
Quadruple Marker with Graph - 2nd Trimester near me in Coimbatore










A Quadruple Marker with Graph - 2nd Trimester is a prenatal screening test typically conducted between the 14th and 22nd weeks (ideal 15-20 weeks, i.e., second trimester) of pregnancy. It tells about the risk of specific chromosomal abnormalities, such as Down syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18), neural tube defects (such as spina bifida), and anencephaly (a brain defect) in the fetus. It is widely available with Tata 1mg labs at an affordable price in Coimbatore.
This test measures the levels of four specific biomarkers in the mother’s blood: Alpha-fetoprotein (AFP), Human Chorionic Gonadotropin (hCG), Estriol unconjugated (uE3), and Inhibin A. The levels of these markers, when assessed collectively along with maternal age, gestational age, and ultrasound findings, help determine the likelihood of certain fetal abnormalities that can affect the baby’s growth and development.
In addition to the traditional Quad marker analysis, the inclusion of a graphical representation enhances the interpretability of results.
No special preparation is required before undergoing a Quadruple Marker with Graph - 2nd Trimester test. However, a woman needs to provide informed consent before undertaking this test. The laboratory personnel will explain the purpose, benefits, and limitations of this test.








What does Quadruple Marker with Graph - 2nd Trimester measure?
Contains 4 testsA Quadruple Marker with Graph - 2nd Trimester test measures the levels of four specific markers in a pregnant woman's blood. These markers are -Alpha-Fetoprotein (AFP), Human Chorionic Gonadotropin (hCG), Estriol Unconjugated , and Inhibin-A.
The analysis of these four markers and other factors like maternal age and gestational age helps assess the risk of certain conditions in the developing baby. The graph in a Quadruple Marker with Graph - 2nd Trimester provides a visual representation of the levels of these markers during pregnancy.
It is noteworthy that a Quadruple Marker with Graph - 2nd Trimester is a screening test, and any abnormal results may prompt further diagnostic testing for confirmation. Pregnant women should discuss their results and implications with their doctor.
The Inhibin A test measures the level of inhibin A in the blood. It is a hormone primarily produced by the ovaries in women. It plays a key role in regulating menstrual cycle and ovarian function by inhibiting the production of follicle-stimulating hormone (FSH). During pregnancy, elevated levels of Inhibin A may point towards a risk of certain chromosomal abnormalities like Down’s syndrome etc., in the fetus.
The Inhibin A test is particularly useful in assessing ovarian function, fertility assessment, prenatal screening and diagnosing certain ovarian cancers.
Know more about Inhibin A
The HCG Beta Total Quantitative, Maternal test measures the levels of human chorionic gonadotropin (hCG) hormone in the blood. hCG is released in the blood during pregnancy and can be detected as early as 10 to 12 days after conception. The levels of this hormone gradually rise every 2 to 3 days (or 48 to 72 hours) and peak around 8 to 11 weeks after conception. After reaching the peak, the hCG levels decrease and remain steady for the rest of the pregnancy.
Know more about HCG Beta Total Quantitative, Maternal
An Alpha Feto Protein, Maternal test measures the amount of Alpha Fetoprotein in expectant mothers usually during the second trimester (14th and 22nd weeks). AFP is a protein produced by the fetus, primarily by the fetal liver and yolk sac, and it passes into the mother's blood. The test is typically performed to screen for certain fetal abnormalities, particularly neural tube defects (NTDs) such as spina bifida and anencephaly, as well as chromosomal abnormalities like Down syndrome (trisomy 21), Edwards syndrome (Trisomy 18), etc.
Detecting these abnormalities early in pregnancy allows for appropriate medical management and intervention.
Know more about Alpha Feto Protein, Maternal
The Estriol Unconjugated test is used to assess the level of unconjugated estriol (uE3) in the blood, a specific type of estrogen produced during the pregnancy phase. This hormone is mainly synthesized in the placenta and the fetus, with the fetus being responsible for a substantial amount of uE3 production as it grows.
Monitoring the uE3 levels in the maternal serum is useful in evaluating the condition of the fetus. Abnormal unconjugated estriol levels may indicate pregnancy-related complications or concerns, including chromosomal abnormalities, fetal distress, or placental problems. The Estriol Unconjugated is particularly crucial in the second trimester to assess for some conditions, such as Down syndrome, Edward syndrome, or other chromosomal abnormalities, fetal growth and development. Hence the estriol unconjugated test is a significant part of prenatal care as it reveals information that may be valuable for the diagnosis and management of the mother and the baby.
Know more about Estriol Unconjugated





FAQs related to Quadruple Marker with Graph - 2nd Trimester in Coimbatore
- Greene ND, Copp AJ. Neural tube defects. Annu Rev Neurosci. 2014;37:221-42. [Accessed 20 Dec. 2023]. Available from:
- Screening for Down's syndrome, Edwards' syndrome and Patau's syndrome [Internet]. NHS; 19 April 2021 [Accessed 20 Dec. 2023]. Available from:
- Sablok A, Sharma A, Ahmed CS, Kaul A. Performance of second-trimester maternal biochemistry screening (quadruple test vs. triple test) for trisomy 21: An Indian experience. Indian J Med Res. 2021 May;154(5):716-722. [Accessed 20 Dec. 2023]. Available from:
- Gordon S, Umandap C, Langaker MD. Prenatal Genetic Screening. [Updated 2023 Jan 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
- Güdücü N, Görmüş U, Güner Eİ, Güzel O, Kavak ZN. Quadruple test parameters in art pregnancies. Int J Clin Exp Med. 2014 Aug 15;7(8):2319-23. PMID: 25232428; PMCID: PMC4161588. [Accessed 20 Dec. 2023]. Available from:
- Commit to Healthy Choices to Help Prevent Birth Defects [Internet]. CDC; 28 June 2023 [Accessed 20 Dec. 2023]. Available from:
- Institute of Medicine (US) Committee on Improving Birth Outcomes; Bale JR, Stoll BJ, Lucas AO, editors. Reducing Birth Defects: Meeting the Challenge in the Developing World. Washington (DC): National Academies Press (US); 2003. 3, Interventions to Reduce the Impact of Birth Defects. [Accessed 20 Dec. 2023]. Available from:
- Boonpiam R, Wanapirak C, Sirichotiyakul S, Sekararithi R, Traisrisilp K, Tongsong T. Quad test for fetal aneuploidy screening as a predictor of small-for-gestational age fetuses: a population-based study. BMC Pregnancy Childbirth. 2020 Oct 15;20(1):621. [Accessed 20 Dec. 2023]. Available from:
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