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Anti ds-DNA Antibody, EIA

Also referred as

Anti-dsDNA Test

Antibody to ds-DNA

Native double-stranded DNA Antibody

anti-DNA Double stranded DNA Antibody

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For men & women

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107 hours

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1 test

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The Anti ds-DNA Antibody, EIA test identifies the presence of autoantibodies against double-stranded DNA (dsDNA) in the blood. It helps diagnose autoimmune disorders such as systemic lupus erythematosus (SLE) and other autoimmune-related conditions, guiding diagnosis and treatment.

Samples required

Blood

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Preparations

Overnight fasting required for 8 to 12 hours

Sample Collection

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Understanding Anti ds-DNA Antibody, EIA

Anti-dsDNA is a type of autoantibody known as antinuclear antibodies (ANA). Under normal circumstances, these antibodies help protect us from infections, but autoantibodies are produced when the immune system confuses the body’s own cells with foreign invaders. This leads to the immune system mistakenly attacking healthy cells, causing autoimmune disorders. While low levels of anti-dsDNA can be found in several conditions, it is mainly linked to systemic lupus erythematosus (SLE), a long-term inflammatory autoimmune disease affecting kidneys, joints, blood vessels, skin, heart, lungs, and brain. The Anti ds-DNA Antibody, EIA test can help diagnose lupus and differentiate it from other autoimmune disorders such as mixed connective tissue disease and lupus nephritis.

The doctor may suggest the Anti ds-DNA Antibody, EIA test if the individual has a positive antinuclear antibody (ANA) test along with symptoms suggestive of lupus, such as persistent fatigue, joint pain, and a characteristic butterfly-shaped rash across the nose and cheeks. It is also periodically used to assess disease activity in people who have already been diagnosed with lupus and if there are risk factors such as aging, obesity, and a family history of autoimmune diseases.

Generally, an overnight fast (8-12 hours) is preferred but not mandatory for this test. However, it's advised to inform the doctor about any other medications or supplements being taken, as certain medications may affect the test results. Additionally, telling a detailed medical history and discussing symptoms can help the doctor correlate the clinical and laboratory findings.

Lab test results may vary across laboratories based on the methodologies used and reference ranges. The Anti ds-DNA Antibody, EIA test conducted through the enzyme-linked immunosorbent assay (EIA) method is one of the most sensitive screening tests for detecting even subtle levels of ds-DNA. This method uses enzymes to find the antibodies in the blood. It is a faster and more automated method.

Do not try to self-medicate at home based solely on these results. Always consult a doctor for a proper understanding of the test results. The insights from this test help the doctor tailor appropriate treatment plans.

What does Anti ds-DNA Antibody, EIA measure?

The Anti ds-DNA Antibody, EIA test assesses the presence of autoantibodies (antibodies that attack the body's own cells) against double-stranded DNA (ds-DNA), which are closely associated with autoimmune activity, particularly in systemic lupus erythematosus (SLE). By detecting whether these autoantibodies are present in the blood, the test provides valuable insights into the immune system's behavior. A positive result suggests an abnormal immune response that may be targeting the body's own DNA, indicating a potential autoimmune disorder. This test helps doctors evaluate the likelihood of SLE and other related conditions, guiding further diagnostic and treatment decisions.

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FAQs related to Anti ds-DNA Antibody, EIA

What is the Anti ds-DNA Antibody, EIA test?

The Anti ds-DNA Antibody, EIA test detects antibodies that specifically target double-stranded DNA in the blood. It is primarily used to diagnose and monitor systemic lupus erythematosus (SLE) and other autoimmune disorders.

Why would my doctor order the Anti ds-DNA Antibody, EIA test?

Your doctor may recommend this test if you exhibit symptoms such as joint pain, fatigue, skin rashes, or kidney issues that could indicate an autoimmune disease like lupus. It is also useful for tracking disease activity.

How is the test performed?

The test involves a simple blood draw. A healthcare expert will take a sample of your blood, which will then be tested using the enzyme-linked immunosorbent assay (ELISA) method to check for anti-dsDNA antibodies.

Do I need to prepare for the test?

No special preparation is required for the Anti ds-DNA Antibody, EIA test. However, it's important to inform your doctor about any medications or supplements you are taking, as these may affect the test results.

What do the results mean?

A positive result indicates the presence of anti-dsDNA antibodies, which may suggest an autoimmune disorder, particularly lupus. However, results should be interpreted in the context of other clinical findings and symptoms by doctors. A negative result suggests lupus is less likely, though it doesn't completely rule out autoimmune conditions, as some lupus patients may not have detectable anti-dsDNA antibodies. Your doctor will assess all symptoms and test results for an accurate diagnosis.

Are there any risks associated with the test?

No, there is no risk associated with Anti ds-DNA Antibody, EIA test. However, some individuals may feel a slight sting when a needle is pricked and experience some bleeding that is normal and usually not bothersome. Rarely, some individuals may also experience slight swelling or bruising at the site of the needle prick. Applying ice 3-4 times a day for about a week may help reduce swelling and bruising. If the condition persists, seek advice from your doctor.

Can I have this test if I’m pregnant?

Yes, the Anti ds-DNA Antibody, EIA test can be performed during pregnancy if deemed necessary by your doctor. However, it’s essential to discuss any concerns with your doctor.

How often should I be tested?

The frequency of testing depends on your individual health status, symptoms, and whether you have a diagnosed autoimmune disorder. Your doctor will determine the appropriate schedule based on your specific situation.

Can I get the Anti ds-DNA Antibody, EIA at home?

Yes. Tata 1 mg Labs offers a safe and hygienic sample collection facility from the comfort of your home.

If my Anti ds-DNA Antibody, EIA test results are abnormal, what additional tests might my doctor recommend?

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

3rd Nov 2025