Affiliates - Triple H (HIV, HBV, HCV)

An HIV Combo (Antigen And Antibody) Test simultaneously detects HIV p24 antigen and antibodies associated with HIV 1 & 2. The HIV p24 antigen is the most abundant HIV protein. Its detection is used clinically to diagnose an HIV infection early on since HIV-specific antibodies are not detectable in a very recently acquired infection.

HIV-1 was discovered first and is the most widespread. HIV-2 is more than 55% genetically different from HIV-1. The transmission rate of HIV-2 is also slower than HIV-1. 

The Hepatitis C Virus (HCV) Antibody test determines the status of current hepatitis C virus (HCV) infection or past HCV infection that has been resolved. This test, therefore, helps your doctor to guide an appropriate treatment plan. HCV causes liver inflammation and is classified into acute hepatitis infection and chronic hepatitis infection.

• Acute hepatitis C: This occurs in the first six months after exposure to the hepatitis C virus. In the early stage of the infection, acute hepatitis C is mild and may cause no symptoms. For this reason, most people do not know they have this infection.
• Chronic hepatitis C: If your body is unable to fight off the virus, you can develop a chronic hepatitis C infection. Progression from acute to chronic hepatitis C is common, occurring in about 75-85% of patients. Detecting chronic hepatitis C at the early stage is important to prevent future complications, such as liver failure, and initiate effective treatment.

The Hepatitis C Virus (HCV) Antibody test is used for screening for anti-HCV antibodies. A reactive result needs to be confirmed by other more specific NAT/ nucleic acid tests before final diagnosis.

The Hepatitis B Surface Antigen (HBsAg) test detects HBsAg, a protein on the surface of the hepatitis B virus (HBV), in the blood. It is an important screening test for HBV infection. A reactive result needs follow-up with additional tests, such as anti-HBs and total anti-HBc antibodies, and can be confirmed with HBV DNA testing by PCR. This test helps identify individuals who may need medical treatment and supports measures to prevent the spread of hepatitis B. The test uses automated chemiluminescence immunoassay (CMIA/CLIA) technology, which may vary slightly across laboratories.

What Do the Results Mean?

Pathological Factors

Physiological Factors
 🧒 Age: Newborns and infants may have maternal HBsAg in their blood, which can affect test results.

🫄 Pregnancy: Changes in immunity and liver function during pregnancy may slightly affect HBsAg detection.

⏳ Infection Stage: Very early infection (window period) or late/chronic stages may change HBsAg levels.

Lifestyle Factors

🥗 Alcohol: Heavy drinking can affect liver function, which may indirectly influence test results.

💊 Medications: Antivirals or immunosuppressive drugs can lower viral levels, potentially altering HBsAg readings.

💉 Recent Vaccination: Hepatitis B vaccination may affect antibody levels but usually does not impact HBsAg detection.

Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.

What Do Negative Hepatitis B Surface Antigen (HBsAg) Results Mean?

A negative result usually means you do not have an active hepatitis B infection at the time of the test. It does not rule out a past infection or very early-stage infection.

What Do Positive Hepatitis B Surface Antigen (HBsAg) Results Mean?

A positive result means the hepatitis B virus is present in your blood. Early detection enables timely treatment, monitoring, and measures to prevent the spread to others.

What to Do if Your Hepatitis B Surface Antigen (HBsAg) Result Is Positive?

• Consult your doctor for further evaluation and treatment
• Inform close contacts so they can get vaccinated or tested
• Follow your doctor’s schedule for liver check-ups and viral load monitoring
• Avoid sharing personal items like razors or toothbrushes

Can Hepatitis B Surface Antigen (HBsAg) Results Be Inaccurate?

Though the test is reliable, certain factors may lead to false-positive or false-negative results:

• Low viral load (in the early stage
• Improper sample collection or handling
• Interference from recent vaccination or medical conditions