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Uric Acid, Serum

Uric Acid, Serum

Also referred as
Uric acid
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The Uric Acid, Serum test is a blood test that measures the levels of uric acid, a natural waste product formed from the breakdown of purines (found in certain foods and body tissues). This test is an important indicator of kidney function and metabolic balance and is commonly done as part of a routine health checkup or kidney function test (KFT).

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Understanding Uric Acid, Serum

Normally, uric acid is filtered by the kidneys and removed through urine. When the levels of uric acid in the blood become elevated (called hyperuricemia), it can indicate conditions such as gout, kidney stones, metabolic disorders, or impaired kidney function. Low uric acid levels (called hypouricemia) are less common but may occur due to liver disease or certain metabolic problems.

The Uric Acid, Serum is usually recommended if you experience symptoms like joint pain, swelling, or redness, especially in the big toe or ankles, or if you have a history of kidney stones. Your doctor may also suggest this test if you are at risk due to conditions like diabetes, obesity, high blood pressure, kidney disease, or a family history of gout or kidney stones. This test is also useful for monitoring treatment in individuals with gout, kidney stones, or other uric acid–related disorders.

No special preparations are required for this test. Eat and drink as per your routine. However, inform your doctor about all the current medications or any underlying health conditions to ensure accurate interpretation of your test results.

Test result ranges may vary across the laboratories depending on the methodology and laboratory guidelines. Do not self-medicate. Always consult your doctor to understand your test results correctly.

What are the symptoms or conditions that may require the Uric Acid, Serum test?

You may need the Uric Acid, Serum test:

  • If there are symptoms of gout, such as sudden joint pain (especially in the big toe, ankles, or knees), swelling, redness, or warmth in the joints.
  • If there are symptoms of kidney stones, such as sudden back pain, pain during urination, or blood in urine.
  • You experience unexplained fatigue, weakness, or other metabolic concerns.
  • You are at increased risk due to conditions such as obesity, high blood pressure, diabetes, or a family history of gout or kidney disease.
  • You are taking medications that may affect uric acid levels.

When would I need the Uric Acid, Serum test?

You may need this test :

  • To check for high uric acid (hyperuricemia) or low uric acid (hypouricemia).
  • If you have risk factors like obesity, high blood pressure, diabetes, or a family history of gout or kidney disease.
  • To monitor treatment response for gout, kidney disease, or other metabolic disorders.
  • Before surgeries or medical procedures where kidney function or uric acid levels may be relevant.
  • If you are on medications that could affect uric acid levels.
  • For routine monitoring in individuals with known metabolic or kidney conditions.

How Do I Prepare for the Uric Acid, Serum Test?

Do I need to fast or stop any medications before the Uric Acid, Serum test?

No, fasting is not required before the Uric Acid, Serum test. You can eat and drink normally before the test. However, it is essential to inform your doctor about any medications or supplements you are taking. Certain medications, like diuretics and cancer medications, may interact with test results. Your doctor will guide you if any temporary adjustments are needed before the test.

How is the Uric Acid, Serum test done?

  • The Uric Acid, Serum test is done by collecting a small amount of blood from a vein, usually in the arm.
  • The procedure is quick, minimally invasive, and generally causes only slight discomfort.

What happens before the Uric Acid, Serum test?

  • Fasting is not needed for this test. You can eat and drink normally.
  • Take your medicines as usual. Inform your doctor about any special treatments or supplements.
  • Let your doctor know if you are sick or have had recent blood loss, as this can affect results.
  • Bring a list of your current medications, supplements, and any recent health history.

What happens during the Uric Acid, Serum test?

  • You will be seated comfortably with your arm supported on a flat surface or armrest.
  • A tourniquet (elastic band) is tied around your upper arm to make the veins more visible and easier to locate.
  • The phlebotomist identifies a suitable vein for blood collection.
  • The puncture site is then cleaned thoroughly with an alcohol swab to reduce the risk of infection.
  • A thin, sterile needle is gently inserted into the vein, and a small amount of blood is collected into a test tube.

What happens after the Uric Acid, Serum test?

  • Once enough blood is collected, the tourniquet is released and the needle is removed.
  • A cotton ball or gauze is placed on the site, followed by a small bandage or dressing to stop any bleeding.
  • The blood sample is carefully labeled with your details and sent to the laboratory for analysis.
  • You can resume your daily routine after the test is done.

