Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Mayank

Pharm.D

Reviewed By

Dr. Rajeev Sharma

MBA, MBBS

Last updated

01 Nov 2025 | 04:20 PM (IST)

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Cosam 400 Tablet

Prescription Required

Marketer

Chondrion Lifesciences Pvt Limited

SALT COMPOSITION

Ademetionine (400mg)

Salt Synonyms

S-Adenosyl L-Methionine

Storage

Store below 25°C

View available alternative with same salt composition

Product introduction

Cosam 400 Tablet is a medicine used in the treatment of intrahepatic cholestasis and other chronic liver diseases. It works by restoring the natural compound in the liver that helps protect liver cells from damage, improves the flow of bile, and supports overall healthy liver function.

Cosam 400 Tablet is usually recommended to be taken before meals, as this improves absorption. The exact dose depends on your body weight and the condition being treated. To get the most benefit, it is important to take this medicine regularly and at the same time each day. Treatment may need to continue for several months or longer, depending on your doctor’s advice. Even if your symptoms improve, do not stop taking it unless your doctor tells you to.

The most common side effects of Cosam 400 Tablet are nausea, abdominal discomfort, and diarrhea. These effects are usually mild and temporary. If diarrhea becomes bothersome, your doctor may adjust your dose or stop the treatment. Drinking plenty of fluids can help prevent dehydration if you experience diarrhea or constipation. Rarely, some people may also experience a headache, trouble sleeping, or a skin rash. If any side effect worries you, consult with a doctor.

Cosam 400 Tablet should be used with caution in patients with a history of bipolar disorder, as this medicine may rarely trigger mood swings. Use during pregnancy and breastfeeding should only be under medical advice. This medicine can interact with other drugs, so let your doctor know about all the medicines and supplements you are taking. Avoid drinking alcohol while on treatment, as this may increase the strain on your liver and worsen side effects.

Uses of Cosam Tablet

Treatment of Liver disease

Benefits of Cosam Tablet

In Treatment of Liver disease

Cosam 400 Tablet is used in the management of liver disease, including conditions such as intrahepatic cholestasis and chronic liver disorders. It supports the liver’s natural detoxification processes, helps restore antioxidant levels like glutathione, and improves bile flow. It protects liver cells and promotes their healthy function, playing an important role in maintaining overall liver health.

Side effects of Cosam Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Cosam

Nausea
Diarrhea
Abdominal pain

How to use Cosam Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cosam 400 Tablet is to be taken empty stomach.

How Cosam Tablet works

Cosam 400 Tablet works by helping the liver make and restore important substances that protect its cells. It increases the liver’s natural antioxidants, reduces damage from toxins, and improves the flow of bile. This supports healthier liver function in conditions like intrahepatic cholestasis and chronic liver disease.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Cosam 400 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Cosam 400 Tablet during pregnancy is not available. Please consult your doctor.
High doses used in late pregnancy have not shown harmful effects. However, in the first trimester, use only if clearly needed, and always under medical supervision.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Cosam 400 Tablet during breastfeeding is not available. Please consult your doctor.
Use during breastfeeding only if the expected benefit to the mother outweighs the possible risk to the baby.

Driving

UNSAFE

Cosam 400 Tablet may cause side effects which could affect your ability to drive.
This medicine may cause dizziness. Do not drive or operate machinery until you know how it affects you.

Kidney

CAUTION

Cosam 400 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Cosam 400 Tablet may be needed. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Cosam 400 Tablet is safe to use in patients with liver disease. No dose adjustment of Cosam 400 Tablet is recommended.

What if you forget to take Cosam Tablet?

If you miss a dose of Cosam 400 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
To make sure it is safe for you, consult with your doctor if you are pregnant, planning pregnancy, or breastfeeding before starting this medicine.
Follow a healthy diet, avoid alcohol, and keep yourself well hydrated to complement the treatment.
Inform your doctor if you have bipolar disorder or a history of mood swings; this medicine may trigger mania/hypomania.
Tell your doctor if you have rare genetic problems affecting methionine metabolism (e.g., homocystinuria).
Your doctor may check vitamin B12 and folate levels during treatment.

Fact Box

Chemical Class

Amino acid derivative

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Hepatoprotective Agents

Patient concerns

Fatty liver disease with enlarged liver

Dr. Aanchal Maheshwari

Ayurveda

Take cytozen capsule twice, lavanbhasksr churan half spoon twice

Liver disease due to fatty liver

Dr. Deepak Kumar Soni

Ayurveda

Hi kindly share your reports

What is Cosam 400 Tablet used for?

Cosam 400 Tablet is mainly used for the treatment of intrahepatic cholestasis, a condition in which the flow of bile from the liver is reduced, and in certain liver diseases. It helps improve bile secretion and protect liver cells from damage. This helps relieve symptoms such as itching, tiredness, and digestive discomfort that often occur in these conditions.

How does Cosam 400 Tablet work in liver disease?

Cosam 400 Tablet is a natural substance produced in the body that plays an important role in liver health. In people with liver disease, its levels are usually lower than normal. Taking Cosam 400 Tablet helps restore these levels, which improves bile flow, protects liver cells from harmful toxins and oxidative stress, and supports the liver’s natural detoxification functions. This way it helps the liver work more effectively and reduce the complications associated with cholestasis and other liver problems.

How should Cosam 400 Tablet be taken?

Take Cosam 400 Tablet exactly as prescribed by your doctor. The dose and duration of treatment depend on your medical condition, response to treatment, and your doctor’s judgment. Stopping or changing the dose on your own is not advised, as it may affect the effectiveness of treatment.

Is Cosam 400 Tablet safe during pregnancy or breastfeeding?

Cosam 400 Tablet should only be used during pregnancy or breastfeeding if it is clearly recommended by your doctor. The safety of this medicine in these conditions has not been fully established, so medical supervision is essential. Always consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding.

Can I take Cosam 400 Tablet with other medicines?

You should inform your doctor about all other medicines, supplements, or herbal products that you are currently taking. This will help your doctor decide if Cosam 400 Tablet is safe to use alongside them and will reduce the risk of any possible interactions that could affect your treatment or overall health.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Sept. 2025] (online) Available from:
Ademetionine [Product Label]. Ahmedabad, Gujarat: La Renon Healthcare Private Limited; 2022. [Accessed 04 Sept. 2025] (online) Available from:
MIMS Malaysia: Ademetionine [Full Prescribing Information]. [Accessed 04 Sept. 2025] (online) Available from:
Ademetionine [Product Information]. Turkey: World Medicine İlaç San. ve Tic. А.Ş. [Accessed 04 Sept. 2025] (online) Available from:
Zeelab Pharmacy: Ademetionine [Product Information]. [Accessed 04 Sept. 2025] (online) Available from: