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Chromogranin A
Overview
What is Chromogranin A?
Chromogranin A is a protein released by neuroendocrine cells into the blood in a moderate amount. Its measurement is used for the detection of a neuroendocrine tumor. This protein is released by neuroendocrine cells into the blood in a moderate amount. An elevated amount of chromogranin A above normal level in the blood is an indication of a neuroendocrine tumor. This test is recommended by a physician if he suspects any symptoms of neuroendocrine tumor such as flushing of the face or neck, diarrhea, signs of intestinal blockage, rapid heart rate, chest pain and difficulty in breathing. A normal range of chromogranin is > 93ng/mL.
This test aids in the diagnosis of medical conditions including carcinoid tumors, insulinomas, medullary thyroid carcinomas, pheochromocytoma, neuroblastoma, small cell lung cancer and prostate cancer. It is also useful in monitoring the efficacy of a neuroendocrine tumor treatment and reccurence of the tumor.
Sometimes hepatic failure may lead to minor elevation in chromogranin A level while renal impairment can lead to very high level of chromogranin A.
Why is Chromogranin A done?
- Chromogranin A is the first line test for diagnosing Carcinoid tumors
- For diagnosis of neuroendocrine tumors
- To assess disease progression
- To evaluate response to therapy
- To detect recurrence after surgical resection
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