Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
User feedback
FAQs

Author Details

Written By

Dr. Subita Alagh

BDS

Reviewed By

Dr. Rajeev Sharma

MBA, MBBS

Last updated

26 Sep 2025 | 05:38 PM (IST)

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Home>Duzela M>duzela m 20 capsule dr

Duzela M 20 Capsule DR

Prescription Required

Marketer

Sun Pharmaceutical Industries Ltd

SALT COMPOSITION

Duloxetine (20mg) + Methylcobalamin (1.5mg)

Storage

Store below 30°C

View available alternative with same salt composition

Product introduction

Duzela M 20 Capsule DR is a combination of two medicines used to treat neuropathic pain. It works by protecting the nerve fibres against damage, repairing the damaged nerves. This way it effectively relieves the pain sensation and also elevates the mood.

Duzela M 20 Capsule DR may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of the treatment even if you feel better. It is important not to stop taking this medicine suddenly.

Some common side effects of this medicine include nausea, constipation, headache, insomnia (difficulty in sleeping), ejaculation disorder, erectile dysfunction, and low sexual desire. However, these are temporary and usually resolve on their own. Please consult your doctor if these do not subside or bother you.

You should avoid alcohol while taking Duzela M 20 Capsule DR, as it may worsen certain side effects. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.

Uses of Duzela M Capsule DR

Neuropathic pain

Benefits of Duzela M Capsule DR

In Neuropathic pain

Duzela M 20 Capsule DR is a combination of medicines used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles, or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. It is thought to work by interfering with pain signals that travel through the damaged nerves and the brain. It also contains nutritional supplements that are essential for improving nerve conduction.
Duzela M 20 Capsule DR regularly will improve your physical and social functioning and overall quality of life. It takes a few weeks to work so you need to take it regularly even if you feel it is not doing any good. Once your symptoms have gone you should still keep taking the medicine until your doctor advises you to stop.

Side effects of Duzela M Capsule DR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Duzela M

Nausea
Constipation
Headache
Insomnia (difficulty in sleeping)
Ejaculation disorder
Erectile dysfunction
Low sexual desire

How to use Duzela M Capsule DR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duzela M 20 Capsule DR may be taken with or without food, but it is better to take it at a fixed time.

How Duzela M Capsule DR works

Duzela M 20 Capsule DR is a combination of two medicines:

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Duzela M 20 Capsule DR.

Pregnancy

CONSULT YOUR DOCTOR

Duzela M 20 Capsule DR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Duzela M 20 Capsule DR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Duzela M 20 Capsule DR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Duzela M 20 Capsule DR should be used with caution in patients with severe kidney disease. Dose adjustment of Duzela M 20 Capsule DR may be needed. Please consult your doctor.
Dose adjustment is not recommended in patients with mild and moderate kidney disease.

Liver

UNSAFE

Duzela M 20 Capsule DR is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

What if you forget to take Duzela M Capsule DR?

If you miss a dose of Duzela M 20 Capsule DR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Duzela M 20 Capsule DR is used to treat certain types of long-lasting pain caused by damage to nerves.
It may ease the pain within a few days but it may take 2-3 weeks before you see maximum benefit.
Inform your doctor if you are taking any other pain-relieving medicines.
Along with taking this medicine, your doctor might advise you to undergo physiotherapy to get relief from pain.
You might experience low sexual desire after taking Duzela M 20 Capsule DR, talk to your doctor if it troubles you.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

I surfing from cervical spondylosis and back head pain so please suggest me

Dr. Vikas Sharma

Neurology

Cap duzela 20 mg bd

left hand pen in night three days

Dr. Vikas Sharma

Neurology

get examined by neuro dr; start cap duzela 20 mg at nite

User feedback

Patients taking Duzela M 20 Capsule DR

Once A Day

82%

Twice A Day

17%

Alternate Day

What are you using Duzela M Capsule DR for?

Neuropathic p*

57%

Others

22%

Depression

Diabetic nerv*

Nutritional d*

*Neuropathic pain, Diabetic nerve pain, Nutritional deficiencies

How much was the improvement?

Average

49%

Poor

46%

Excellent

What were the side-effects while using Duzela M 20 Capsule DR?

Ejaculation d*

13%

Sleepiness

13%

No Side Effec*

13%

Insomnia (dif*

13%

Blurred visio*

*Ejaculation disorder, No Side Effect, Insomnia (difficulty in sleeping), Blurred vision

How do you take Duzela M Capsule DR?

With food

80%

With or witho*

20%

*With or without food

Please rate Duzela M 20 Capsule DR on price

Average

74%

Expensive

19%

Not Expensive

FAQs

What is Duzela M 20 Capsule DR used for?

Duzela M 20 Capsule DR is mainly prescribed for treating neuropathic pain (nerve pain), such as that seen in diabetic neuropathy, or other nerve-related issues. Duloxetine in Duzela M 20 Capsule DR is an antidepressant that reduces nerve pain, while methylcobalamin (active vitamin B12) in Duzela M 20 Capsule DR helps restore and protect nerve function.

What precautions should I consider before taking Duzela M 20 Capsule DR?

Before taking Duzela M 20 Capsule DR, tell your doctor if you have a history of liver or kidney disease, glaucoma, mania, or seizures, bleeding disorders, bipolar disorder, or if you drink large amounts of alcohol. Also, mention to your doctor if you are pregnant, breastfeeding, or using other medications.

Who should not use Duzela M 20 Capsule DR?

Individuals should not use Duzela M 20 Capsule DR if they are allergic to duloxetine, methylcobalamin, or any other ingredients present in it. Duzela M 20 Capsule DR must not be taken with medications called monoamine oxidase inhibitors (MAOIs), and it is not recommended for people with severe liver or kidney impairment, or uncontrolled glaucoma (narrow angle).

What are the serious side effects of Duzela M 20 Capsule DR?

Serious side effects of Duzela M 20 Capsule DR include allergic reactions (swelling, rash, trouble breathing), severe skin reactions, liver problems (yellowing of eyes, or skin, dark urine), abnormal mood, or behavior changes (thoughts of self-harm), easy bruising, or signs of serotonin syndrome (agitation, fast heartbeat, hallucinations, muscle stiffness, or vomiting). Seek immediate medical help if you experience any of these symptoms.

Is Duzela M 20 Capsule DR addictive?

No, Duzela M 20 Capsule DR is not habit-forming or addictive when used as prescribed by your doctor.

How long will Duzela M 20 Capsule DR take to show benefits, and how long should I keep taking it?

The exact time Duzela M 20 Capsule DR takes to show benefits is not known. However, relief from nerve pain may begin within a few weeks, but the full effect can take 2 to 4 weeks of regular use. Do not stop taking this medicine suddenly, and always follow your doctor’s advice for starting or stopping Duzela M 20 Capsule DR.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Duloxetine hydrochloride. Basingstoke, Hampshire: Eli Lilly and Company Limited; 2004 [revised 09 Nov. 2018]. [Accessed 23 Apr. 2019] (online) Available from:
MedlinePlus. Vitamin B-12. [Accessed 23 Apr. 2019] (online) Available from:
Gupta JK, Sana QS. Potential Benefits of Methylcobalamin: A Review. Austin J Pharmacol Ther. 2015;3(3):1076. [Accessed 23 Apr. 2019] (online) Available from: