Leucovorin Injection is given as a slow injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.

Injection site reactions (pain, swelling, redness) are common side effects of this medicine. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Regular blood tests are required to check your blood cells and serum methotrexate concentration in blood.

Before taking it, tell your doctor if have seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using, especially phenytoin for your seizures. To make sure it is safe for you, let your doctor know if you are pregnant or breastfeeding before taking this medicine.

Uses of Leucovorin Injection

Benefits of Leucovorin Injection

In Prevention of Harmful effects of methotrexate

Leucovorin Injection helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Leucovorin Injection will prevent the other side effects such as anemia.

Side effects of Leucovorin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Leucovorin

Injection site reactions (pain, swelling, redness)

How to use Leucovorin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Leucovorin Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Leucovorin Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Leucovorin Injection during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Leucovorin Injection does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Leucovorin Injection in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Leucovorin Injection in patients with liver disease. Please consult your doctor.

What if you forget to take Leucovorin Injection?

If you miss a dose of Leucovorin Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

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For informational purposes only. Consult a doctor before taking any medicines.

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Quick tips

You have been prescribed Leucovorin Injection to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucovorin Injection may counteract the antiepileptic effects.
You have been prescribed Leucovorin Injection to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucovorin Injection may counteract the antiepileptic effects.
You have been prescribed Leucovorin Injection to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucovorin Injection may counteract the antiepileptic effects.

Fact Box

Chemical Class

Glutamic acid Derivatives

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Folic Acid Analogs

Patient concerns

Common cold with bronchitis fever two days Fever with common cold & bronchitis

Dr. Gopal Bansilal Samdani

Paediatrics

There are many underlying causes of your symptoms. Different cause needs different treatment. Specific treatment cannot be given unless we establish exact underlying cause. Final and perfect diagnosis cannot be done without doing clinical examination of child. Please consult me or any other Paediatrician. will take detail history and will examine your child in detail. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. At time may ask you relevant investigations if necessary. Your child may need antibiotics and/or other prescription drugs.

Common cold and fever, headache, body ache,

Dr. Vijay Verma

ENT

Take tab lcz plus at bedtime for two days and tab paracetamol 500mg three times a day for two days in case no improvement in two days visit ent specialist near you for proper examination

Suffering from fever, cough and cold headache and boadache

Dr. Gopal Bansilal Samdani

Paediatrics

Monitor temperature of Patient. If Patient has fever place a cool, damp washcloth on your child's forehead. Give your Patient a lukewarm tub bath or a sponge bath. Give a sponge bath as follows: - ? Use lukewarm water [90?F (32.2?C) to 95?F (35?C)]. Do not use cold water, ice, or rubbing alcohol, which will lower the child's body temperature too quickly. ? Sponge for 20 to 30 minutes. ? Stop if the child starts to shiver. If your child doesn't like the sponge bath or doesn't feel better after the bath, there is no need to give another one. You can use paracetamol also along with above measures to control fever till you consult Dr. will determine underlying disorders by clinical examination which range from mild conditions to the most serious of bacterial and viral illnesses and will prescribe medicines accordingly. Advice given without doing clinical examination can be imperfect or some time harmful to patient.

User feedback

Patients taking Leucovorin Injection

Once A Day

40%

Once A Week

20%

Alternate Day

20%

Thrice A week

20%

FAQs

What is Leucovorin Injection used for?

Leucovorin Injection is used to prevent harmful effects of methotrexate (cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Leucovorin Injection is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.

What is megaloblastic anemia?

Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency. How long does it take for Leucovorin Injection to work?

How long does it take for Leucovorin Injection to work?

Leucovorin Injection starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What are some of the laboratory tests conducted before or during the treatment with Leucovorin Injection?

Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Leucovorin Injection. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Leucovorin Injection contains calcium.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Leucovorin Injection?

Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Calcium folinate. Hurley, Maidenhead: Hospira UK Ltd.; 2003 [revised Jan. 2018]. [Accessed 26 Mar. 2019] (online) Available from:
Levoleucovorin. Parsippany, New Jersey: Actavis Pharma; 1952 [revised Sep. 2016]. [Accessed 26 Mar. 2019](online) Available from:

Marketer details

Name: Dabur India Ltd

Address: 8/3, Asaf Ali Road, New Delhi-110002

Country of origin: India

₹242

Inclusive of all taxes

MRP₹250 3% OFF

5.0 ml in 1 vial

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Leucovorin Injection

Product introduction

Uses of Leucovorin Injection

Benefits of Leucovorin Injection

In Prevention of Harmful effects of methotrexate

Side effects of Leucovorin Injection

Common side effects of Leucovorin

How to use Leucovorin Injection

Safety advice

What if you forget to take Leucovorin Injection?

All substitutes

Quick tips

Fact Box

Patient concerns

User feedback

FAQs

What is Leucovorin Injection used for?

What is megaloblastic anemia?

How long does it take for Leucovorin Injection to work?

What are some of the laboratory tests conducted before or during the treatment with Leucovorin Injection?

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Leucovorin Injection?

Want to share the information?

Disclaimer:

References

Marketer details

Lab tests offered by us