Treatment Of Asthma
The common treatment approach for people with asthma involves use of preventive medicines (also known as controllers) and quick-relief medicines (also known as relievers)
A. Controllers
These medicines help reduce the swelling of the airways and prevent mucus formation. They are mostly used to prevent asthma attacks and protect the lungs. These medicine classes are:
1. Corticosteroids
These are the best and most commonly prescribed drugs for asthma. They act by inhibiting the activity of the inflammatory compounds such as prostaglandins, leukotrienes, and histamines which are responsible for inflammation. They are broadly classified into:
a) Inhaled corticosteroids (ICSs): ICSs are amongst the most effective anti-inflammatory medications available to treat asthma. Low-dose monotherapy of inhaled corticosteroids is usually given as first-line maintenance therapy for most children and adults dealing with asthma. Regular use of ICS have been shown to reduce symptoms and flare ups of asthma along with improvement in lung function. Example of drugs that belong to this category are:
b) Oral corticosteroids: These are generally given for the acute treatment of moderate to severe asthma. Prolonged use of oral steroids are generally avoided as it has been associated with potentially serious side effects. Examples include:
2. Leukotriene receptor antagonists
These medicines are effective for the treatment of asthma, are well tolerated and are safe to use. As the name suggests, they work by blocking the action of an inflammation-causing chemical messenger called leukotriene. These medicines thereby reduce the inflammation in the airways, preventing asthma and relieving symptoms of allergies. Common examples of these medicines include:
3. Biological therapies
Biological therapies such as the anti-IgE monoclonal antibody, example omalizumab, can reduce the frequency of asthma attacks. This drug is given subcutaneously once every 2–4 weeks. This medicine is specific to patients with difficult to control asthma with an elevated serum IgE level. It is also given to people whose asthma symptoms do not improve even with ICS therapy in combination with a second controller medication.
B. Relievers (bronchodilators)
These are the preferred medications for the treatment and maintenance of acute symptoms of asthma and are generally prescribed to all patients with asthma. They work by dilating the bronchioles, thereby providing only temporary relief. These medicines are used to relieve the symptoms of asthma when they occur but not reverse the inflammation that has already occured. Drugs that belong to the class of bronchodilators are:
1. Short-acting beta agonists (SABA)
These medicines are used for the treatment of asthma symptoms and its exacerbations. As the name suggests, these are known to provide quick relief. For example, salbutamol which is the common drug, has an action onset of under 5 minutes & lasts for 3 to 6 hours. Some of the common examples include:
2. Long- acting beta agonists (LABA)
This class of medicines contain low doses of controllers and relievers with a long lasting effect. These not only help you to relieve the symptoms but also protect you from asthma attacks. These medicines are often used in conjugation with other drugs such as corticosteroids. They have an action onset of more than 5 minutes but the effect lasts for at least 12 hours. Common example include:
3. Methylxanthines
These are a new class of medicines used for the treatment of asthma. It is known to aid in the treatment of asthma by reducing airways inflammation and airway obstruction which is seen in asthmatics. Theophylline is one of the most commonly prescribed methylxanthines.
4. Anticholinergic drugs
This class of medicines work by blocking the action of acetylcholine, a neurotransmitter which plays a key role in controlling the constriction of smooth muscles and inflammation. These are further classified into:
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Short acting muscarinic antagonists (SAMA): Ipratropium is the common medicine that belongs to this class. It is used to treat and prevent the symptoms of asthma and COPD along with improving the breathing.
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Long acting muscarinic antagonists (LAMA): Tiotropium is the common medicine which is mainly used for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
C. Other therapies
Bronchial thermoplasty is a bronchoscopic treatment using thermal energy to ablate airway smooth muscle in accessible bronchi. It may reduce exacerbations in patients not responding to maximal inhaler therapy.