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Allergy Screen, Total IgE and Phadia Top (Adult & >5yr)

Also referred as

Allergy Screening IgE With Phadiatop (Adult & >5y)

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The Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) is a screening test that helps in the diagnosis of Atopy or IgE-mediated allergy in adults and children above 5 years. It measures Total IgE (antibodies produced by the immune system in response to allergens) and specialized Phadiatop IgE which is an ImmunoCAP with a well-balanced mix of representative allergens including inhalant allergens like dust, pollen, animal dander, grass, weed, etc., present in the air. The Phadiatop IgE levels if high confirm an allergy, but cannot specify the allergens causing the allergy.

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Understanding Allergy Screen, Total IgE and Phadia Top (Adult & >5yr)

An allergy is a hypersensitivity response of the immune system that causes undesirable reactions to certain environmental substances. Such patients produce high levels of antibodies called immunoglobulin E (IgE) in response to certain allergens present in the atmosphere. The Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) is a screening test that helps in the diagnosis of Atopy or IgE-mediated allergy in adults and children above 5 years.

Your doctor may suggest the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test if you have sneezing, runny nose, hives, difficulty in breathing, itching, etc. Generally, no special preparation is required for the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test. However, inform your doctor about any medications (such as antihistamines) you are taking, as they might influence your test results.

Based on the test results further specific allergen testing may be recommended. Getting tested with the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test helps in distinguishing atopic (IgE-mediated) from non-atopic (non-IgE-mediated) allergies and aids in getting appropriate treatment.

Reference ranges may vary based on factors such as age, medical history, etc. Narrate your complete medical history including any known allergies, and symptoms that can impact test interpretations to help the doctor correlate your laboratory and clinical findings and formulate a robust treatment plan.

What does Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) measure?

Contains 2 tests

It measures Total IgE (antibodies produced by the immune system in response to allergens) and specialized Phadiatop IgE using ImmunoCAP with comprehensive inhalant allergens like dust, pollen, animal dander, grass, weed, etc., present in the air.

When an allergen (allergy-causing substance) enters the body, the immune system produces immunoglobulin IgE antibodies. These are produced to fight foreign substances. and trigger the release of histamines from the cells. This causes allergic symptoms. Getting tested aids in distinguishing atopic (allergen-sensitive) from non-atopic (non-allergen-sensitive) allergies and provides appropriate treatment. With careful management and a tailored treatment plan, allergies can be effectively managed to minimize the impact on your quality of life.

Total IgE

The Total IgE (Immunoglobulin E) test is used to quantify the total level of IgE antibodies in your blood. Immunoglobulins are antibodies (proteins) secreted by plasma cells (immune cells) when the body identifies a dangerous foreign substance like bacteria, viruses, or allergens. There are five basic forms of immunoglobulins: IgA, IgG, IgM, IgD, and IgE. Of these, IgE plays a primary role in allergic reactions to allergens such as pollen, dust, pet dander, mold, latex, some foods (such as eggs, peanuts, or strawberries), or insect stings.

Unlike other antibodies, IgE is primarily associated with immune responses to allergenic substances, such as plant pollen, latex, pet dander, mold, eggs, peanuts, bee venom, and strawberries. Typically, IgE is present in tiny amounts in the blood. When the immune system encounters an allergen, it triggers the production of IgE antibodies. The Total IgE test measures the concentration of these IgE antibodies in the blood, providing insights into the presence and severity of allergies.

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Allergy Screen- Phadiatop (Adult & >5yr), ImmunoCAP

The Allergy Screen- Phadiatop (Adult & >5yr), ImmunoCAP test is a blood test designed to screen for common inhalant allergens in individuals aged five years and older. This test detects specific Immunoglobulin E (IgE) antibodies, which the immune system produces in response to inhalant allergens such as pollen, dust mites, pet dander, and mold. ImmunoCAP technology ensures high accuracy and sensitivity in identifying these antibodies, making it a reliable method for determining whether a person has an allergic predisposition.

By confirming allergic sensitization (developing IgE antibodies to inhaled allergens), the Phadiatop test helps doctors develop targeted treatment plans, including strategies to avoid specific allergens and appropriate medications. This is particularly useful as an initial screening tool, guiding further, more specific allergy testing if needed.

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FAQs related to Allergy Screen, Total IgE and Phadia Top (Adult & >5yr)

Why is the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test important?

This test is crucial for identifying potential allergies, which can cause symptoms ranging from mild (like rashes and itching) to severe (like difficulty breathing and loss of consciousness). Identifying the allergens that trigger these reactions can help manage symptoms, get appropriate treatment, and prevent serious complications.

When should I get tested with the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test?

You may get tested with the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test if you exhibit symptoms such as sneezing, itchy and watery eyes, stuffy and runny nose, hives (rashes with raised red patches), difficulty breathing, coughing, wheezing, diarrhea, vomiting, etc.

Why is the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test ordered?

The test is generally ordered when an individual exhibits symptoms of allergies, such as sneezing, runny nose, itchy eyes, and skin rashes. By measuring total IgE levels and specialized Phadiatop IgE using ImmunoCAP with comprehensive inhalant allergens like dust, pollen, animal dander, grass, weed, etc., present in the air, this test helps identify whether the symptoms are due to an allergic reaction. Based on the results, further specific allergen testing may be conducted.

How often should I get tested?

The frequency of the test depends on your individual health condition, lifestyle, and the advice of your doctor. If you have persistent allergy symptoms, your doctor might recommend testing at regular intervals. Talk to your doctor if you have persistent allergic symptoms like sneezing, runny nose, itchy eyes, skin rashes, etc.

What factors can influence the test results?

Several factors can affect the results of this test, including your age, the severity of your allergy, recent exposure to allergens, certain medications, and overall health status.

What do the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test results mean?

This test has 2 components; the first is Total IgE which is found to be high in allergies as well as other conditions like parasitic diseases etc. The second part is Phadiatop IgE. This uses an ImmunoCAP with a balanced mixture of representative allergens, including grasses, trees, weeds, cats, dogs, mites, and molds. A positive result indicates that the patient is allergic to one or more of these allergens; a negative indicates the patient is not allergic to such inhalant allergens. A positive test may prompt your doctor to advise for Immunocap Specific IgE testing against known allergens/ panels. However, it is possible to have negative results even if you are allergic to a substance. High Total IgE levels indicate an allergy. However, high Total IgE may also be raised in other conditions, such as parasitic infections. A normal or negative result means you do not have an allergy. However, it is possible to have negative results even if you are allergic to a substance. It is, therefore, crucial to consult a doctor or an allergy specialist for result interpretation.

What is the ImmunoCAP Specific IgE Blood Test?

ImmunoCAP Specific IgE Blood Test is a specialized test that can quantitatively and accurately identify specific allergen sensitivities, i.e., identify an allergy and determine the allergen (allergy-causing substance) in people with a confirmed allergy. ImmunoCAP-specific allergy tests can be done either as single tests or as part of panels. These tests are advised by doctors if your Total IgE / Phadiatop is high and the doctor suspects allergy based on clinical findings.

How can I manage my allergies if my test results are positive?

Management of allergies depends on the nature of the allergen, the severity of symptoms, and individual patient factors. Common strategies include avoiding allergen exposure, taking prescription medications to control symptoms, and immunotherapy (allergy shots or tablets) as advised by your doctor. Talk to your doctor to get the best possible advice to manage your allergies effectively.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

2nd Nov 2025