TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum near me in Panipat
Understanding TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum in Panipat
What is TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum in Panipat?
The TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum test is an advanced diagnostic test that checks for the DNA of Mycobacterium tuberculosis (TB) in a sputum sample. It is done to find out if the TB bacteria are resistant to rifampicin, one of the main medicines used to treat TB. This test is widely available with Tata 1mg labs at an affordable price in Panipat.
The TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum test is an advanced molecular diagnostic test designed to detect the presence of Mycobacterium tuberculosis (MTB) in a sputum sample. This test uses the Xpert MTB/RIF Ultra assay on the GeneXpert Instrument System for rapid and precise detection of MTB complex DNA. If TB is detected, the test also checks for rifampicin resistance by identifying mutations in the rpoB gene. Rifampicin resistance is a key indicator of multidrug-resistant TB (MDR-TB).
This test is best suited for patients with clinical suspicion of tuberculosis (TB) when used in conjunction with clinical and other laboratory findings. Testing helps in early initiation of TB treatment and assists in guiding personalized TB therapy. Additionally, this panel aids in monitoring treatment response and assessing the risk of transmitting TB to others. This technology is highly sensitive in comparison to smear microscopy, enabling more people with MTB infections to be detected and treated earlier.
Collect sputum in a sterile, leak-proof container with a screw-cap lid. Before collecting the sample, rinse your mouth with clean water. Take two to three deep breaths, then cough deeply to bring up sputum from the lungs. Ensure you collect at least 2 ml of thick, yellowish (muco purulent) sputum. Avoid collecting only saliva or nasal secretions. As per National Tuberculosis Elimination Programme (NTEP) guidelines, testing requires two sputum samples. This may include a spot and early morning sample collected on consecutive days, or two spot samples collected one hour apart, for accurate diagnosis of tuberculosis (TB).
What does TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum measure?
The TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum test measures the presence of Mycobacterium tuberculosis (MTB) DNA in a sputum sample using advanced molecular technology. If TB bacteria are detected, the test also checks for mutations in the rpoB gene, which are associated with resistance to rifampicin, a key first-line drug used in TB treatment. Rifampicin resistance is often an indicator of multidrug-resistant TB (MDR-TB). By detecting both the TB bacteria and potential drug resistance, the test helps in identifying not only the infection but also the type of treatment that may be required for effective management.
Frequently Asked Questions about TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum in Panipat
Q. What is the TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum test?
Q. Why is this test important?
Q. What sample is required for this test?
Q. Do I need to fast before the test?
Q. Is the test painful?
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Q. Is a home sample collection facility available for the TB Detection by GeneXpert Ultra MTB with Rifampicin Resistance, Sputum test in Panipat with Tata 1mg Labs?
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References
- Dorman SE, Schumacher SG, Alland D, Nabeta P, Armstrong DT, King B, Hall SL, Chakravorty S, Cirillo DM, Tukvadze N, Bablishvili N, Stevens W, Scott L, Rodrigues C, Kazi MI, Joloba M, Nakiyingi L, Nicol MP, Ghebrekristos Y, Anyango I, Murithi W, Dietze R, Lyrio Peres R, Skrahina A, Auchynka V, Chopra KK, Hanif M, Liu X, Yuan X, Boehme CC, Ellner JJ, Denkinger CM; study team. Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis. 2018 Jan;18(1):76-84. [Accessed 08 Aug. 2025]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6168783/
- Horne DJ, Kohli M, Zifodya JS, Schiller I, Dendukuri N, Tollefson D, Schumacher SG, Ochodo EA, Pai M, Steingart KR. Xpert MTB/RIF and Xpert MTB/RIF Ultra for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev. 2019 Jun 7;6(6):CD009593. [Accessed 08 Aug. 2025]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6555588/
- Diagnostic performance of Xpert MTB/RIF ultra in detecting Mycobacterium tuberculosis and Rifampicin Resistance in AFB Smear-negative Pulmonary and Extrapulmonary Tuberculosis samples in Malaysia [Internet]. ScienceDirect; [Accessed 08 Aug. 2025]. Available from: https://www.sciencedirect.com/science/article/pii/S0732889324000592
- Prasad R, Gupta N, Banka A. Multidrug-resistant tuberculosis/rifampicin-resistant tuberculosis: Principles of management. Lung India. 2018 Jan-Feb;35(1):78-81. [Accessed 08 Aug. 2025]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5760876/
- Tuberculosis: Multidrug-resistant (MDR-TB) or rifampicin-resistant TB (RR-TB) [Internet]. WHO; 20 May. 2024 [Accessed 08 Aug. 2025]. Available from: https://www.who.int/news-room/questions-and-answers/item/tuberculosis-multidrug-resistant-tuberculosis-(mdr-tb)
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