tretinoin [Prescribing Information]. Canada: G Production Inc.; 2014. [Accessed 29 Apr. 2019] (online) Available from:
Fluocinolone acetonide + hydroquinone + tretinoin [Prescribing Information]. Canada: G Production Inc.; 2013. [Accessed 29 Apr. 2019] (online) Available from:
CiplaMed. Fluocinolone acetonide + Hydroquinone + Tretinoin [Prescribing Information]. [Accessed 14 Aug. 2024] (online) Available from:
Fluocinolone acetonide, hydroquinone, tretinoin [Prescribing Information]. Dallas, TX: Galderma Laboratories, LP; 2023.

User feedback

Patients taking Advan-THF Cream

Once A Day

88%

Twice A Day

Thrice A week

Twice A Week

Alternate Day

What are you using Advan-THF Cream for?

Melasma

71%

Others

16%

Hyperpigmentation

10%

Skin disorders

How much was the improvement?

Poor

52%

Excellent

30%

Average

19%

What were the side-effects while using Advan-THF Cream?

No Side Effect

83%

Application site reactions (burning, irritation, itching and redness)

17%

How do you take Advan-THF Cream?

With or without food

100%

Please rate Advan-THF Cream on price

Average

83%

Not Expensive

17%

Want to know more

We provide you with authentic, trustworthy and relevant information

Have issue with the content

Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alembic Pharmaceuticals Ltd
Address: Alembic Road, Vadodara - 390 003, Gujarat,INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Advan-THF Cream

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Advan-THF Cream

Side effects of Advan-THF Cream

How to use Advan-THF Cream

How Advan-THF Cream works

All substitutes for Advan-THF Cream

Clearz Max Cream

Cutilite Cream

GLomela Cream

Melapik Plus Cream

I Glow Night Cream

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Advan-THF Cream used for?

Can Advan-THF Cream be used for other dark spots or skin lightening?

Is Advan-THF Cream meant for long-term use?

What precautions should I take while using Advan-THF Cream?

Can Advan-THF Cream cause allergic reactions?

What is “exogenous ochronosis” and why is it important to know for people using Advan-THF Cream?

Can Advan-THF Cream thin my skin or affect hormones?

Are there any serious side effects of Advan-THF Cream?

Can people with darker skin tones use Advan-THF Cream safely?

What happens if I stop using Advan-THF Cream after improvement?

Fact Box

Habit Forming

Therapeutic Class

References

User feedback

Patients taking Advan-THF Cream

What are you using Advan-THF Cream for?

How much was the improvement?

What were the side-effects while using Advan-THF Cream?

How do you take Advan-THF Cream?

Please rate Advan-THF Cream on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests