Makrab O 4mg/20mg Tablet is a combinational medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to treat heartburn, acid reflux and problems in your food pipe.

Makrab O 4mg/20mg Tablet can be taken with or without food. How much you need, and how often you take it, will depend on what you are being treated for. Follow the advice of your doctor. You should keep taking it regularly to prevent problems from happening in the future. You may be able to help improve your symptoms by eating smaller meals more often and avoiding spicy or fatty foods.

Most people who take it do not have any side effects, but the most common include headache, constipation and diarrhea. If you do get a side effect, it is usually mild and will go away when you stop taking this medicine or as you adjust to it. Consult your doctor if any of these side effects bother you or do not go away.

Before taking it, you should tell your doctor if you have any kidney or liver problems. This may affect the dose or suitability of this medicine. Also, tell your doctor what other medicines you are taking as some may affect, or be affected by, this medicine. Avoid drinking alcohol as this can increase the amount of acid in your stomach and make your symptoms worse. If you are pregnant or breastfeeding, ask advice from your doctor.

Uses of Makrab O Tablet

Nausea
Vomiting
Gastroesophageal reflux disease (Acid reflux)
Peptic ulcer disease

Benefits of Makrab O Tablet

In Nausea

Makrab O 4mg/20mg Tablet blocks the action of chemicals in the body that can make you feel or be sick. This medicine helps you feel better and at ease. It is given as an injection by a doctor and you should follow the doctor’s instructions carefully to get the most benefit from this medicine.

In Gastroesophageal reflux disease (Acid reflux)

Gastroesophageal reflux disease (GERD) is a chronic (long-term) condition which is like having heartburn consistently rather than just occasionally. It happens because a muscle above your stomach relaxes too much and allows stomach contents to come back up into your esophagus and mouth. Makrab O 4mg/20mg Tablet reduces the amount of acid your stomach makes and relieves the pain associated with heartburn and acid reflux. You should take it exactly as it is prescribed for it to be effective.

Some simple lifestyle changes can help reduce the symptoms of GERD. Think about what foods trigger heartburn and try to avoid them; eat smaller, more frequent meals; try to lose weight if you are overweight and try to find ways to relax. Do not eat within 3-4 hours of going to bed.

In Peptic ulcer disease

Peptic ulcer disease is a condition in which painful sores or ulcers develop in the inner lining of the stomach or gut (intestine). Makrab O 4mg/20mg Tablet reduces the amount of acid your stomach makes which prevents further damage to the ulcer as it heals naturally. You may be given other medicines along with this medicine depending on what caused the ulcer. You need to keep taking the medicine as it is prescribed for it to be effective, even if the symptoms seem to disappear.

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Side effects of Makrab O Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Makrab O

Headache
Constipation
Fatigue
Diarrhea
Nausea
Vomiting
Pain
Sore throat
Infection
Abdominal pain

How to use Makrab O Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Makrab O 4mg/20mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Makrab O Tablet works

Makrab O 4mg/20mg Tablet is a combination of two medicines: Ondansetron and Rabeprazole. Ondansetron is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting. Rabeprazole is a proton pump inhibitor (PPI) which works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Makrab O 4mg/20mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Makrab O 4mg/20mg Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Makrab O 4mg/20mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Makrab O 4mg/20mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Makrab O 4mg/20mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Makrab O 4mg/20mg Tablet in patients with liver disease. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Makrab O 4mg/20mg Tablet

₹6.87/Tablet

Rafron Total Tablet

Saffron Formulations Pvt Ltd

₹15.2/tablet

121% costlier

Sizfire O 4mg/20mg Tablet

Hauz Pharma Pvt Ltd

₹8.91/tablet

30% costlier

Rabicer O Tablet

Biochem Pharmaceutical Industries

₹9.81/tablet

43% costlier

Rebozen ON 4mg/20mg Tablet

Leeford Healthcare Ltd

₹8.21/tablet

20% costlier

Rowet OD 4mg/20mg Tablet

Aden Healthcare

₹7.36/tablet

7% costlier

View all substitutes

Quick tips

Makrab O 4mg/20mg Tablet is used to give relief from nausea, vomiting as well as acidity, heartburn and other discomfort associated with acid reflux and peptic ulcer disease.
It is advisable to take your doses about half an hour before meals.
If you vomit within one hour of taking a dose, take another dose.
Avoid taking soft drinks, citrus fruits like orange and lemon, which can irritate the stomach and increase acid secretion.
Incorporate the following lifestyle changes in order to prevent acidity:
1. Make sure you eat regular meals and drink plenty of water.
2. Avoid spicy and fatty fried food.
3. Lose weight if you are obese.
4. If you are a smoker, consider giving up.
5. Don't drink too much alcohol.
6. Do not go to bed immediately after taking a meal. Sit in a relaxed position for sometimes for better digestion.

Fact Box

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Patient concerns

Gastric nausea vomiting reflux

Dr. Pushkar Mani

Physician

sompraz D 40 mg twice daily 1 hour before meal for 10 days

Heartburn Mental disorder Depression Frequent persistent heartburn Gastroesophageal reflux disease Irritable bowel syndrome Indigestion Back flow of acid from stomach Difficulty in swallowing Inflammation of esophagus Excess acid secretion by stomach Intestinal or stomach ulcers

Dr. Sunil Sekhri

Diabetology

You need to be examined in clinic to reach a diagnosis and then appropriate medicine can be prescribed

Suffering from acid reflux disease due to which pain in throat and right side of lower abdomen

Dr. Saurav Arora

Homeopathy

Dear sir for the time being you can take Robinia 30, 04 drops in half cup water and Nixocid tab 2 tab thrice daily for a month, but as this case needs supervision, discussion and examination you need to visit a homeopath so that he can discuss your case in detail, get some investigations, do examination and guide you accordingly,

Top Physicians

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Sharkey KA, MacNaughton WK. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill Education; 2018. pp. 922-944.
Hoogerwerf WA, Pasricha PJ. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 967-981.
McQuaid KR. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 1067-1101.

Marketer details

Name: Maksun Biotech Pvt Ltd

Address: FIRST FLOOR,NANHERA ROAD, KULDEEP NAGAR,AMBALA CANTT 133004 (HARYANA). INDIA

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.