Q. Does Combutol cause blindness?
Optic neuritis (inflammation of nerve fibers that transmit visual information from your eye to the brain) is one of the side effects of Combutol which causes several forms of eye defect. Although these conditions are reversible upon discontinuation of the drug, rare cases of irreversible blindness have also been reported. Please contact your doctor immediately if you notice any of these symptoms: decreased clearness of vision, loss of vision, disturbed vision due to blind spots, color blindness, visual field defect and eye pain
Q. Does Combutol induce hyperuricemia/how does Combutol induce hyperuricemia?
Yes. Increase in blood levels of uric acid is a side effect of Combutol. It increases the retention of uric acid in the body by decreasing the excretion of urates (uric acid) by the kidneys
Q. How does Combutol work in the body?
Combutol is an antibiotic effective against tuberculosis causing bacteria. It suppresses the growth of the bacteria by interfering with the formation of the outer protective covering (cell wall) of the bacteria, thereby weakening the bacteria
Q. What is Combutol toxicity/How does Combutol cause optic neuritis/how does Combutol affect vision?
Combutol toxicity involves toxic effects on the eyes (optic neuritis/optic neuropathy) which are related to the dose and duration of Combutol treatment. It causes optic neuritis (inflammation of nerve fibers in the eye) by interfering with important cellular activities (mitochondrial toxicity) in the nerve cells and inducing nerve damage (neuropathy) thereby affecting the transmission of visual information from the eye to brain. The symptoms of Combutol induced optic neuritis include: decreased clearness of vision, loss of vision, disturbed vision due to blind spots, color blindness, visual field defect and eye pain
Q. What does Combutol treat?
Combutol is an antibiotic effective against tuberculosis causing bacteria. It is used in the prevention, treatment and second time treatment of tuberculosis (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)
Q. Is Combutol bacteriostatic or bactericidal?
Combutol is both a bacteriostatic and a bactericidal antibiotic. It suppresses the growth of bacteria (bacteriostatic) by interfering with the formation of the outer protective covering (cell wall) of the bacteria, thereby weakening it and causing cell death in certain cases (bactericidal)
Q. Is Combutol hepatotoxic?
Liver toxicities are among the known side effects of Combutol. Inflammation of liver (hepatitis), abnormal liver function causing yellowing of skin and eyes (jaundice), abnormal liver function tests (blood tests to assess health of liver) and very rarely liver failure have been noted in patients receiving multi drug (including Combutol) treatment for tuberculosis. Please contact your doctor before taking Combutol if you have any liver problems
Q. Is Combutol toxicity reversible?
In most cases Combutol toxicities are related to dose (depends upon the quantity of Combutol you take) and duration of treatment and are reversible upon discontinuation. However, serious irreversible damage to eye and liver has been reported in rare cases
Q. Is Combutol chemotherapy?
Combutol is an antibiotic used in the treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer
Q. Combutol is effective against?
Combutol is effective against most tuberculosis causing bacteria belonging to Mycobacterium family (M. tuberculosis, M. avium complex, M. kansasii, M. marinum).