Aprezo Tablet

Prescription Required


Aprezo Tablet is used in the treatment of moderate to severe plaque psoriasis which is a type of skin condition. This medicine is used when other conventional treatments cannot be used or if the patient is not responsive or intolerant to any of these treatments.

Aprezo Tablet can be taken with or without food. Take it regularly and do not stop taking the medicine even if you get better until that doctor tells you it is alright to stop. You may need to monitor your weight regularly while taking the medicine as it may cause weight loss.

Using this medicine may cause few common side effects such as nausea, diarrhea, and vomiting. If these side effects persist or get worse, let your doctor know. Your doctor may help with ways to reduce or prevent these symptoms by prescribing you an alternative medicine or by adjusting the dose.

To make sure the medicine is safe for you, before taking this medicine, let your doctor know all the other medicines you are taking. If you are pregnant or breastfeeding, consult your doctor first before taking this medicine.

Uses of Aprezo Tablet

  • Plaque psoriasis

Benefits of Aprezo Tablet

In Plaque psoriasis

Plaque psoriasis is the most common form of psoriasis, a condition where the skin cells in the body grow too quickly and form scales and dry patches. They can grow anywhere, but most appear on the scalp, elbows, knees, and lower back. Aprezo Tablet reduces the scaly, itchy patches which may develop on the different parts of the body. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Aprezo Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Aprezo

  • Diarrhea
  • Nausea
  • Vomiting

How to use Aprezo Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aprezo Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Aprezo Tablet works

Aprezo Tablet is a phosphodiesterase 4 (PDE4) inhibitors. It works by blocking the action of certain chemical messengers that are responsible for inflammation associated with psoriatic arthritis and psoriasis, and thereby reduces the signs and symptoms of these conditions.

Safety advice

Caution is advised when consuming alcohol with Aprezo Tablet. Please consult your doctor.
Aprezo Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
Information regarding the use of Aprezo Tablet during breastfeeding is not available. Please consult your doctor.
Aprezo Tablet does not usually affect your ability to drive.
Aprezo Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Aprezo Tablet may be needed. Please consult your doctor.
Aprezo Tablet is safe to use in patients with liver disease. No dose adjustment of Aprezo Tablet is recommended.

What if you forget to take Aprezo Tablet?

If you miss a dose of Aprezo Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Aprezo Tablet
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Quick tips

  • Aprezo Tablet is a well-tolerated medicine. Mild stomach upset may occur early during the treatment.
  • Monitor your weight regularly as Aprezo Tablet may cause weight loss.
  • Your doctor will gradually increase the dose from day 1 to day 6 of treatment, after which it may be kept constant.
  • Tell your doctor immediately if you experience new or worsened depression, suicidal thoughts, other mood changes or unexplained weight loss.

Fact Box

Chemical Class
Isoindole Derivative
Habit Forming
Therapeutic Class
Action Class
Phosphodiesterase-IV inhibitors (PsA & PSO)

Patient concerns

I have plaque psoriasis. and suddenly I got pustular psoriasis in other areas where skin was normal. now it pains a lot at the affected area
Dr. Souvik Sardar
See these are diseases wch can't be treated by online consultation U need to visit a dermatologist for a face to face consultation and examination Many things are to be considered before prescribing medicines in these cases
How to remove plaque any medicine or plaque removal suggest me
Dr. Rohan Bhatt
Dental Surgery
go for teeth scaling once

User feedback


Q. Is Aprezo Tablet an immunosuppressant?

No, Aprezo Tablet is not an immunosuppressant. It belongs to a class of medicines known as phosphodiesterase 4 inhibitors (PDE4) which work by blocking the activity of PDE4. PDE4 is found in inflammatory cells and blocking it helps in reducing the molecules responsible for inflammation.

Q. How long does it take for Aprezo Tablet to work?

Aprezo Tablet is used to treat plaque psoriasis (red, scaly, thick, itchy, painful patches on skin) and psoriatic arthritis (a condition that causes joint pain and swelling). It is a long-term treatment and may take about 16 weeks to show an improvement.

Q. Can Aprezo Tablet cause depression?

Yes, Aprezo Tablet may cause depression as a side effect. The patient may also develop suicidal thoughts. It should be avoided in patients with a history of depression. In case you develop any of these symptoms, consult your doctor immediately or ask your friends or relatives to help seek medical advice.

Q. Does Aprezo Tablet cause weight reduction?

Yes, Aprezo Tablet may cause a decrease in appetite which may further cause weight loss. You should monitor your weight regularly while on treatment with Aprezo Tablet. In case of significant weight loss, consult your doctor and consider stopping Aprezo Tablet.

Q. How should Aprezo Tablet be taken?

Be sure to take Aprezo Tablet exactly as directed by your doctor. Your doctor will prescribe a low dose initially. This dose will be increased gradually after 6 days. Swallow the tablets whole with water. You can take it with or without food.

Q. Can I take rifampicin along with Aprezo Tablet?

You should not take rifampicin if you are taking Aprezo Tablet. Rifampicin interferes with the working of Aprezo Tablet by decreasing its levels, making it less effective. As a result, you may not see any improvement after taking Aprezo Tablet.

Q. What if I get pregnant during treatment with Aprezo Tablet?

In case you get pregnant while taking Aprezo Tablet, you should inform your doctor immediately. In fact, pregnancy should be avoided during treatment with this medicine. The reason being, according to animal studies, with Aprezo Tablet there may be a risk of baby loss or defects in unborn baby.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Medscape. Apremilast. [Accessed 02 Apr. 2019] (online) Available from:External Link
  2. National Drug Monograph. Apermilast; 2015. [Accessed 02 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Country of origin: India

Expires on or after: July, 2022

A licensed vendor partner from your nearest location will deliver Aprezo Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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