TB DNA Detection by Realtime PCR, Reflex to Rifampicin Resistance by Ultra CBNAAT (if Positive), Urine

Tuberculosis, or TB, is a contagious disease caused by bacteria called Mycobacterium tuberculosis. It primarily affects the lungs, but can also impact other parts of the body. It spreads through the air when an infected individual coughs, sneezes, or speaks, releasing droplets that can be inhaled by others. Early and accurate diagnosis is essential for timely treatment and limiting TB transmission. 

The TB DNA Detection by Realtime PCR, Reflex to Rifampicin Resistance by Ultra CBNAAT (if Positive), Urine test uses real-time PCR technology to find out the DNA of TB bacteria in a urine sample. If TB is detected, this test automatically reflexes to check for resistance to rifampicin, one of the key antibiotics in the Anti-Tuberculosis Treatment regimen (ATT) using Ultra Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) method. This two-step process allows not only quick identification of TB bacteria but also determines if the strain is drug-resistant, enabling targeted treatment.

The TB DNA Detection by Realtime PCR, Reflex to Rifampicin Resistance by Ultra CBNAAT (if Positive), Urine test helps detect genitourinary TB. It is useful for individuals who are unable to produce sputum, such as children or those suspected to have TB in organs other than the lungs. It is advised when there are symptoms such as painful and frequent urination, urinary urgency, and blood or pus in the urine, suggestive of genitourinary TB. Also, it is advised for individuals with a history of TB exposure, HIV infection, or immunocompromised conditions.

It is important to note that the TB DNA Detection by Realtime PCR, Reflex to Rifampicin Resistance by Ultra CBNAAT (if Positive), Urine test may not detect TB if the bacterial load is very low or if the sample is inadequate. Urine testing is more appropriate for individuals with suspected genitourinary or extrapulmonary TB rather than pulmonary TB.

 A mid-stream clean-catch urine sample is recommended for optimal accuracy. Also, before undertaking this test, inform the doctor about all the medications, supplements, or underlying illnesses (like HIV or previous history of TB treatment), as all these factors can influence the test results and help doctors establish a correlation with clinical and laboratory findings.

Laboratory test results may vary across different laboratories. Do not self-medicate and always consult a doctor to understand the test results correctly.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.