
Acenext Plus 100mg/325mg Tablet
Written By Dr. Subita Alagh, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 07 Apr 2026 | 11:10 AM (IST)
Acenext Plus 100mg/325mg Tablet is a pain-relieving medicine. It reduces pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It may also relieve muscle pain, back pain, toothache, or pain in the ear and throat.
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Acenext Plus 100mg/325mg Tablet
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General Information
Contains
Aceclofenac (100mg)+ Paracetamol (325mg)
Marketer
Cadila Pharmaceuticals Ltd
Storage
Store below 30°C
The content is shown in English



Product introduction
Acenext Plus 100mg/325mg Tablet should be taken with or without food. It should be taken regularly as advised by your doctor. Your doctor may change the dose and time between doses according to your pain level and needs. Do not take more or use it for a longer duration than recommended by your doctor.
Some of the common side effects of this medicine include nausea, dizziness, and diarrhea. You should let your doctor know if any of these side effects bother you or if they do not go away with time. Your doctor may help you with ways to reduce or prevent these side effects by prescribing an alternative medicine or adjusting the dose.
Acenext Plus 100mg/325mg Tablet may not be suitable for everyone. Before taking it, let your doctor know if you have any problems with your heart, kidneys, or liver, or if you have stomach ulcers. Also, tell your doctor about all the other medicines you take to ensure they are safe. Pregnant and breastfeeding mothers should consult their doctors before using Acenext Plus 100mg/325mg Tablet.
Some of the common side effects of this medicine include nausea, dizziness, and diarrhea. You should let your doctor know if any of these side effects bother you or if they do not go away with time. Your doctor may help you with ways to reduce or prevent these side effects by prescribing an alternative medicine or adjusting the dose.
Acenext Plus 100mg/325mg Tablet may not be suitable for everyone. Before taking it, let your doctor know if you have any problems with your heart, kidneys, or liver, or if you have stomach ulcers. Also, tell your doctor about all the other medicines you take to ensure they are safe. Pregnant and breastfeeding mothers should consult their doctors before using Acenext Plus 100mg/325mg Tablet.
Uses of Acenext Plus Tablet
- Pain relief : Acenext Plus 100mg/325mg Tablet helps relieve pain in conditions such as headache, body ache, muscle pain, toothache, menstrual cramps, and minor injuries.
Benefits of Acenext Plus Tablet
Pain relief
Acenext Plus 100mg/325mg Tablet is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. Some of the conditions in which Acenext Plus 100mg/325mg Tablet is used are rheumatoid arthritis, osteoarthritis, muscle pain, back pain, toothache, or pain in the ear and throat.
Acenext Plus 100mg/325mg Tablet is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. Some of the conditions in which Acenext Plus 100mg/325mg Tablet is used are rheumatoid arthritis, osteoarthritis, muscle pain, back pain, toothache, or pain in the ear and throat.
Side effects of Acenext Plus Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Acenext Plus
- Nausea
- Diarrhea
- Increased liver enzymes
How to use Acenext Plus Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Acenext Plus 100mg/325mg Tablet may be taken with or without food.
How Acenext Plus Tablet works
Acenext Plus 100mg/325mg Tablet is a combination of two medicines: Aceclofenac and Paracetamol. These medicines work by blocking the action of chemical messengers responsible for pain, fever and inflammation (redness and swelling).
All substitutes for Acenext Plus 100mg/325mg Tablet
For information purposes only. Consult a doctor before taking any medicine.
acimol 100mg/325mg Tablet
by Leeford Healthcare Ltd
₹2.3/tablet
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₹3.38/tablet
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Acenext P 100mg/325mg Tablet
by Cadila Pharmaceuticals Ltd
₹4.01/tablet
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Aldigesic P 100mg/325mg Tablet
by Alkem Laboratories Ltd
₹4.86/tablet
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Acemiz Plus Tablet
by Lupin Ltd
₹8.32/tablet
18% costlier
Quick tips
- Take Acenext Plus 100mg/325mg Tablet with food to reduce the risk of stomach irritation.
- Do not take Acenext Plus 100mg/325mg Tablet with other medicines containing paracetamol without consulting your doctor.
- Avoid taking Acenext Plus 100mg/325mg Tablet with other NSAIDs (such as ibuprofen or diclofenac) unless advised by your doctor.
- Acenext Plus 100mg/325mg Tablet may cause dizziness or sleepiness, so avoid driving or operating machinery until you know how it affects you.
- Avoid alcohol while taking Acenext Plus 100mg/325mg Tablet, as it may increase drowsiness and the risk of liver or stomach problems.
- Stop taking Acenext Plus 100mg/325mg Tablet and seek medical attention if you develop severe stomach pain or black/tarry stools.
- Stay well hydrated while using Acenext Plus 100mg/325mg Tablet, as dehydration may increase the risk of kidney-related side effects.
- Inform your doctor if you have a history of stomach ulcers, kidney disease, or liver disease before taking Acenext Plus 100mg/325mg Tablet.
- Do not increase the dose or frequency of Acenext Plus 100mg/325mg Tablet without medical advice.
- Inform your doctor if you develop a rash, swelling, or signs of an allergic reaction while taking Acenext Plus 100mg/325mg Tablet.
- If dizziness occurs after taking Acenext Plus 100mg/325mg Tablet, avoid activities requiring alertness such as driving.
- If pain persists or keeps recurring despite taking Acenext Plus 100mg/325mg Tablet, consult your doctor for further evaluation.
Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Acenext Plus 100mg/325mg Tablet. Please consult your doctor.

