Pigolyn

Trioxsalen is a photosensitive medication used with UV-A rays. It works by activating certain skin cells (melanocytes) and helps repigment the discolored, white patches in vitiligo. Trioxsalen also slows down the rapid growth of skin cells in psoriasis. This reduces scaling and thickening of the skin.

In Depth Information for Pigolyn Products

Trioxsalen is a very strong medicine that increases your skin sensitivity to sunlight. Do not use it for sun tanning or to increase tolerance to sunlight; if doing so, do not use trioxsalen for more than 14 days.
Take this treatment (trioxsalen and UVA) two or three times a week with the treatment spaced at least forty-eight hours apart.
Take this medication by mouth with food or milk, usually 2 to 4 hours before your UVA light treatment.
Do not sunbathe for 24 hours before taking trioxsalen. Wear UVA-absorbing, wrap-around sunglasses and cover exposed skin or use a sunblock (SP 15 or higher) for the twenty-four (24) hour period following treatment with trioxsalen.
Use extra caution for at least 48 hours following each treatment. After each treatment, cover your skin for at least 8 hours by wearing protective clothing.
Do not increase the amount of trioxsalen if you are taking or spend extra time in the sunlight or under an ultraviolet lamp.
Do not drive or operate machinery as trioxsalen may cause dizziness.
You will need to have an eye examination before starting trioxsalen and also once a year thereafter.
Be careful before applying anything to your skin to treat dryness and itchiness caused by trioxsalen.
Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Patient Concerns about Pigolyn Products

Frequently asked questions about Pigolyn Products

Q. What is Pigolyn 0.2% Cream used for?

Pigolyn 0.2% Cream is mainly used in the treatment of vitiligo, which causes white patches on the skin, and psoriasis, a condition characterized by thickened or scaly skin.

Q. How does Pigolyn 0.2% Cream work for skin conditions?

Pigolyn 0.2% Cream makes the skin more sensitive to ultraviolet (UV) light. When combined with controlled UV therapy (PUVA), it activates pigment-producing cells and promotes the regaining of normal skin color in vitiligo or slows excess skin cell growth in psoriasis.

Q. Who should not use Pigolyn 0.2% Cream on their skin?

Individuals should not use Pigolyn 0.2% Cream if they are allergic to psoralens or any other ingredient present in it, or if they have a history of skin cancer, lupus, or other photosensitive conditions. Always check with your doctor before starting treatment.

Q. Can Pigolyn 0.2% Cream cause serious side effects?

Yes, Pigolyn 0.2% Cream can cause severe skin redness, swelling, painful blisters, skin peeling, allergic reactions, or excessive sun sensitivity. If you experience any of these, stop treatment and seek medical help.

Q. Is there a risk of skin cancer with Pigolyn 0.2% Cream?

Long-term use of name Pigolyn 0.2% Cream combined with excessive UV exposure may increase the risk of premature skin aging or skin cancer. Regular doctor checkups during treatment are important.

Q. Can I go into direct sunlight after using Pigolyn 0.2% Cream?

No, you must avoid natural sunlight after Pigolyn 0.2% Cream application without protective clothing or sunscreen, as it dramatically increases the risk of sunburn and skin damage.

Information last updated by Dr. Varun Gupta, MD Pharmacology on 25th Nov 2025.
The medicine details are for information purpose only. Consult a doctor before taking any medicine.