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Sucralfate Topical



Sucralfate is used to treat ulcers of the mouth, stomach and other parts of the gut. It may also be used to treat burn wounds, and ulcerative skin conditions including diaper rash.

How it works

Sucralfate belongs to the class of medications called as ulcer protectants. It interacts with proteins that are present on the ulcer surface to form an ulcer adherent layer, which is protective in nature. Gut ulcers are protected against various irritants including acid. On skin ulcers, sucralfate exerts bacteriostatic properties, in addition to ulcer protective activity.

Common side effects

Constipation, Difficulty in swalloing, Shortness of breath, Tongue swelling, Lip swelling, Skin rash, Throat swelling, Itching, Urticaria


Expert advice

  • Inform your doctor if you have kidney disease/ failure or are on dialysis.
  • Do not take acid reducing medications (ranitidine, famotidine, rabeprazole, omeprazole, pantoprazole etc.) for at least 2 hours after ingesting sucralfate.
  • Do not drive or use machinery if you feel dizzy or drowsy after ingesting sucralfate. 
  • Inform your doctor if symptoms of diaper rash do not disappear after applying the cream for 5 to 7 days.
  • Avoid direct contact of sucralfate topical with your eyes. In case of direct contact, wash your eyes with water immediately and seek immediate medical attention.
  • Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
  • Do not use if you are allergic to sucralfate or any of its ingredients.
  • Do not use if you have a history of atopic dermatitis (allergic condition characterized by dry skin, intense itching and red rash), fungal infection (candidiasis) or seborrheic dermatitis (greasy, yellow or red scaling on hairy areas of the body).

Frequently asked questions

Sucralfate Topical

Q. Is sucralfate an antibiotic/sulfa drug/pain-killer/PPI?
Sucralfate is not an antibiotic/sulfa drug/ PPI (proton-pump inhibitor) or a pain-killer. It is an ulcer protective medicine.
Q. Is sucralfate available or sold over the counter?
Yes, sucralfate is available over the counter.
Q. Is sucralfate gluten free?
Yes. Sucralfate is gluten free. However, please refer to package insert of the prescribed brand before use.
Q. Can I take sucralfate with Prilosec/Nexium/Tylenol/Zantac/ibuprofen/Pepto?
It is advisable to keep a gap of at least 2 hours when taking sucralfate with Prilosec/ Nexium/ Tylenol/ Zantac/ ibuprofen and Pepto.
Q. Does sucralfate cause headaches/weight gain/insomnia/heartburn?
Sucralfate does not cause headaches/weight gain/insomnia or heartburn. If you experience any such symptoms, please consult your doctor.

Is sucralfate a narcotic drug?
No. Sucralfate is not a narcotic drug.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)