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SCL-70 Antibody, Serum

Also referred as

Autoimmune

For men & women

Earliest reports in

144 hours

Contains

1 test

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SCL-70 Antibody, Serum is a diagnostic test used to determine the presence of SCL-70 antibodies in the blood. SCL-70 antibodies are a diagnostic marker for scleroderma or systemic sclerosis, an autoimmune disorder.

An autoimmune disorder is a condition in which the immune system attacks its own body. Higher levels of SCL-70 antibody in the blood may indicate that a patient has scleroderma. However, the doctor may recommend additional tests like the antinuclear antibody test for confirmation.

Currently, there is no cure for scleroderma. Depending upon the symptoms, the doctor may initiate drug therapy to reduce symptoms and slow disease progression. Some lifestyle changes like avoiding smoking, being physically active, and avoiding foods that cause heartburn can be followed to remain healthy with scleroderma.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

Samples required

Blood

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What does SCL-70 Antibody, Serum measure?

The SCL-70 Antibody, Serum test detects the presence of antibodies against the topoisomerase I enzyme, which plays a role in DNA replication and repair. The presence of these antibodies are associated with systemic sclerosis (SSc), also known as scleroderma. The test can help diagnose SSc, predict the risk of complications, and differentiate SSc from other similar autoimmune conditions. A positive test result suggests that the immune system may be attacking this enzyme, which can lead to tissue damage and fibrosis. A negative result typically means that these antibodies are not present, making systemic sclerosis less likely, though it doesn’t completely rule it out. Additional tests may be needed to confirm a diagnosis or explore other possible autoimmune conditions.

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Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

8th Nov 2025