MMR Panel (MLH1, MSH2,MSH6 & PMS2) near me in Indore
Also referred as
Colorectal and endometrial cancer markers
For men & women
Earliest reports in
7 days
Contains
4 tests
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The MMR Panel (MLH1, MSH2,MSH6 & PMS2) checks for the presence of key DNA repair proteins in tumor tissue. It helps identify abnormalities in the mismatch repair (MMR) system that may be linked to certain cancers, including colorectal and endometrial cancer. This immunohistochemistry (IHC) based test evaluates four critical MMR proteins: MLH1, MSH2, MSH6, and PMS2. When one or more proteins are absent, it indicates a defect in the MMR pathway, which may contribute to tumor development. Detecting MMR deficiency helps doctors identify at-risk tumors, screen for Lynch syndrome, and guide treatment planning, including potential immunotherapy options. This test is widely available with Tata 1mg labs at an affordable price in Indore.
Samples required
Tissue Block : FFPE ( Formalin-Fixed & Paraffin-Embedded)
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Test Information is reviewed by: Dr. Swati Gupta (Anand), MD Lab Medicine, MBBS and written by Shweta Prakash, MSc, BSc . The test details are for information purpose only. Consult a doctor before taking any test. Last updated on: 30th Oct 2026
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References
- Friker LL, Perwein T, Waha A, Dörner E, Klein R, Blattner-Johnson M, Layer JP, Sturm D, Nussbaumer G, Kwiecien R, Spier I, Aretz S, Kerl K, Hennewig U, Rohde M, Karow A, Bluemcke I, Schmitz AK, Reinhard H, Hernáiz Driever P, Wendt S, Weiser A, Guerreiro Stücklin AS, Gerber NU, von Bueren AO, Khurana C, Jorch N, Wiese M, Kratz CP, Eyrich M, Karremann M, Herrlinger U, Hölzel M, Jones DTW, Hoffmann M, Pietsch T, Gielen GH, Kramm CM. MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma. Acta Neuropathol. 2025 Feb 2;149(1):11. [Accessed 06 Nov. 2025]. Available From:
- Salem ME, Bodor JN, Puccini A, Xiu J, Goldberg RM, Grothey A, Korn WM, Shields AF, Worrilow WM, Kim ES, Lenz HJ, Marshall JL, Hall MJ. Relationship between MLH1, PMS2, MSH2 and MSH6 gene-specific alterations and tumor mutational burden in 1057 microsatellite instability-high solid tumors. Int J Cancer. 2020 Nov 15;147(10):2948-2956. [Accessed 06 Nov. 2025]. Available From:
Contains 4 tests
Samples required
Preparations
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