Naproxen + Domperidone is a combination of two medicines: Naproxen + Domperidone1 and Naproxen + Domperidone2. Naproxen + Domperidone1 is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause pain due to migraine. Naproxen + Domperidone2 is a prokinetic which works on the region in the brain that controls vomiting associated with migraine. It also increases the movement of the stomach and intestines, allowing food to move more easily through the stomach.
Xenadom is a combination of two medicines: Naproxen and Domperidone. This combination helps in relieving the symptoms of migraine like headache, nausea and vomiting. Naproxen is a pain-killer that blocks the release of certain chemical messengers that cause headache. Domperidone is an anti-emetic agent (prokinetic). It increases the movement of the stomach and intestines, allowing food to move more easily through the stomach. This helps in relieving vomiting.
Q. Can I stop taking Xenadom when my migraine symptoms are relieved?
No, do not stop taking Xenadom until advised by your doctor.
Q. Can the use of Xenadom cause diarrhea?
Yes, the use of Xenadom can cause diarrhea. In case, you experience diarrhea, drink plenty of water or other fluids. Talk to your doctor if diarrhea persists and you notice any signs of dehydration, like less urination with dark coloured and strong-smelling urine. Do not take any other medicine without consulting a doctor.
Q. Are there any specific contraindications associated with the use of Xenadom?
The use of Xenadom is considered to be harmful for patients with known allergy to any of the components or excipients of this medicine or in patients with known allergy to other painkillers (NSAIDs). The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer/bleeding. It should also be avoided in patients with history of heart failure, high blood pressure, and liver or kidney disease.
Q. Can the use of Xenadom cause damage to kidneys?
Yes, the long-term use of Xenadom can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protects them from damage. Use of painkillers lower the levels of prostaglandins in the body, which leads to kidney damage on long-term use. Use of painkillers is not recommended to patients with underlying kidney disease.
Q. Can I take a higher than the recommended dose of Xenadom?
No, taking a higher than the recommended dose of Xenadom can increase the risks of side effects. If you are experiencing increased severity of migraine attacks which are not relieved by the recommended doses, please consult your doctor for re-evaluation.
Q. What are the recommended storage conditions for Xenadom?
Keep this medicine in the container or the pack it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 19th Nov 2018. The medicine details are for information purpose only. Consult a doctor before taking any medicine.