Rifampicin + Isoniazid is a combination of two antibiotics: Rifampicin + Isoniazid1 and Rifampicin + Isoniazid2, which treats tuberculosis (TB). Rifampicin + Isoniazid1 works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Rifampicin + Isoniazid2 prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
Q. What are the instructions for storage and disposal of Rifica Plus?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. What is Rifica Plus?
Rifica Plus is a combination of two medicines: Rifampicin and Isoniazid. It is used in the treatment of tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by tuberculosis bacteria to make essential proteins and reproduce. Isoniazid prevents the tuberculosis causing bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
Q. What is the most important information I should know about the Rifica Plus?
Take the proper course of drug that has been prescribed to you. Do not stop in between even if you begin to feel better. Avoid alcohol while taking this medicine as it increases the risk of damage to your liver during treatment. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.
Q. What is the best time to take Rifica Plus?
Take Rifica Plus exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.
Q. Does Rifica Plus cause change in urine color/turn urine orange?
Yes, Rifica Plus can change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful.
Q. Does the use of Rifica Plus make birth control pills ineffective?
Yes, Rifica Plus can make birth control pills less effective. So, ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm and spermicide).
Information last updated by Dr. Varun Gupta, MD Pharmacology on 18th Feb 2020. The medicine details are for information purpose only. Consult a doctor before taking any medicine.