MUSK Antibody

Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder that causes weakness in skeletal muscles, the muscles the body uses for movement. In MG, the immune system produces antibodies that mistakenly attack components at the neuromuscular junction, which interfere with communication between nerves and muscles.

The MUSK Antibody test checks for antibodies targeting a protein called muscle-specific kinase (MUSK). This protein plays a key role in forming and maintaining the neuromuscular junction. Most individuals with myasthenia gravis (MG) have antibodies directed against acetylcholine receptors (AChR). However, in about 10% to 15% of MG cases, AChR antibodies are not detected. In such situations, doctors may recommend the MUSK Antibody test to help confirm the diagnosis and classify the specific subtype of MG.

Doctors may also recommend this test if an individual shows symptoms like drooping eyelids (ptosis), difficulty swallowing, slurred speech, facial muscle weakness, trouble breathing, especially when AChR antibody results are negative but MG is still suspected.

No special preparation is needed before taking this test. However, a brief clinical history is preferred for getting tested. Additionally, it informs the doctor about any medications being taken or any recent infections, as these can affect results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.