
tTG (Tissue Transglutaminase) - IgG antibody near me in Thane










The tTG (Tissue Transglutaminase) - IgG antibody test helps diagnose celiac disease, a condition where the body reacts to gluten. This test checks for IgG antibodies in the blood that are made when the body reacts to an enzyme called tissue transglutaminase (tTG), which is involved in normal protein processes. It is widely available with Tata 1mg labs at an affordable price in Thane.
Doctors may suggest the tTG (Tissue Transglutaminase) - IgG antibody test when there are symptoms of celiac disease, such as stomach pain, bloating, chronic diarrhea, weight loss, failure to thrive (in children), anemia, dermatitis herpetiformis (an itchy, blistery rash), etc. This test is particularly used as an alternative for people who have an IgA deficiency, as they may not get accurate results. It can also be done to monitor the effectiveness of a gluten-free diet. Additionally, it is useful for screening individuals at higher risk, such as those with a family history of celiac disease or other autoimmune conditions.
No special preparation is required before undertaking the tTG (Tissue Transglutaminase) - IgG antibody test. For accurate diagnosis, continue to eat foods that contain gluten for a time period, such as several weeks, before testing only if your doctor advises. The adult patient eats high amounts of gluten (usually 8-10 gm of gluten per day, equivalent to approximately 4-6 slices of bread a day) for 6-8 weeks. This gluten dose can be gradually built up over the first week. A repeat celiac screening test is done after the gluten challenge. This type of challenge can be poorly tolerated by patients, and thus, some may be resistant to this approach.








What does tTG (Tissue Transglutaminase) - IgG antibody measure?
The tTG (Tissue Transglutaminase) - IgG antibody test measures IgG antibodies against tissue transglutaminase (tTG) enzyme, representing an autoimmune response triggered by gluten in celiac disease. This test is specifically valuable for the 2-3% of celiac patients with selective IgA deficiency, for whom standard IgA testing would be unreliable.
Elevated IgG anti-tTG levels suggest celiac disease in IgA-deficient individuals. A conclusive diagnosis requires additional investigations.
Early detection and treatment can prevent complications, including iron-deficiency anemia, vitamin deficiencies, growth retardation in children, osteoporosis, and increased lymphoma risk.





FAQs related to tTG (Tissue Transglutaminase) - IgG antibody in Thane
- Di Sabatino A, Vanoli A, Giuffrida P, Luinetti O, Solcia E, Corazza GR. The function of tissue transglutaminase in celiac disease. Autoimmun Rev. 2012 Aug;11(10):746-53. [Accessed 6 May 2025]. Available from:
- Yao Z, Fan Y, Lin L, Kellems RE, Xia Y. Tissue transglutaminase: a multifunctional and multisite regulator in health and disease. Physiol Rev. 2024 Jan 1;104(1):281-325. [Accessed 6 May 2025]. Available from:
- Daley SF, Haseeb M. Celiac Disease. [Updated 2025 Feb 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:
- Dahlbom I, Olsson M, Forooz NK, Sjöholm AG, Truedsson L, Hansson T. Immunoglobulin G (IgG) anti-tissue transglutaminase antibodies used as markers for IgA-deficient celiac disease patients. Clin Diagn Lab Immunol. 2005 Feb;12(2):254-8. [Accessed 6 May 2025]. Available from:
- Makharia GK, Verma AK, Amarchand R, Bhatnagar S, Das P, Goswami A, Bhatia V, Ahuja V, Datta Gupta S, Anand K. Prevalence of celiac disease in the northern part of India: a community based study. J Gastroenterol Hepatol. 2011 May;26(5):894-900. [Accessed 6 May 2025]. Available from:
- Celiac Disease Foundation. Screening [Internet]. Woodland Hills (CA): Celiac Disease Foundation; [Accessed 6 May 2025]. Available from:
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