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Lupus Anticoagulant (LAC) Profile

Also referred as

Lupus Inhibitor Profile

LA Profile

LAC

For men & women

Earliest reports in

48 hours

Contains

3 tests

Know more about this test

The Lupus Anticoagulant (LAC) Profile is a group of blood tests that helps evaluate the risk of abnormal blood clotting due to the presence of lupus anticoagulant antibodies. It includes dilute Russell viper venom time (DRVVT) screen, activated partial thromboplastin time (APTT), and lupus anticoagulant tests to assess clotting times and detect autoimmune activity.

Samples required

Blood

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Why is this test booked?

Preparations

Overnight fasting required for 8 to 12 hours

Sample Collection

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Understanding Lupus Anticoagulant (LAC) Profile

The lupus anticoagulant (LAC) profile is a group of blood tests used to detect lupus anticoagulant antibodies, which are abnormal immune proteins that interfere with the body’s natural clotting process. These antibodies do not cause bleeding; instead, they increase the risk of abnormal blood clots (thrombosis) in veins and arteries. This test helps diagnose antiphospholipid syndrome (APS), a serious autoimmune condition linked to complications like deep vein thrombosis (DVT), stroke, repeated miscarriages, and pregnancy-related issues.

Doctors may recommend this profile if symptoms include unexplained blood clots, frequent miscarriages, stroke at a young age, or prolonged clotting time on routine lab tests. It is also advised in cases of autoimmune diseases like lupus, or during evaluation for clotting disorders, before surgery, or during pregnancy.

The profile includes three main tests: dilute Russell viper venom time (DRVVT) to screen for clotting delays, activated partial thromboplastin time (APTT) to measure how long blood takes to clot, and the lupus anticoagulant confirmatory test to detect these specific antibodies.

An overnight fast is preferred but not mandatory for the Lupus Anticoagulant (LAC) Profile. A duly filled coagulation requisition form (Annexure - CR/05) is mandatory for sample collection. Kindly provide complete clinical details and medication history or a doctor's prescription. This information is important for the correlation of the test results. Inform the doctor about all medications (e.g., blood thinners, anticoagulant medications) and supplements currently being taken, as some of them may affect the test results, potentially requiring dosage adjustments or temporary discontinuation before the test.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly. This test provides vital information that can guide timely treatment and help prevent future clotting complications.

Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.

What does Lupus Anticoagulant (LAC) Profile measure?

Contains 3 tests

The Lupus Anticoagulant (LAC) Profile is a group of blood tests that help measure how lupus anticoagulant antibodies affect blood clotting. These tests include:

1. Dilute Russell viper venom time (DRVVT) – Screen:

Measures clotting time. Prolonged clotting time suggests the presence of lupus anticoagulant.

2. Activated Partial Thromboplastin Time (APTT):

Assesses the intrinsic clotting pathway. If prolonged, it may indicate inhibitors like lupus anticoagulant.

3. Lupus Anticoagulant Test:

Confirms the presence of lupus anticoagulants (antibodies that target phospholipids and interfere with normal clotting mechanisms).

DRVV Screen

Activated Partial Thromboplastin Time

An Activated Partial Thromboplastin Time test measures the time taken by the blood to form a clot. In other words, it is a screening test that helps evaluate a person’s ability to form blood clots. The test analyzes the amount and the function of specific proteins in the blood called coagulation or clotting factors, which are an essential part of blood clot formation.

Blood clotting or coagulation occurs through a series of cascade reactions due to the activation of clotting factors. There are a total of thirteen clotting factors within our bodies that aid in clot formation, and for healthy clot formation, all clotting factors need to be in the right balance. Any imbalance of these factors can lead to a blood clotting disorder.

Know more about Activated Partial Thromboplastin Time

Lupus Anticoagulant

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FAQs related to Lupus Anticoagulant (LAC) Profile

What is the Lupus Anticoagulant (LAC) Profile?

The Lupus Anticoagulant (LAC) Profile is a group of three blood tests that help detect lupus anticoagulant antibodies that increase the risk of blood clots.

When is the Lupus Anticoagulant (LAC) Profile recommended?

A doctor may recommend the Lupus Anticoagulant (LAC) Profile if any of the following apply: • An unexplained history of recurrent miscarriages or fetal loss. • Symptoms suggestive of abnormal blood clotting, such as deep vein thrombosis or pulmonary embolism. • A family history of abnormal blood-clotting disorders. • A prolonged APTT test result. • Autoimmune diseases like systemic lupus erythematosus (SLE).

Do I need to fast before the Lupus Anticoagulant (LAC) Profile?

Fasting is preferred for this test, but it is not mandatory.

What do abnormal results mean?

Abnormal results may indicate the presence of lupus anticoagulant antibodies and an increased risk of blood clotting disorders.

How is the Lupus Anticoagulant (LAC) Profile done?

During the Lupus Anticoagulant (LAC) Profile, a blood sample will be collected from a vein in your arm, and it will be sent to the laboratory for testing.

Why is the Lupus Anticoagulant (LAC) Profile important during pregnancy?

Lupus anticoagulants can lead to complications such as recurrent miscarriages or preeclampsia. Detecting them helps manage pregnancy risks.

Can I take the Lupus Anticoagulant (LAC) Profile while on anticoagulants?

Blood thinners may interfere with test results. Your doctor may adjust or temporarily stop some medications before this test.

What other tests can be done alongside the Lupus Anticoagulant (LAC) Profile?

Doctors may suggest additional tests along with the Lupus Anticoagulant (LAC) Profile to better understand abnormal clotting. These can include: - Activated partial thromboplastin time (APTT), which checks specific clotting factors. - Prothrombin time/international normalized ratio (PT/INR), used to measure how quickly blood clots and monitor blood-thinning treatments. - A thrombophilia panel (tests for inherited or acquired clotting tendencies). In some cases, mixing studies may also be done to determine whether prolonged clotting times are due to a deficiency in clotting factors or the presence of an inhibitor such as lupus anticoagulant.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MD Lab Medicine, MBBS

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Last Updated

19th Dec 2025