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Simethicone is used to relieve painful pressure, hiccups, bloating and fullness caused by excess gas in the stomach and intestines in adults as well as in children.

How it works

Simethicone belongs to class of medications called surface active substances. It is an antifoaming agents and works by acting on inner lining of intestine and allowing gas bubbles to come together more easily helping to release trapped wind.

Common side effects

Allergic reaction


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Expert advice

Simethicone works best if you take it after meals and at bedtime. Call your doctor if the child's gas symptoms do not improve after treatment with simethicone. Do not allow the liquid form of this medicine to freeze. Do not take the medicine:
  • If you are allergic to it or to any other content in the medicine.
  • If you use mineral oil (paraffin oil) based laxatives.
Inform your doctor before taking this medicine:
  • If you have a thyroid disorder and are being treated for it.
  • If you are pregnant or planning to become pregnant or breast-feeding a baby.

Frequently asked questions


Q. Is simethicone antacid?
No. Simethicone is not an antacid. But it is used in preparations which are used as antacid.

Q. Does it contain aspirin?
It does not contain aspirin.
Q. Is simethicone available over the counter?
Yes. Simethicone is sold over the counter without a prescription.
Q. Is simethicone gluten free?
Yes. Simethicone is gluten free. However, please refer to package insert of the prescribed brand before use.
Q. Is simethicone safe?
Yes. Simethicone is relatively safe.

Q. Is it safe for babies?
 Safe for infants and babies, if used as recommended. In case of any side-effects, consult your doctor.
Q. Is it safe to take simethicone daily?
It is advisable to take simethicone only as per the instructions of the doctor.
Q. Is simethicone good for gas?
Yes. Simethicone is effective in the treatment of gas.

Q. Does it have any side effects?
 It does not have any known serious side-effects.
Q. Can I take simethicone with ibuprofen, famotidine, lansoprazole, omeprazole, antibiotics, ranitidine, ciprofloxacin, Pepto-bismol, or Depakote?
Yes. Simethicone can be taken with ibuprofen, famotidine, lansoprazole, omeprazole, antibiotics, ranitidine, ciprofloxacin, Pepto-bismol (bismuth subsalicylate) or Depakote (divalproate sodium), if prescribed by your doctor.
Q. Does simethicone cause nausea or constipation?
Simethicone is not known to cause nausea or constipation. If you experience any such symptoms, please consult your doctor.
Q. Is simethicone effective against acid reflux?
Simethicone is effective in controlling acid reflux if combined with an antacid.

Content on this page was last updated on 15 October, 2016, by Dr. Varun Gupta (MD Pharmacology)