Is the Uric Acid, Serum test painful?

No, the Uric Acid, Serum test is generally safe and painless. However, you may feel slight discomfort during blood sample collection, but the chances of serious complications are extremely rare.

How Long Does the Uric Acid, Serum Test Take?

The procedure is quick, simple, and safe. It requires only a small blood sample and is completed within a short duration.

When Will I Get the Results?

The availability of your test report may vary depending on your location and the laboratory where the test is conducted. In general, Tata 1mg provides the results within the stipulated time after sample collection.

When Should I Consult a Doctor After the Test?

You should reach out to your doctor promptly if:

  • Your uric acid test results are not within the normal range. 
  • You feel any new or concerning symptoms related to gout. 
  • You experience symptoms related to kidney stones, including severe abdominal or back pain, blood in the urine, or pain during urination.

Are There Any Risks Associated with the Uric Acid, Serum Test?

The Uric Acid, Serum test is safe, with only minimal and short-lasting effects like:

  • Small bruise, pinch, or slight tenderness at the puncture site
  • Occasional lightheadedness if you are sensitive to needles or blood
  • Rarely, infection or blood vessel injury

Note: If you have a bleeding disorder or take blood thinners, inform the phlebotomist beforehand.

Lifestyle Tips to Support Healthy Uric Acid Levels

🥤Hydration: Stay hydrated. Dehydration slows uric acid removal.  

🥗Eat (Diet): Avoid purine-rich foods (e.g., seafood, bacon, beef, lamb, turkey, organ meats, etc.) or fructose-rich foods (e.g., fructose corn syrup, sugar-sweetened drinks, etc.) that raise uric acid amounts.

🚴‍♀️Activity (Exercise): Light exercise lowers serum uric acid concentration by enhancing its metabolism.

👨‍⚕️Talk to Your Doctor (Consult): Always consult a doctor in case your levels are higher or lower than the normal uric acid levels and before taking any medication or making changes in its doses.

🍷Habits (Alcohol): Alcohol, especially beer, has a high purine content that can increase uric acid levels.

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What does Uric Acid, Serum measure?

The Uric Acid, Serum test measures the amount of uric acid in your blood. Uric acid is a waste product formed when the body breaks down purines. Purines are the natural substances found in your body’s cells (DNA) and in certain foods like red meat or seafood. Under normal conditions, uric acid dissolves in the blood, passes through the kidneys, and is excreted in the urine. When this process doesn’t work properly, due to either increased production or reduced elimination, the uric acid can build up in the blood. This may indicate underlying health issues such as kidney dysfunction, gout, or the presence of kidney stones. In some cases, the exact reason for high uric acid levels is unclear. On the other hand, low uric acid levels are rarely a cause for concern. This test helps doctors understand if uric acid levels are within a healthy range and whether further evaluation or treatment is needed.

What Do the Results Mean?

Pathological Factors 

Test Parameter

Interpretation 

Possible causes

  High Uric Acid

Hyperuricemia 

Increased uric acid production due to:

  • Leukemia

  • Multiple myeloma

  • Paget’s disease

  • Psoriasis

  • Chemotherapy

  • Polycythemia vera

  • Lymphoma

  • Hemolysis

  • Sickle cell anemia

  • Pneumonia

Decreased uric acid removal due to:

  • Kidney disorder

  • Metabolic Acidosis

  • Hypovolemia

  • Sarcoidosis

  • Hyperparathyroidism

  • Hypothyroidism

  • Genetic disorders

Both increased production and decreased removal in:

  • Gout

  • Asymptomatic hyperuricemia

Low Uric Acid

Hypouricemia 

Decreased uric acid production due to:

  •  Xanthinuria

Increased uric acid removal due to:

  • Wilson's disease

  • Fanconi syndrome

  • Acromegaly (some patients)

  • Celiac disease (slightly)

  • Neoplasms

Physiological Factors

🧒 Age: Uric acid level rises every 10 years in men. However, it only begins increasing after the age of 50 in women. 

🧑‍🦳 Gender: Men generally have higher uric acid levels than women.

