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Understanding the Test
Test Measures
Interpreting Results
FAQ's
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References
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Dr. Shreya Gupta
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Allergy Screen, Total IgE and Phadia Top (Adult & >5yr)

Also known as Allergy Screening IgE With Phadiatop (Adult & >5y)
Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) Includes 2 testsView All
13991800 22% Off
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Allergy Screen, Total IgE and Phadia Top (Adult & >5yr)


What is Allergy Screen, Total IgE and Phadia Top (Adult & >5yr)?

The Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) is a screening test that helps in the diagnosis of Atopy or IgE-mediated allergy in adults and children above 5 years. It measures Total IgE (antibodies produced by the immune system in response to allergens) and specialized Phadiatop IgE which is an ImmunoCAP with a well-balanced mix of representative allergens including inhalant allergens like dust, pollen, animal dander, grass, weed, etc., present in the air. The Phadiatop IgE levels if high confirm an allergy, but cannot specify the allergens causing the allergy.

An allergy is a hypersensitivity response of the immune system that causes undesirable reactions to certain environmental substances. Such patients produce high levels of antibodies called immunoglobulin E (IgE) in response to certain allergens present in the atmosphere. The Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) is a screening test that helps in the diagnosis of Atopy or IgE-mediated allergy in adults and children above 5 years. 

Your doctor may suggest the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test if you have sneezing, runny nose, hives, difficulty in breathing, itching, etc. Generally, no special preparation is required for the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test. However, inform your doctor about any medications (such as antihistamines) you are taking, as they might influence your test results.

Based on the test results further specific allergen testing may be recommended. Getting tested with the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test helps in distinguishing atopic (IgE-mediated) from non-atopic (non-IgE-mediated) allergies and aids in getting appropriate treatment.

Reference ranges may vary based on factors such as age, medical history, etc. Narrate your complete medical history including any known allergies, and symptoms that can impact test interpretations to help the doctor correlate your laboratory and clinical findings and formulate a robust treatment plan.

What is Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) used for?

The Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test is done: 

  • If you experience allergy symptoms such as itchy or watery eyes, swelling, shortness of breath, skin rash, congestion, hives, diarrhea, eczema, or sneezing.
  • If you have allergic asthma.
  • To track and monitor treatment progress and effectiveness.
  • In individuals with a family history of allergies.
  • In case of parasitic infection.

What does Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) measure?

Contains 2 tests

It measures Total IgE (antibodies produced by the immune system in response to allergens)  and specialized Phadiatop IgE using ImmunoCAP with comprehensive inhalant allergens like dust, pollen, animal dander, grass, weed, etc., present in the air.

When an allergen (allergy-causing substance) enters the body, the immune system produces immunoglobulin IgE antibodies. These are produced to fight foreign substances. and trigger the release of histamines from the cells. This causes allergic symptoms. Getting tested aids in distinguishing atopic (allergen-sensitive) from non-atopic (non-allergen-sensitive) allergies and provides appropriate treatment. With careful management and a tailored treatment plan, allergies can be effectively managed to minimize the impact on your quality of life.

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Total IgE

Immunoglobulins are antibodies (proteins) produced by plasma cells (specific immune cells) when the body recognizes bacteria, viruses, other microorganisms, or any other unknown substances as harmful foreign antigens (allergy-causing substances or allergens) to the immune system. There are five types of immunoglobulins: IgA, IgG, IgM, IgD, and IgE.

Unlike other antibodies, IgE is primarily associated with immune responses to allergenic substances, such as plant pollen, latex, pet dander, mold, eggs, peanuts, bee venom, and strawberries. Typically, IgE is present in tiny amounts in the blood. When the immune system encounters an allergen, it triggers the production of IgE antibodies. The Total IgE test measures the concentration of these IgE antibodies in the blood, providing insights into the presence and severity of allergies.

Know more about Total IgE

Allergy Screen- Phadiatop (Adult & >5yr), ImmunoCAP

Interpreting Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) results


Interpretations

* If your total IgE level is increased, it usually indicates that you are suffering from one or more allergies. Sometimes, increased levels are also associated with parasitic infections. * An elevated IgE indicates an allergic process but does not indicate what a person is allergic to. In general, the greater the number of things a person is allergic to, the higher is the IgE level.

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Allergy Screen, Total IgE and Phadia Top (Adult & >5yr)


Frequently Asked Questions about Allergy Screen, Total IgE and Phadia Top (Adult & >5yr)

Q. Why is the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test important?

This test is crucial for identifying potential allergies, which can cause symptoms ranging from mild (like rashes and itching) to severe (like difficulty breathing and loss of consciousness). Identifying the allergens that trigger these reactions can help manage symptoms, get appropriate treatment, and prevent serious complications.

Q. When should I get tested with the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test?

You may get tested with the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test if you exhibit symptoms such as sneezing, itchy and watery eyes, stuffy and runny nose, hives (rashes with raised red patches), difficulty breathing, coughing, wheezing, diarrhea, vomiting, etc.

