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Anti-CCP Antibody

Also referred as

Cyclic citrullinated peptide antibody

Anti-citrullinated peptide antibody

Citrulline antibody

Anti-cyclic citrullinated peptide

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The Anti-CCP Antibody test helps diagnose rheumatoid arthritis (RA) and tells it apart from other types of arthritis. It looks for anti-cyclic citrullinated peptide (Anti-CCP) antibodies in your blood. These antibodies are linked to autoimmune diseases like RA and are often present in the early stages.

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Understanding Anti-CCP Antibody

Rheumatoid arthritis (RA) is an autoimmune (a condition in which the body's natural defense system mistakenly attacks normal/healthy cells) and an inflammatory condition that causes inflammation (painful swelling) of the joints. In addition to the joints, RA sometimes also affects other body parts, including skin, eyes, lungs, or heart.

The Anti-CCP Antibody test checks for the presence and level of Anti-CCP antibodies in your blood. These antibodies are produced by your immune system in response to certain proteins found in the joints in individuals with RA. These antibodies are specific to RA and their presence can be detected even before the symptoms start.

Studies suggets that more than 75% of people with RA test positive for Anti-CCP antibodies. This test helps doctors identify RA early and distinguish it from similar conditions like psoriatic arthritis or juvenile idiopathic arthritis. This test is more specific than other tests like the Rheumatoid Factor (RF) test.

Doctors may suggest this test if you have joint pain, swelling, warmth, morning stiffness, or lumps under the skin. A positive result means these antibodies are in your blood, which makes RA more likely. A negative result does not rule out RA but may mean there’s a lower chance.

No special preparation is needed. You can eat and drink normally. Results may vary based on your age, gender, health, and other factors. Share your full medical history with your doctor to help them better understand your condition and make a suitable treatment plan, including diet, exercise, or medicines.

What does Anti-CCP Antibody measure?

The Anti-CCP Antibody test measures antibodies against cyclic citrullinated peptides (CCP) in the blood. These antibodies are called Anti-CCP antibodies. In rheumatoid arthritis (RA), the body changes a protein building block called arginine into citrulline. The immune system may see these as threats and make antibodies against them. Anti-CCP antibodies are early markers of RA. They can cause long-term joint inflammation and damage. Their presence helps detect RA early, understand how it may progress, and plan proper treatment.

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FAQs related to Anti-CCP Antibody

Why is the Anti-CCP Antibody test done?

This test is done to diagnose rheumatoid arthritis, check its severity, and see how it may progress. It also helps to tell RA apart from other similar conditions.

Is fasting needed for the Anti-CCP Antibody test?

No, fasting is not needed. But let your doctor know about any medicines or supplements you take, as some can affect the result.

What causes high CCP antibodies?

The exact reason for high CCP is unknown, but genetics, smoking, obesity, and age may raise the levels.

What does a positive anti-CCP test result mean?

It means you have antibodies linked to RA. A positive result increases the chance of RA but doesn't confirm it alone. Your doctor may perform more tests to be sure.

What other tests can be advised for the diagnosis of rheumatoid arthritis?

Apart from an anti-CCP antibody test, a Rheumatoid Factor-Quantitative test, a Joint X-rays, and a few other blood tests may be advised.

What factors can affect the levels of anti-CCP antibodies?

The primary factor affecting the levels of anti-CCP antibodies is the presence of rheumatoid arthritis. However, other factors, such as certain medications, other inflammatory conditions, and genetics, can also affect these levels.

What is rheumatoid arthritis?

Rheumatoid arthritis is an autoimmune condition that causes chronic joint pain, stiffness, and swelling. It can start at any age but is more common after 40, especially in women. If left untreated, it can lead to joint damage and disability.

Is rheumatoid arthritis curable?

RA cannot be completely cured, but its symptoms can be controlled with treatment. Proper care can slow down the disease and improve quality of life.

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Last Updated

9th Oct 2025