Pregnancy
UNSAFE
Acenext Plus 100mg/325mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding
CONSULT YOUR DOCTOR
Acenext Plus 100mg/325mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving
UNSAFE
Acenext Plus 100mg/325mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney
CAUTION
Acenext Plus 100mg/325mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Acenext Plus 100mg/325mg Tablet is not recommended in patients with severe kidney disease.
Use of Acenext Plus 100mg/325mg Tablet is not recommended in patients with severe kidney disease.

Liver
UNSAFE
Acenext Plus 100mg/325mg Tablet is unsafe to use in patients with liver disease and should be avoided.
However, the use of Acenext Plus 100mg/325mg Tablet is not recommended in patients with severe liver disease and active liver disease.
However, the use of Acenext Plus 100mg/325mg Tablet is not recommended in patients with severe liver disease and active liver disease.
Frequently asked questions
Acenext Plus 100mg/325mg Tablet is a medicine that contains aceclofenac and paracetamol. It is used to relieve pain, swelling, and inflammation in conditions such as arthritis, joint pain, back pain, muscle pain, dental pain, and pain caused by injuries. It works by reducing certain chemicals in the body that cause pain and inflammation. While Acenext Plus 100mg/325mg Tablet helps control pain and discomfort, it does not treat the underlying cause of the condition. It should only be taken as prescribed by your doctor.
If Acenext Plus 100mg/325mg Tablet is prescribed for short-term pain, it can usually be stopped once your symptoms improve. However, if you are taking it for a condition that causes long-term pain, such as arthritis, your doctor may advise continuing it for a specific period. Always follow your doctor’s instructions before stopping the medicine.
Acenext Plus 100mg/325mg Tablet may cause side effects such as nausea, vomiting, stomach pain, heartburn, or dizziness in some people. These symptoms are more likely if the medicine is taken on an empty stomach. In some cases, it may also increase blood pressure or cause fluid retention, especially with repeated use. Rare but serious warning signs include black stools, vomiting blood, or severe stomach pain, which may indicate stomach bleeding. Contact your doctor if side effects persist or become severe.
Acenext Plus 100mg/325mg Tablet should not be taken by people who are allergic to this medicine or to other similar pain relievers known as NSAIDs. It is also not recommended for people with stomach ulcers, active stomach bleeding, severe liver or kidney disease, uncontrolled high blood pressure, or heart failure unless advised by a doctor. It is generally avoided during pregnancy, particularly in the later stages. Always inform your doctor about your medical history before taking Acenext Plus 100mg/325mg Tablet.
Acenext Plus 100mg/325mg Tablet may start reducing pain within a few hours in many people, although the exact timing can vary. The aceclofenac component helps reduce inflammation, while paracetamol helps relieve pain and fever. If you need to take the medicine for several days or if the pain does not improve, the underlying cause may need medical evaluation. If symptoms worsen or persist, consult your doctor.
No, Acenext Plus 100mg/325mg Tablet is not the same as tramadol. Acenext Plus 100mg/325mg Tablet contains an anti-inflammatory medicine and paracetamol, which help reduce pain and inflammation. Tramadol works differently by affecting pain signals in the brain. It also has a higher risk of drowsiness and dependence. Because these medicines work differently and have different side effects, they should not be confused. If you are unsure about your prescription, consult your doctor.
You should not change the dose or frequency of Acenext Plus 100mg/325mg Tablet on your own. Taking it more often than prescribed increases the risk of stomach bleeding, kidney damage, and liver damage. The risk of paracetamol overdose is higher if you also take other medicines that contain paracetamol. Always follow the dose recommended by your doctor.
Acenext Plus 100mg/325mg Tablet is usually better tolerated when taken after food, especially if you are prone to acidity or stomach irritation. Taking it with food can help reduce stomach discomfort because aceclofenac may irritate the stomach lining. Try to take it at a consistent time as advised by your doctor and drink enough fluids unless your doctor advises otherwise.
Early signs of possible kidney problems may include reduced urination, swelling of the feet or face, unusual tiredness, nausea, or rising blood pressure. Although these symptoms can have many causes, they should not be ignored. Anti-inflammatory medicines like aceclofenac may affect kidney function, especially in people who are dehydrated or already have kidney problems. If you notice these symptoms, stop self-medicating and consult your doctor promptly.
It is best to avoid alcohol while taking Acenext Plus 100mg/325mg Tablet. Alcohol can increase the risk of stomach irritation and bleeding due to aceclofenac and may also increase the risk of liver damage when combined with paracetamol. If you regularly consume alcohol, discuss this with your doctor before using Acenext Plus 100mg/325mg Tablet so that a safer treatment plan can be recommended.
Fact Box
Habit Forming
No
Therapeutic Class
PAIN ANALGESICS
References
- Furst DE, Ulrich RW, Prakash S, et al. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 621-642.
- Grosser T, Smyth EM, FitzGerald GA. Pharmacotherapy of Inflammation, Fever, Pain, and Gout. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill Education; 2018. pp. 685-709.
- Eraas International. Aceclofenac+Paracetamol [Product Information]. [Accessed 14 Aug. 2024] (online) Available from:
- Aceclofenac And Paracetamol. Zuventus; [Accessed 14 Aug. 2024] (online). Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Cadila Pharmaceuticals Ltd
Address: Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.
Address: Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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