How can we help?

Home

Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA

Also referred as

Antineutrophil Cytoplasmic Antibodies (ANCA) Test

136+ booked recently

For men & women

Earliest reports in

48 hours

Contains

3 tests

Know more about this test

The Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA is a blood test that detects antibodies attacking cytoplasmic proteins in neutrophils (white blood cells). These antibodies are linked to a disease called vasculitis, which causes swollen blood vessels. It helps doctors identify the type of vasculitis and guide treatment accordingly.

Samples required

Blood

Find out

Why is this test booked?

Preparations

No special preparation is required.

Sample Collection

Who will collect your samples?

Understanding Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA

Anti-neutrophil cytoplasmic antibodies (ANCA) are antibodies that the body’s immune system makes by mistake. They target neutrophils, a type of white blood cell. In conditions like vasculitis, ANCA causes these neutrophils to attack the blood vessels, leading to inflammation and damage. This can affect important organs like the kidneys, lungs, and sinuses, causing serious symptoms.

The Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test is a group of blood tests. It is tailored to detect specific ANCA antibodies in the blood. It looks for three main types of ANCA: MPO (p-ANCA), PR3 (c-ANCA), and atypical ANCA. These markers are crucial in identifying different forms of ANCA-associated vasculitis (AAV), such as granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).

The Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test is done when a doctor suspects autoimmune vasculitis symptoms such as persistent fever, weight loss, fatigue, joint pain, skin rash, or unexplained inflammation. It may also be done if someone has a family history of autoimmune diseases. It is also beneficial for someone who already has autoimmune conditions, such as inflammatory bowel disease.

A positive result means that ANCA antibodies are present in the blood. This suggests the possibility of vasculitis. The specific type of ANCA found helps identify the type of vasculitis, guiding treatment. A negative result generally indicates that ANCA-associated vasculitis is unlikely. However, it doesn't completely rule out the condition, as some forms of vasculitis may not involve ANCA antibodies. Additional testing is recommended to establish a comprehensive diagnosis following discussion with your clinician.

Usually, no special preparation such as fasting or dietary restriction is needed for this test. Inform the doctor about all the medicines and supplements being taken, as some of them may affect the test results.

Test result ranges may vary across laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results. Always consult a doctor for a proper understanding of the test results.

What does Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA measure?

Contains 3 tests

The Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA checks for ANCA antibodies which are important for diagnosing and managing autoimmune vasculitis. It identifies different types of vasculitis by measuring three main ANCA antibodies: MPO (p-ANCA), PR3 (c-ANCA), and atypical ANCA. MPO (p-ANCA) is linked to conditions like microscopic polyangiitis (MPA). PR3 (c-ANCA) is connected to granulomatosis with polyangiitis (GPA). Lastly, atypical ANCA is found in conditions like inflammatory bowel disease and autoimmune hepatitis.

MPO (p-ANCA)

The MPO (p-ANCA) test detects antibodies in the blood that target myeloperoxidase (MPO), a protein found in certain white blood cells. These antibodies are commonly associated with autoimmune diseases like Microscopic Polyangiitis (MPA) and Churg-Strauss Syndrome, which cause inflammation in small blood vessels. A positive MPO (p-ANCA) test helps doctors diagnose these conditions, differentiate them from other similar health issues, and guide appropriate treatment for better management.

Know more about MPO (p-ANCA)

PR3 (c-ANCA)

The PR3 (c-ANCA) test detects antibodies in the blood that target proteinase-3 (PR3), a protein found in certain white blood cells. These antibodies are commonly associated with autoimmune diseases like Granulomatosis with Polyangiitis (GPA), which causes inflammation in blood vessels and affects organs such as the kidneys, lungs, and sinuses. A positive PR3 (c-ANCA) test helps doctors diagnose these conditions, distinguish them from other similar health issues, and guide the appropriate treatment for better disease management.

Know more about PR3 (c-ANCA)

Atypical ANCA

The Atypical ANCA (Anti-Neutrophil Cytoplasmic Antibodies) test measures the presence of specific antibodies in the blood that target proteins in neutrophils, a type of white blood cell. These antibodies are often linked to autoimmune conditions such as Churg-Strauss Syndrome, Ulcerative Colitis, autoimmune hepatitis and certain types of vasculitis. Unlike the typical ANCA test, which detects antibodies against proteins like proteinase 3 (PR3) and myeloperoxidase (MPO), the atypical ANCA test looks for antibodies against other antigens. This test is primarily used in diagnosing autoimmune conditions like vasculitis, particularly those that may not show up with other ANCA testing, helping doctors identify and manage these conditions more accurately.

Know more about Atypical ANCA

Frequently booked together

FAQs related to Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA

What is the Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test?

The Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA is a blood test that looks for special antibodies called ANCA. These antibodies can show up when the immune system attacks the blood vessels by mistake, a condition called autoimmune vasculitis. This leads to inflammation and organ damage.

Why is the Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test performed?

Doctors use this test to find out if someone has ANCA-associated vasculitis (AAV). It also helps them see how serious the condition is, track how it's changing over time, and decide on the best treatment.

Do I need to fast before the test?

No fasting is required for this test. You can schedule it at your convenience without avoiding food or water beforehand.

How is the Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test performed?

A blood sample is collected, and the test uses an Indirect Immunofluorescence Assay (IFA) to detect and measure the levels of ANCA antibodies in the blood.

What does a positive result mean?

A positive result indicates the presence of ANCA antibodies. It suggests that vasculitis may be present. The specific type of ANCA (e.g., MPO or PR3) can help identify the type of vasculitis and guide treatment.

What does a negative result mean?

A negative result generally means that ANCA-associated vasculitis is unlikely. However, it does not completely rule out the condition, as some forms of vasculitis may not involve ANCA antibodies.

Is the Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test required for everyone with symptoms of vasculitis?

Not necessarily. The test is usually recommended if symptoms suggest vasculitis or if there are risk factors, like a family history of autoimmune diseases or other autoimmune conditions.

What is autoimmune vasculitis?

Autoimmune vasculitis is a group of conditions where the immune system attacks blood vessels by mistake, causing swelling. This can harm organs like the kidneys, lungs, and sinuses. It can range from mild to severe, so early diagnosis is important for treatment.

How are autoimmune vasculitis and ANCA related?

What types of autoimmune vasculitis does the Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test detect?

The Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA test helps find vasculitis linked to ANCA, including conditions like granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). These are known as ANCA-associated vasculitis (AAV).

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories. Tata mg uses advanced technology and adheres to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

MD Microbiology, MBBS

Want to know moreRead our editorial policy

Last Updated

9th Oct 2025