Fisofine

Lidocaine + Nifedipine is a combination of two medicines: Lidocaine + Nifedipine1 and Lidocaine + Nifedipine2. Lidocaine + Nifedipine1 is a local anesthetic. It works by blocking pain signals from the nerves to brain which decreases pain sensation. Lidocaine + Nifedipine2 is a calcium channel blocker (CCB). It works in anal fissure by blocking the action of calcium on blood vessels of anus.

In Depth Information for Fisofine Products

It is for administration into the rectum (back passage). It must not be taken by mouth.
Use the applicator provided to insert a measured dose of cream into your back passage.
Avoid getting it in the eyes, mouth or nose. Rinse with cold water if you accidentally get it in these areas.
Tips to treat constipation caused by anal fissure:
- Drink plenty of fluids to stay hydrated.
- Have fiber-rich food such as whole grains, oatmeal, and citrus fruits.
- Exercise regularly.
- Do not sit on the toilet for too long.
- Do not ignore your urge to go to the washroom.

Patient Concerns about Fisofine Products

Frequently asked questions about Fisofine Products

Q. Does Fisofine Cream cure anal fissures?

No, it does not cure fissures but Fisofine Cream reduces inflammation of mucous membrane and skin. It reduces irritation, alleviates pain and itching, thus providing symptomatic relief.

Q. Why is my fissure not healing?

Fissures usually heal within a few weeks. But if they are not, this is because the oxygen supply, carried by the blood, to these fissures is poor which further slows down the healing process. As a result, these fissures fail to heal and continue to get worse. You should consult a doctor immediately if you have been facing issues for a duration longer than a few weeks.

Q. What should I eat and avoid in fissure?

You must take a fiber-rich diet such as vegetables, fresh fruits and whole grains if you have fissures. Drink plenty of water and avoid taking alcohol. This will ensure that your stools are soft and easy to pass. You may also take laxatives or fiber supplements if you are facing issues with digestion. Your doctor will suggest ways to avoid constipation and thereby promote healing of fissures.

Q. Can spicy food cause fissures?

No. Spicy foods do not cause fissures. But, they can irritate the fissures and worsen your symptoms. Therefore, it is advised that you avoid taking spicy foods if you are facing issues with your fissures.

Q. How do you use Fisofine Cream cream?

Follow your doctor’s instructions before using Fisofine Cream. Apply a small amount of the ointment to the affected rectal area as directed. If this is to be used inside the rectum, attach the rectal applicator onto the tube. Insert the applicator gently and to full extent into the rectum. Gently squeeze the tube to deliver the medication while withdrawing it.

Q. How long does it take to heal fissures?

Fissures usually heal within a few weeks. But, if they persist for longer than 4 to 6 weeks, they are termed as chronic fissures. Please consult your doctor without any delay if you have been noticing fissures for longer than 4 weeks.

Information last updated by Dr. Varun Gupta, MD Pharmacology on 25th Nov 2025.
The medicine details are for information purpose only. Consult a doctor before taking any medicine.