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Apraclonidine (Lodipine)

INFORMATION

Uses

Apraclonidine (Lodipine) is used in the treatment of glaucoma (high eye pressure).

How it works

Apraclonidine belongs to a class of drugs called alpha agonists. The exact mechanism for its clinical effects is not clear, however, it is known to act on some naturally occurring substances in the eye muscles and reduce the formation of fluid (aqueous humor) in the eye, thereby lowering the intraocular pressure.

Common side effects

Pale colored skin, Pulling away of eye lid, Altered taste, Dry nose, Eye discomfort, Eye itching, Headache, Eye redness, Watery eyes, Weakness

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Expert advice

  • Episodes of sudden fainting (vasovagal attack) during laser eye surgeries should be monitored in patients with a history of such episodes.
  • You should be monitored for exaggerated reductions in fluid pressure inside the eye.
  • Apraclonidine should be used cautiously in patients with a history of chest pain (angina), severe coronary insufficiency (condition in which the heart is unable to pump blood sufficiently), recent heart attack (myocardial infarction), heart failure, diseases of blood circulation to the brain (cerebrovascular disease), long-term kidney failure (chronic renal failure), liver failure, disorders of blood vessels (Raynaud's disease or thromboangitis obliterans) or depression.
  • Frequent monitoring of heart rate and blood pressure is recommended in patients concomitantly receiving medications for heart problems (beta-blockers [eye drops or orally], antihypertensive, and cardiac glycosides [e.g. digitalis]) and patients undergoing eye surgeries.
  • Do not touch the tip of eye drop bottle to your fingers, eyes or surrounding areas to avoid contamination. Keep the bottle tightly closed when not in use.
  • Leave an interval of at least 5 min if you have to use another eye drop, after instilling apraclonidine eye drops.
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
  • Take precautions while driving or operating machinery as apraclonidine is known to cause dizziness and sleepiness (somnolence).

Frequently asked questions

Apraclonidine (Lodipine)

Q.What is apraclonidine ophthalmic solution?
Apraclonidine is used to control or prevent elevations in fluid pressure inside the eye (intraocular pressure) following laser eye surgery (anterior segment laser ophthalmic surgery)

Q.What is it used for?
It is also used as a short-term treatment to delay laser or surgical treatment for glaucoma (a condition characterized by increase in pressure inside the eye causing gradual loss of vision if left untreated) in patients not adequately controlled by similar medications. It is also useful in the diagnosis of Horner's syndrome

Q.How does apraclonidine work?
Apraclonidine belongs to a class of drugs called alpha agonists. The exact mechanism for its clinical effects is not clear, however, it is known to act on some naturally occurring substances in the eye muscles and reduce the formation of fluid (aqueous humor) in the eye, thereby lowering the intraocular pressure.


Content on this page was last updated on 15 October, 2016, by Dr. Varun Gupta (MD Pharmacology)