Esomeprazole + Itopride is a combination of two medicines: Esomeprazole + Itopride1 and Esomeprazole + Itopride2. Esomeprazole + Itopride1 is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn. Esomeprazole + Itopride2 is a prokinetic which works on the region in the brain that controls vomiting. It also acts on the upper digestive tract to increase the movement of the stomach and intestines, allowing food to move more easily through the stomach.