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MMST, MBBS
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MD (Pharmacology), MBBS
Last updated:
21 Feb 2020 | 12:19 PM (IST)
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Pegintroxyl 50mcg Injection


Overview

Introduction

Pegintroxyl 50mcg Injection is used in the treatment of chronic hepatitis C virus (HCV) infection.

Pegintroxyl 50mcg Injection is given as an injection by a qualified medical professional. You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your need and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Some common side effects of this medicine include headache, dizziness,  insomnia, vomiting, and nausea. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Hence, inform your doctor if you notice fever, chills, rash, trouble breathing, unusual bleeding or bruising, and dark colored urine. Regular blood tests are required to check your blood cells along with thyroid, liver, kidney and serum electrolytes levels.

Before taking it, tell your doctor if have liver, or kidney problems or have mental illness. You must inform your doctor about mental illness, mood changes, depression, vision change, and suicidal thoughts as this medicine can worsen the situation. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Pegintroxyl Injection

  • Chronic hepatitis C virus (HCV) infection

Side effects of Pegintroxyl Injection

Common
  • Abdominal pain
  • Agitation
  • Anxiety
  • Blurred vision
  • Cough
  • Decreased appetite
  • Decreased white blood cell count
  • Depression
  • Dizziness
  • Dryness in mouth
  • Fatigue
  • Headache
  • Impaired concentration
  • Indigestion
  • Insomnia (difficulty in sleeping)
  • Nausea
  • Nervousness
  • Sore throat
  • Stomatitis (Inflammation of the mouth)
  • Viral infection
  • Vomiting

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Abdominal pain
    In most cases, this is mild enough to be treated at home. Try to rest and relax. Putting a heat pad or covered hot water bottle on your stomach may also help. Having a warm bath or shower can help you relax and relieve the pain. Drink plenty of clear fluids such as water and reduce your intake of coffee, tea, lemon juice or soda. Avoid alcohol and smoking as these can aggravate the pain. Eating slowly and having smaller and more frequent meals can also help. If the pain is severe, speak to your doctor. They may be able to guide you better.
  • Coping with Agitation, Anxiety, and Nervousness
    This often disappears when the condition you are being treated for is managed. You could ask your doctor about changing the dose of your medicine or alternatives if it is affecting your daily life or causing you distress. Psychological treatments may be available. Some things you can do to help yourself include stopping smoking, cutting down the amount of alcohol and caffeine you drink, and doing regular exercise. You should also eat a healthy diet and find out how to get sleep if you are having trouble. Try talking to a friend or family member. Calming breathing exercises and other relaxation techniques may also help.
  • Coping with Blurred vision
    You can consider washing your eyes with water. Avoid driving or using tools or machines if your vision is impaired. Do not take your next dose if your vision is still blurry. If it gets worse or does not improve, ask your doctor to recommend eye drops or talk about changing your medications.
  • Coping with Cough
    Get plenty of rest as exhausting or stressing out yourself could aggravate your condition. You should drink plenty of fluids as it will keep your throat moist and comfortable. Try taking steam inhalation. The moisture can ease your breathing and loosen mucus. You can consider sipping warm water or tea with honey and lemon. This will keep your nose and throat from being too dry. Using an air humidifier may also help. You can also gargle with salt water several times a day. See your doctor if your symptoms last longer than 3 weeks or get worse quickly. Avoid alcohol and do not smoke as they can aggravate your conditions.
  • Coping with Decreased appetite
    It is important to eat, even if you do not feel like it. You might try switching to smaller meals and frequent snacks. Try eating healthy and nutritious snacks that are high in calories and protein, such as dried fruit and nuts. It is important to drink even if you cannot eat. But, do not fill your stomach with liquid before eating. Eat when you are most hungry. Exercise such as a short walk may also increase your appetite. Talk to your doctor about possible medication or supplements if your condition does not improve.
  • Coping with Decreased white blood cell count
    If you have a low level of white blood cells, you are more likely to get infections. There are several ways to reduce your chances of catching or spreading an infection. Avoid unnecessary exposure to germs when you can. Wash your hands frequently and thoroughly with soap or use a sanitiser. Avoid crowds and avoid contact with people who are ill or have infections. Use disposable tissues for coughs and sneezes. Consider using an appropriate face mask. Do not share personal items like cutlery, glasses, towels or toothbrushes with others. Get enough rest and eat a well balanced healthy diet.
  • Coping with Depression
    It is important to talk to your doctor if you think you may be depressed. The sooner you do this, the sooner you can recover. Treatment for depression can involve a combination of lifestyle changes, talking therapies (such as counseling and cognitive behavioral therapy) and medicines (antidepressants). There are many things you can do for yourself if your depression is not too severe. Exercise is an extremely effective treatment for depression, so make sure you keep as active as possible. It can really lift your mood. A healthy diet can also make a big difference to your mood (as well as improving your physical health). Mindfulness is a technique that many people find helpful. It may be tempting to smoke or drink alcohol, but both will make things worse in the long run. Try talking to a friend or family member even if you do not feel comfortable doing this. Get into a routine with regular sleep patterns and meals. If you have thoughts of self-harm or suicide, contact your doctor immediately.
  • Coping with Dizziness
    This is usually short-lived and should go away within a few days. If this happens, stop what you are doing and sit or lie down until you feel better. Lying still in a dark, quiet room may help reduce the spinning feeling. Sleep with your head slightly raised on two or more pillows. Get up slowly from a lying or sitting position. Get plenty of rest and try to relax as being anxious can make it worse. Try taking this medicine at bedtime to reduce the symptoms. Drinking plenty of water and ginger tea may also help. Avoid alcohol, caffeine and smoking as it will make you feel worse. Avoid driving or using tools or machinery until you feel better.
  • Coping with Dryness in mouth
    Keep a drink available that you can sip through the day. Rinse your mouth with warm salted water and chew sugarless gum or hard candy. Try breathing through your nose more often than your mouth. Avoid caffeinated beverages, smoking and alcohol because they can make your condition worse. Use lip balm if your lips are also dry. Try to avoid foods that are acidic (like lemons), spicy, salty or sugary. If this side effect bothers you or does not go away, talk to your doctor about artificial saliva products or other suitable treatments.
  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Impaired concentration
    If this medicine makes you feel this way, stop what you are doing and sit or lie down until you feel better. If the feeling does not go away or troubles you, do not take any more medicine and speak to a pharmacist or your doctor.
  • Coping with Indigestion
    Try taking your medicine with a meal or snack, or shortly after eating. It might help to eat smaller and more frequent meals, and to eat and drink slowly. Avoid foods which can irritate your stomach such as carbonated soft drinks, caffeine, fatty and spicy foods, mints and citrus fruits. Quit smoking and alcohol because they increase the symptoms. Do not eat for 3 or 4 hours before going to bed. Try raising the head of your bed at night or use extra pillows. Ask your doctor or pharmacist about medicines that may help, such as antacids, if your condition does not improve.
  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Sore throat
    Try gargling with warm salt water as it can help soothe a scratchy throat and relieve the discomfort. Stay hydrated by drinking plenty of water. Consider lozenges or hard candy. Avoid caffeine and alcohol, as they can dry out your throat and aggravate the symptoms. Also, avoid smoking or smoky places. Warm tea that is sweetened with honey can also soothe your irritated throat. Get plenty of rest and consider using a humidifier if the air in your home is dry. If it does not get better or get worse, talk to your doctor for advice.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.

