Myeloproliferative Neoplasm (MPN) Reflex Panel With BCR-ABL near me in Cuttack

Chronic myeloproliferative neoplasms (MPNs) are a group of blood disorders where the bone marrow produces too many red blood cells, white blood cells, or platelets. This uncontrolled cell growth can lead to complications such as blood clots, bleeding problems, or progression to acute leukemia.

The Myeloproliferative Neoplasm (MPN) Reflex Panel With BCR-ABL combines next-generation sequencing (NGS) with reflex testing to identify mutations in the BCR-ABL1, JAK2, MPL, and CALR genes. All of these genes play a vital role in the diagnosis and classification of MPNs.

This test works in a stepwise or “reflex” manner. It first screens for the BCR-ABL1 fusion gene, the hallmark of chronic myeloid leukemia (CML). If BCR-ABL1 is negative, the test reflexively analyzes other MPN-related genes known as JAK2 (including the common V617F and exon 12–15 mutations), followed by MPL and CALR if needed.

By examining these genetic regions sequentially, the test distinguishes CML (BCR-ABL–positive) from BCR-ABL–negative MPNs, such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). This comprehensive approach ensures an accurate molecular diagnosis, supports personalized treatment planning, and helps doctors monitor disease progression and treatment response effectively.

Doctors may recommend this panel if you experience symptoms such as fatigue, weakness, night sweats, or an enlarged spleen, or if you have abnormal blood counts. It is also advised for individuals with a family history of MPNs or known genetic risk factors. This test helps diagnose specific MPNs, differentiate between subtypes for appropriate treatment, monitor therapy response, and assess complication risks.

For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results.

Note: Genetic counseling can be provided. If interested, please send the request to this email id: [email protected]