Hepatitis B Virus - Viral Load, Quantitative
What is HBV Quant.?
The Hepatitis B Virus - Viral Load, Quantitative test is advised in case of signs and symptoms of acute hepatitis such as loss of appetite, jaundice, nausea, vomiting, and abdominal pain.
Why is HBV Quant. done?
The Hepatitis B Virus - Viral Load, Quantitative test is done:
For the management of patients with chronic hepatitis B infection and currently on antiviral therapy
For the diagnosis of hepatitis B for baseline values and during the course of therapy to assess the response of treatment.
What does HBV Quant. Measure?
The Hepatitis B Virus - Viral Load, Quantitative test measures the actual amount of hepatitis B present in a blood sample. This test helps determine whether Hepatitis B Virus (HBV) is getting reproduced in the liver. If HBV viral load is greater than 20,000 international units per milliliter (IU/mL) in a person with detectable Hepatitis B envelope antigen (HBeAg) then it indicates that the virus is active and has the greatest potential to cause damage to the liver. Similarly, if HBV viral load is greater than 2,000 IU/mL in HBeAg-negative chronic hepatitis B patients then it indicates that the virus is active and has the potential to cause damage to the liver. If the HBV viral load is above these numbers, treatment is considered necessary.
Interpreting HBV Quant. results
RESULT in IU/mL
Target not detected
Sample provided does not contain HBV DNA
HBV DNA detected, but below the lower limit of linear range of the assay. These results should be interpreted with caution
>=20 to < 1.7 x 108
HBV DNA detected within the linear range of the assay
>=1.7 x 108
HBV DNA detected above the linear range of the assay
Linear reporting range of the assay is 20 - 1.7 x 108 IU/mL
Conversion factor: 1 IU/mL = 5.82 copies / mL
Results are categorized into 3 levels
Low or undetectable viral load means that the lab equipment cannot detect it and viral load is less than approximately 300 copies/mL
Moderate levels are about 10,000 – 90,000 copies/mL
High levels indicate quantities over 100,000 copies/mL, which is considered clinically significant