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Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate

Hydroquinone (20mg)+ Tretinoin (0.25mg)+ Fluocinolone acetonide (0.5mg)

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Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate is a medicine that contains a combination of medicines that is used to treat melasma. It helps in quick skin renewal. It provides relief from redness, swelling, and itching.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 02 Apr 2026 | 05:32 PM (IST)

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General Information

Contains

Hydroquinone (20mg)+ Tretinoin (0.25mg)+ Fluocinolone acetonide (0.5mg)

Marketer

Ajanta Pharma Limited

Storage

Store below 25°C

Preservative

Methylparaben, Propyl paraben

The content is shown in English

Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate image

Product introduction

Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate should be used in the dose and duration as advised by your doctor. Wash your hands before using this medicine. It is advised to check the label for directions before use. Do not use this medicine more than the recommended dose. Inform your doctor if you have known allergies to this medicine.

Common side effects of this medicine include burning, irritation, itching, and redness at the site of application. It may also cause dry skin, acne, and itching. If any of these side effects bother you or get worse, consult your doctor.

Inform your doctor if you are pregnant or are suffering from any other disease. Caution is needed while breastfeeding; this medicine is not recommended unless advised by your doctor. Do not use this medicine if you have a history of allergic reactions to any of the ingredients in this product.

Uses of Melrio Cream

Melasma

Side effects of Melrio Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Melrio

Burning sensation
Dryness
Erythema (skin redness)
Itching
Skin peeling
Dry skin
Acne

How to use Melrio Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Melrio Cream works

Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate is a combination of three medicines: Hydroquinone, Tretinoin and Fluocinolone acetonide which treat melasma (dark spots on skin). The exact way this triple combination improves melasma is not fully known. Hydroquinone helps reduce melanin (skin pigment), tretinoin promotes skin cell turnover, and fluocinolone acetonide reduces skin inflammation.

Quick tips

Along with applying Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate, wear long-sleeved clothing, sunglasses, or a hat whenever you step outside in the hot sun for better protection.
Do not cover the area being treated with airtight dressings unless instructed by a doctor.
Use moisturizer regularly to overcome skin dryness during the course of treatment.
You may also use certain safe cosmetics (after consulting with your doctor) to lighten pigmentation.
Before using Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate, inform your doctor if you have any skin problems or are applying any other medicines to your skin.

Safety advice

Alcohol

No interaction found/established

Pregnancy

UNSAFE

Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

SAFE IF PRESCRIBED

Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

Frequently asked questions

What is Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate used for?

Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate is prescribed for the short-term treatment of moderate to severe melasma, a dark, patchy discoloration on the face. It helps lighten those spots when used along with sun protection, avoiding sunlight.

Can Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate be used for other dark spots or skin lightening?

No. Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate is only approved for facial melasma. It has not been proven safe or effective for other pigment problems like freckles, age spots, or acne marks.

Is Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate meant for long-term use?

No. Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate is for short-term use only. Once your dark patches improve, your doctor may suggest stopping and switching to other maintenance options. Using it continuously may increase the risk of skin side effects.

What precautions should I take while using Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate?

While you are on Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate therapy, you should avoid direct sunlight exposure, UV lamps, always apply sunscreen (SPF 30 or higher), wear protective clothing, do not use on broken or irritated skin, avoid using harsh soaps, astringents, products that cause dryness, or peeling.

Can Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate cause allergic reactions?

Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate may rarely trigger serious allergic or asthma-like reactions in sensitive people. If you experience swelling, wheezing, or severe itching, stop using it and get medical help immediately.

What is “exogenous ochronosis” and why is it important to know for people using Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate?

Exogenous ochronosis is a blue-black darkening of the skin that can happen with long-term use of hydroquinone (present in Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate). It is rare but may be permanent. If your skin starts getting darker instead of lighter, stop using the medicine and contact your doctor.

Can Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate thin my skin or affect hormones?

Yes, with prolonged or excessive use, the corticosteroid (fluocinolone) present in Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate can cause skin thinning or, in rare cases, hormonal (adrenal) effects. Use it exactly as directed, usually once daily, only for a short time.

Are there any serious side effects of Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate?

Serious side effects of Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate may include severe burning, swelling, blistering of the skin, worsening pigmentation, signs of infection, skin thinning, and any allergic reaction (rash, difficulty breathing, facial swelling). Seek immediate medical attention if you notice any symptoms.

Can people with darker skin tones use Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate safely?

Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate has not been well-studied in very dark skin types (Fitzpatrick V-VI). Over-bleaching, uneven lightening may occur. Your dermatologist can guide you on whether it is appropriate.

What happens if I stop using Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate after improvement?

Melasma often comes back after stopping Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate. To maintain results, continue sun protection, and follow your doctor’s advice on safer long-term maintenance options.

Fact Box

Habit Forming

Therapeutic Class

DERMA

References

Fluocinolone acetonide, hydroquinone, and tretinoin [Prescribing Information]. Canada: G Production Inc.; 2014. [Accessed 29 Apr. 2019] (online) Available from:
Fluocinolone acetonide + hydroquinone + tretinoin [Prescribing Information]. Canada: G Production Inc.; 2013. [Accessed 29 Apr. 2019] (online) Available from:
CiplaMed. Fluocinolone acetonide + Hydroquinone + Tretinoin [Prescribing Information]. [Accessed 14 Aug. 2024] (online) Available from:
Fluocinolone acetonide, hydroquinone, tretinoin [Prescribing Information]. Dallas, TX: Galderma Laboratories, LP; 2023.

User feedback

Patients taking Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: A)ajanta pharma limited
Address: A)Plot No. T-68, T-68(PT), T-63, MIDC, Tarapur, Boisar (W) - 401502, Tal: MIDC Tarapur Boisar, Dist: Palghar Regd Office: Ajanta House, Charkop, Kandivli (W), Mumbai 400 067

Marketer details

Name: Ajanta Pharma Limited
Address: Ajanta House, Charkop, Kandivli West, Mumbai 400 067, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate

Save more with additional offers

General Information

Contains

Marketer

Storage

Preservative

Product introduction

Uses of Melrio Cream

Side effects of Melrio Cream

How to use Melrio Cream

How Melrio Cream works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate used for?

Can Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate be used for other dark spots or skin lightening?

Is Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate meant for long-term use?

What precautions should I take while using Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate?

Can Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate cause allergic reactions?

What is “exogenous ochronosis” and why is it important to know for people using Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate?

Can Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate thin my skin or affect hormones?

Are there any serious side effects of Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate?

Can people with darker skin tones use Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate safely?

What happens if I stop using Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate after improvement?

Fact Box

Habit Forming

Therapeutic Class

References

User feedback

Patients taking Melrio Cream with Hydroquinone, Tretinoin and Fluticasone Propionate

Want to know more

Have issue with the content

Disclaimer

Manufacturer details

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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