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HOMA IR C - Peptide Model

Also referred as

HOMA-IR

Insulin Resistance Index

C-peptide Model

(Homeostatic Model Assessment of Insulin Resistance) C-peptide

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For men & women

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72 hours

Contains

5 tests

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The HOMA IR C - Peptide Model is a group of blood tests that check how well the body responds to insulin (insulin sensitivity) and the function of insulin-producing cells (beta cells) using the fasting blood sugar and C-peptide levels to provide important information about the overall metabolic health. This is a more advanced panel to detect insulin resistance as it measures C-peptide levels and is useful in diabetic patients receiving exogenous insulin.

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Blood

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Preparations

Overnight fasting required for 8 to 12 hours

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Understanding HOMA IR C - Peptide Model

The HOMA IR C - Peptide Model test is a simple, non-invasive way to check how well the body responds to insulin, how it uses sugar (glucose metabolism), and how well the pancreas works. This test helps detect insulin resistance, a key problem that develops when the body’s cells don’t respond well to insulin, resulting in high blood sugar levels leading to diabetes and heart diseases.

The HOMA IR C - Peptide Model uses HOMA 2; a mathematical index that determines insulin sensitivity and function of the beta cells. It is calculated from fasting blood sugar and C-peptide levels. Homeostatic model assessment (HOMA-2) is a method for assessing function of beta-cells of pancreas and estimating insulin resistance (IR) from basal (fasting) glucose and C-peptide concentrations.The C-Peptide model used C-peptide fasting (a protein released from pancreas when it secretes insulin) in place of Insulin fasting and is considered a better indicator than serum insulin itself.

The insights from HOMA IR C - Peptide Model test help doctors determine how well the body uses sugar and diagnose conditions such as insulin resistance, problems with blood sugar control, etc., and diseases like diabetes.

Usually, overnight fasting (8 to 12 hours) is required before the HOMA IR C - Peptide Model test. Do not eat or drink anything except water before the test. Inform the doctor about any medications, supplements, or herbal remedies being taken, as some may interfere with the test results and require dosage adjustments or temporary discontinuation.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to the doctor about the specific test results. The results will help doctors identify individuals at risk of metabolic dysfunction, enabling early intervention strategies such as lifestyle modifications, medications, etc. Also, the results will help doctors make informed decisions regarding medication adjustments and implement diet and lifestyle changes to optimize diabetes management and improve overall health.

What does HOMA IR C - Peptide Model measure?

Contains 5 tests

The HOMA IR C - Peptide Model test helps evaluate insulin resistance and how well the pancreas works by measuring fasting blood sugar and C-peptide levels. Unlike traditional insulin-based models, the C-peptide version of HOMA is better suited for individuals taking insulin injections, as C-peptide is not affected by injected insulin. This test gives a clearer picture of how much insulin the body is naturally making, which helps doctors understand how well the pancreas is functioning.

The test uses a formula with fasting glucose and C-peptide levels to measure insulin sensitivity. This is important for identifying individuals who are at risk of type 2 diabetes and other health problems. The HOMA IR C - Peptide Model test is also useful for tracking insulin sensitivity over time, allowing doctors to see how well treatments are working and adjust them if needed. It helps doctors and patients understand how insulin works in the body, which can help reduce the risk of diabetes and heart disease.

FBS (Fasting Blood Sugar)

The FBS (Fasting Blood Sugar) test measures the glucose level in the body under overnight fasting conditions. Glucose is the body's energy currency and is broken down through metabolism to produce energy. Hormones and enzymes produced by the liver and pancreas control this process. The hormone insulin, produced by the pancreas, regulates blood glucose levels. When these levels are high, such as after a meal, insulin is secreted to transport glucose into cells for energy production. Elevated glucose levels in the body after fasting may indicate a risk of developing prediabetes or diabetes, which can be of two types: Type 1, caused by little or no insulin production, and Type 2, caused by insulin resistance or decreased insulin production.

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C-Peptide, Fasting

The C-Peptide, Fasting test measures the level of C-peptide in the blood. C-peptide is a byproduct of insulin production in the pancreas. When the pancreas releases insulin into the blood, it also releases C-peptide in equal amounts. Therefore, measuring C-peptide levels can provide valuable insights into the body's natural production of insulin. This test is particularly useful in individuals with diabetes, as it helps determine how well their pancreas is functioning in producing insulin.

By assessing C-peptide levels, doctors can better understand an individual's insulin production capacity. This information is crucial for diagnosing and managing diabetes effectively. Additionally, the C-Peptide, Fasting test can help differentiate between type 1 and type 2 diabetes, guide treatment decisions, monitor the effectiveness of diabetes therapies, and evaluate overall pancreatic function Moreover, the C-Peptide, Fasting test plays a vital role in tailoring personalized treatment plans for individuals with diabetes, ensuring optimal management of their condition.

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Beta Cell Function

Insulin Sensitivity

HOMA-IR Index

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FAQs related to HOMA IR C - Peptide Model

What is the HOMA IR C - Peptide Model test?

The HOMA IR C - Peptide Model test checks insulin resistance and how well the pancreas works by measuring fasting C-peptide and glucose levels. It helps doctors understand how well the pancreas is making insulin, and it's especially helpful for individuals who are using insulin injections.

Are there any special preparations required before the HOMA IR C - Peptide Model test?

Yes, you must fast for 8 to 12 hours before taking the HOMA IR C - Peptide Model test. However, you can drink water. Also, inform your doctor about any medications you are taking, as some of them can affect your test results and may need to be adjusted or temporarily discontinued before the test.

What are the risks associated with the HOMA IR C - Peptide Model test?

The risks associated with this test are generally minimal. However, some people may experience mild pain or discomfort at the site from where the blood sample is taken, which is usually self-limiting.

Why is the HOMA IR C - Peptide Model test preferred over the regular HOMA IR test?

The HOMA IR C - Peptide Model test is preferred for individuals who take external insulin (exogenous insulin), as C-peptide levels reflect the body's natural insulin production. In contrast, the regular HOMA IR test uses insulin levels, which can be influenced by insulin injections.

What conditions can the HOMA IR C - Peptide Model test help diagnose?

This test is commonly used to assess insulin resistance, helping in the diagnosis and management of conditions such as type 2 diabetes, metabolic syndrome, polycystic ovary syndrome (PCOS), and insulinoma.

Can the HOMA IR C - Peptide Model test be used for individuals who are not on insulin therapy?

Yes, the test can be used for individuals not on insulin therapy, but it is particularly useful for those on exogenous insulin, as C-peptide reflects the pancreas's natural insulin production without being affected by insulin injections.

How is the test different from other blood glucose or insulin tests?

While other tests measure blood glucose or insulin levels directly, the HOMA IR C - Peptide Model test combines glucose and C-peptide levels to offer a more comprehensive assessment of insulin resistance, particularly in individuals on insulin therapy, providing a better understanding of endogenous insulin production.

What do the results of the HOMA IR C - Peptide Model test indicate?

The test results provide a quantitative measure of insulin resistance and beta-cell function. A higher result may indicate a greater degree of insulin resistance, which can increase the risk of developing type 2 diabetes or other metabolic conditions.

How often should I book the HOMA IR C - Peptide Model test?

The frequency of getting the HOMA IR C - Peptide Model test depends on your health condition and diabetes status. However, it is best to follow your doctor's recommendations.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MD Lab Medicine, MBBS

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Last Updated

8th Nov 2025