How to use Pegintroxyl Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Pegintroxyl Injection works

Pegintroxyl 50mcg Injection modulates the body's immune system.

Safety Advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with Pegintroxyl 50mcg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Pegintroxyl 50mcg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Pegintroxyl 50mcg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
Pegintroxyl 50mcg Injection may cause side effects which could affect your ability to drive.
Patients may develop dizziness, confusion, somnolence, and fatigue while on Pegintroxyl 50mcg Injection and should be cautioned to avoid driving.
Kidney
UNSAFE
Pegintroxyl 50mcg Injection is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
Caution should be used in patients with renal impairment.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Pegintroxyl 50mcg Injection in patients with liver disease. Please consult your doctor.

What if you forget to take Pegintroxyl Injection?

If you miss a dose of Pegintroxyl 50mcg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Pegintroxyl 50mcg Injection
₹6421.0/ml of Injection
₹3609.09/ml of Injection
save 44%
₹5523.81/Injection
save 14%
Pegliton 50mcg Injection
Sun Pharmaceutical Industries Ltd
₹7114/Injection
11% costlier
₹9142.86/Injection
42% costlier
₹9268/ml of Injection
44% costlier

Quick Tips

  • Pegintroxyl 50mcg Injection helps treat chronic hepatitis C in adults.
  • Do not drive or do anything that requires mental focus until you know how it affects you.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and 4 months after stopping the treatment.
  • Your doctor may get regular blood tests done to monitor your blood cells, liver and thyroid function, and lipid levels during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
  • Inform your doctor if you notice any changes in your behavior, mood or vision.

Patient Concerns

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How to treatment of HEPATITIS C VIRUS
Dr. Deepak Kumar Soni
Ayurveda
https://www.1mg.com/otc/himalaya-liv.-52-ds-tablet-otc135545One ?one tablet morning & evening after taking food , use at least 1-2 monthsUse this medicine along with your treatment
I am affected from hepatitis c virus diagnosed with confirmed genotype. Meanwhile i am pregnant will hepatitis virus pass on my baby. Or i should abort
Dr. Kunal Parasar
Surgical Gastroenterology
Your reports are of february with no ongoin liver damage. You havnt got the quantitative analysis. Most probably you wont need to abort. But be in constant follow up of good gastroenterologist near you.
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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Peginterferon alfa-2b. Kenilworth, New Jersey: Schering Corporation; 2011. [Accessed 25 Jun. 2019] (online) Available from:External Link
  2. Medscape. Peginterferon alfa 2b. [Accessed 26 Jun. 2019] (online) Available from:External Link
  3. MedlinePlus. Peginterferon Alfa-2b. [Accessed 26 Jun. 2019] (online) Available from:External Link
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Peginterferon Alfa. [Updated 2018 Dec 3]. [Accessed 18 Feb. 2020] (online) Available from:External Link
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