Myositis Profile IgG -(7 Antigens) near me in Kolkata

The U1-snRNP, also known as (U1 small nuclear ribonucleoprotein) test is used to detect antibodies against the U1-snRNP, a group of proteins involved in the process of RNA splicing, which is essential for proper cell function. This test helps diagnose rheumatic diseases such as mixed connective tissue disease (MCTD), and systemic lupus erythematosus (SLE). This test also helps doctors differentiate MCTD from other similar illnesses, making it easier to understand the specifics of the autoimmune response. A positive result suggests that the immune system may be attacking these proteins, leading to inflammation and potential tissue damage. The U1-snRNP test is often used when a doctor suspects an autoimmune disease and needs more specific information to confirm the diagnosis. 

The Mi-2 test checks for the presence of autoantibodies that target the Mi-2 nuclear antigen, a protein involved in gene regulation and muscle function. This test is used to help diagnose idiopathic inflammatory myopathies, such as Dermatomyositis (DM) and Polymyositis (PM), which are autoimmune diseases that cause muscle weakness and skin rashes. A positive result indicates the presence of Mi-2 antibodies, suggesting one of these conditions. A negative result means that the antibodies are not found, making these diseases less likely, but it doesn't completely rule them out. Additional tests may be needed for a more accurate diagnosis.

The Ku antibody test is used to detect antibodies against the Ku protein, which is involved in DNA repair and other cellular processes. These antibodies are associated with certain autoimmune diseases, particularly systemic sclerosis, polymyositis and overlap syndrome such as MIxed Connective tissues disease( MCTD). This test is not commonly prescribed as other autoimmune tests but it is useful in diagnosing and differentiating between autoimmune conditions when patients presents with overlapping symptoms like muscle weakness, joint inflammation etc. The presence of Ku antibodies, along with clinical findings and other laboratory tests, helps doctors tailor treatment plans and better understand the patient's autoimmune profile.

The PM-Scl test is used to detect antibodies against PM-Scl proteins, which are involved in the regulation of RNA and protein synthesis within cells. This test is primarily used to help diagnose Polymyositis (PM) and Systemic Sclerosis (SSc), specifically a form known as overlap syndrome, where symptoms of both diseases occur together. A positive result suggests the presence of these antibodies, which can indicate an autoimmune response affecting muscles, skin, and internal organs. A negative result means the antibodies are not detected, making these conditions less likely, though it doesn’t entirely rule them out. Additional tests may be needed to confirm the diagnosis or consider other autoimmune diseases.

The Jo-1 test is used to detect antibodies against the JO-1 protein, which plays a role in muscle and tissue function. Jo-1 antibody is a myositis-specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This test is primarily used to help diagnose IIM, particularly Dermatomyositis (DM) and Polymyositis (PM). It can be considered a specific marker of IIM, predominantly found in these conditions. The test is also associated with Interstitial Lung Disease (ILD), Raynaud phenomenon, arthritis, and mechanic's hands. A positive result suggests the presence of anti-synthetase syndrome (a rare autoimmune disease that affects multiple systems of the body) or a higher risk of myositis (muscle inflammation). A negative result means the antibodies are not detected, but it does not completely rule out the diagnosis of idiopathic inflammatory myositis. Further tests may be needed for a definitive diagnosis.