🫄 Pregnancy: Uric acid levels tend to drop during early pregnancy due to hormonal changes. These levels return to normal as the pregnancy progresses.

🩸Menopause: Uric acid levels are higher after menopause due to low estrogen levels. 

Lifestyle Factors

🏃 Exercise: Weight loss and physical exercise lower uric acid levels. 

🥗 Diet: Eating purine-rich foods (such as alcohol, red meat, seafood, etc., and fructose- or sugar-containing beverages) increases the uric acid levels.

😟Stress: Stress can affect blood cortisol levels and thus uric acid concentrations.

💊Medications: Medicines, such as diuretics, immunosuppressants, chemotherapeutic agents, etc., can affect uric acid removal. Therefore, they increase uric acid levels.

Geographical Location: High-altitude regions, such as mountains, can also increase the uric acid production, raising its levels. 

Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.

What Do Normal Uric Acid, Serum Levels Mean?

Normal uric acid levels suggest proper breakdown of purines and uric acid removal. It means your kidneys are working properly. It means that you have a low risk of other health problems like kidney stones, gout, or kidney problems.

What Do High Levels of Uric Acid, Serum Indicate?

High uric acid levels (hyperuricemia) indicate problems in uric acid synthesis or removal. This can happen due to kidney issues and can lead to gout and kidney stones. Also, these levels increase the chances of diabetes, high blood pressure, and heart disease.

What to Do if the Levels Are Higher Than Normal?

If your uric acid levels are higher than normal, it may indicate conditions such as gout, kidney disease, or metabolic disorders. Your doctor will evaluate your symptoms and may suggest lifestyle changes like reducing intake of purine-rich foods, limiting alcohol and sugary drinks, and staying well-hydrated to help flush out excess uric acid.

What Do Low Levels of Uric Acid, Serum Indicate?

Low uric acid levels (hypouricemia) result from increased uric acid removal from the body or decreased production of uric acid. It can occur due to certain medicines or health issues, such as problems in the kidneys, thyroid, or parathyroid glands. Generally, low uric acid levels do not show any symptoms. However, they are associated with muscle weakness, fatigue, and rare genetic disorders. Low uric acid levels are not very common and are often discovered incidentally during routine blood tests. Since low readings can have different causes, always consult a doctor to understand what they mean in your specific case.

Can Uric Acid, Serum Results Be Inaccurate?

Yes. Certain conditions can affect test accuracy. If your uric acid serum test results do not align with your symptoms or overall health, your doctor may recommend repeating the test or ordering additional investigations.

What Factors Can Affect Uric Acid, Serum Results?

Though it is a reliable test, several factors can influence the accuracy:

  • Diet including purine-rich or fructose-containing foods
  • Alcohol
  • Certain medications, like diuretics or immunosuppressants 
  • Pregnancy 
  • Menopause
  • Age
  • Dehydration 
  • Exercise
  • Certain medical conditions, like kidney diseases or cancer

What Follow-Up Tests May Be Required?

Based on your uric acid results, your doctor may recommend additional tests to get a clearer picture of your health or to monitor possible complications. These may include kidney panels, cholesterol testing, or a CBC test.

Table: Tests Commonly Ordered Alongside Uric Acid, Serum: 

Test Name

Primary Purpose

Urinalysis

Measures uric acid in urine to assess kidney stones

KFT

Analyzes kidney health to detect issues with kidney function

CBC

Determines the levels of blood cells to detect the disease behind abnormal uric acid levels

Lipid profile

Measures lipid levels for the presence or risk of other disorders, such as heart disease

HbA1c

Estimates blood sugar for the presence of diabetes

Renal CT scan or ultrasound

Visualizes stones in the kidneys

X-rays

Detect swelling in joints

Joint Aspiration

Analyzes the presence of uric acid crystals in joints

How Does the Uric Acid, Serum Test Differ from Other Kidney Function Tests?

The Uric Acid, Serum test measures the level of uric acid in the blood, which is a byproduct of purine metabolism. Elevated or decreased levels can indicate kidney issues, metabolic disorders, or other health conditions. Other related tests include:

  • Serum Creatinine: Measures creatinine to assess kidney filtration efficiency and overall kidney function.
  • Urine Uric Acid: Measures uric acid excretion in urine to assess kidney function, detect risk of uric acid kidney stones, or evaluate metabolic disorders.
  • BUN/Urea: Gives an idea of how well your kidneys are working. The levels can change with your diet or water intake.
  • Serum Electrolytes: Measures important minerals like sodium, potassium, and chloride to check your body’s mineral balance.
  • eGFR: Estimates your overall kidney function based on creatinine level, age, sex, and body size.

FAQs related to Uric Acid, Serum

A Uric Acid, Serum test estimates the uric acid in a blood sample. Uric acid is a waste product in the body left after purine breakdown. High uric acid levels indicate gout and kidney stones. The test requires simple blood collection without any special preparation beforehand.
High uric acid leads to kidney stones and gout (a type of arthritis). It also increases the risk of diabetes, high blood pressure, and heart problems.
Hormonal changes decrease the serum uric acid level to 3 mg/dl or below in the early months of pregnancy. During the third month, these levels rise to 4-5 mg/dl. A uric acid level more than 6 mg/dl at 32 weeks of gestation is related to a high perinatal mortality rate.
The normal range of uric acid in blood is approximately 3.7–9.2 mg/dL for adult males and 3.1–7.8 mg/dL for adult females. This range may vary slightly by lab, depending upon methodology and age.​
Yes. Exercise can reduce uric acid naturally by enhancing its removal. However, intense exercise can dehydrate you, which can increase uric acid levels. Therefore, stay hydrated after exercise or opt for light exercises.
The fastest way to lower uric acid is to drink plenty of water and avoid foods and drinks that raise uric acid.
No. Sweating during sauna or exercise can dehydrate the body. It decreases the removal of uric acid, thereby increasing uric acid levels.
It is vital to consult a doctor if you have high uric acid during pregnancy. Take the required medications and regularly monitor your uric acid levels. Stay well-hydrated and do light exercises to keep uric acid levels within the normal range. Also, eat a balanced and healthy diet, low in purines and fructose.
No. Fasting is not required before the Uric Acid, Serum test. You can eat and drink normally. However, it is better to inform your doctor of any medications you are taking, as some medicines change uric acid levels.
Gout is a condition that results in swelling of joints that is painful, most commonly in the lower limbs and toes. It occurs when there is excess uric acid in the blood that causes uric acid crystals to deposit in the joints. Pseudogout shares symptoms but is due to calcium pyrophosphate crystals, primarily in the knees, and occasionally the ankles, elbows, or wrists. It is associated with conditions such as elevated calcium or iron levels, thyroid disease, magnesium deficiency, or aging.
No, fasting is not required for this test. You can eat and drink as per your daily routine.
Foods that increase uric acid contain purines or fructose. These include red meat, alcohol, seafood, corn syrup, and sweetened drinks.
Limit intake of purine- or fructose-rich foods or beverages. Exercise regularly, and stay hydrated. It will reduce uric acid naturally and also improve your overall health.
Limit intake of purine- or fructose-rich foods or beverages. Exercise regularly and stay hydrated. These small changes will keep your uric acid levels in the normal range and also improve your overall health.
The causes of an increase in uric acid include oxidative stress and inflammation that can harm the body. These processes also affect reproductive organs and thus lower the chances of pregnancy. Therefore, pregnant women or those planning pregnancy should regularly check their uric acid levels.
Walking is a light exercise that can surely lower the uric acid levels. It is also helpful for weight loss, joint health, and kidney health.
Yes. Stress can modify the cortisol levels in the body. High cortisol is associated with higher uric acid levels.
There is no best time to test uric acid. The test does not require fasting or any other preparation. Thus, a uric acid test can be conducted at any time.
Yes. Dehydration can increase the uric acid levels by slowing its removal from the body. Therefore, doctors advise drinking plenty of water to control uric acid levels.
Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.
The price for a Uric Acid, Serum test can vary depending on the location and the laboratory.
You can book Uric Acid, Serum at any Tata 1mg lab near you. Simply check for the nearest lab location and schedule a convenient date and time for your test.

Uric Acid, Serum test price for other cities

Price inKolkataRs. 139
Price inBangaloreRs. 179
Price inMumbaiRs. 179
Price inNew DelhiRs. 159
Price inHyderabadRs. 160

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Uric Acid, Serum