Q. Why is the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test ordered?

The test is generally ordered when an individual exhibits symptoms of allergies, such as sneezing, runny nose, itchy eyes, and skin rashes. By measuring total IgE levels and specialized Phadiatop IgE using ImmunoCAP with comprehensive inhalant allergens like dust, pollen, animal dander, grass, weed, etc., present in the air, this test helps identify whether the symptoms are due to an allergic reaction. Based on the results, further specific allergen testing may be conducted.

Q. How often should I get tested?

The frequency of the test depends on your individual health condition, lifestyle, and the advice of your doctor. If you have persistent allergy symptoms, your doctor might recommend testing at regular intervals. Talk to your doctor if you have persistent allergic symptoms like sneezing, runny nose, itchy eyes, skin rashes, etc.

Q. What factors can influence the test results?

Several factors can affect the results of this test, including your age, the severity of your allergy, recent exposure to allergens, certain medications, and overall health status.

Q. What do the Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test results mean?

This test has 2 components; the first is Total IgE which is found to be high in allergies as well as other conditions like parasitic diseases etc. The second part is Phadiatop IgE. This uses an ImmunoCAP with a balanced mixture of representative allergens, including grasses, trees, weeds, cats, dogs, mites, and molds. A positive result indicates that the patient is allergic to one or more of these allergens; a negative indicates the patient is not allergic to such inhalant allergens. A positive test may prompt your doctor to advise for Immunocap Specific IgE testing against known allergens/ panels. However, it is possible to have negative results even if you are allergic to a substance. High Total IgE levels indicate an allergy. However, high Total IgE may also be raised in other conditions, such as parasitic infections. A normal or negative result means you do not have an allergy. However, it is possible to have negative results even if you are allergic to a substance. It is, therefore, crucial to consult a doctor or an allergy specialist for result interpretation.

Q. What is the ImmunoCAP Specific IgE Blood Test?

ImmunoCAP Specific IgE Blood Test is a specialized test that can quantitatively and accurately identify specific allergen sensitivities, i.e., identify an allergy and determine the allergen (allergy-causing substance) in people with a confirmed allergy. ImmunoCAP-specific allergy tests can be done either as single tests or as part of panels. These tests are advised by doctors if your Total IgE / Phadiatop is high and the doctor suspects allergy based on clinical findings.

Q. How can I manage my allergies if my test results are positive?

Management of allergies depends on the nature of the allergen, the severity of symptoms, and individual patient factors. Common strategies include avoiding allergen exposure, taking prescription medications to control symptoms, and immunotherapy (allergy shots or tablets) as advised by your doctor. Talk to your doctor to get the best possible advice to manage your allergies effectively.
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Allergy Screen, Total IgE and Phadia Top (Adult & >5yr) test price for other cities


Price inMumbaiRs. 1399
Price inBangaloreRs. 1399
Price inNew DelhiRs. 1399
Price inKolkataRs. 1399
Price inNoidaRs. 1710
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References

  1. Dougherty JM, Alsayouri K, Sadowski A. Allergy. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545237/ External Link
  2. Vidal C, Gude F, Boquete O, Fernández-Merino MC, Meijide LM, Rey J, Lojo S, González-Quintela A. Evaluation of the phadiatop test in the diagnosis of allergic sensitization in a general adult population. J Investig Allergol Clin Immunol. 2005;15(2):124-30. PMID: 16047713. [Accessed 03 Apr. 2024]. Available from: https://pubmed.ncbi.nlm.nih.gov/16047713/ External Link
  3. Chang YC, Lee TJ, Huang CC, Chang PH, Chen YW, Fu CH. The Role of Phadiatop Tests and Total Immunoglobulin E Levels in Screening Aeroallergens: A Hospital-Based Cohort Study. J Asthma Allergy. 2021 Feb 17;14:135-140. [Accessed 03 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898199/ External Link
  4. Allergens [Internet]. NIH; 07 Sep. 2022. [Accessed 03 Apr. 2024]. Available from: https://www.niehs.nih.gov/health/topics/agents/allergens/index.cfm External Link
  5. InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Allergies: Overview. [Updated 2020 Apr 23]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK447112/ External Link
  6. McLendon K, Sternard BT. Anaphylaxis. [Updated 2023 Jan 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482124/ External Link
  7. Portnoy JM. Appropriate allergy testing and interpretation. Mo Med. 2011 Sep-Oct;108(5):339-43. PMID: 22073491; PMCID: PMC6188374. [Accessed 03 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188374/ External Link
  8. Murphy PB, Atwater AR, Mueller M. Allergic Contact Dermatitis. [Updated 2023 Jul 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532866/ External Link
  9. Birch K, Pearson-Shaver AL. Allergy Testing. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537020/ External Link
  10. Sinclair D, Peters SA. The predictive value of total serum IgE for a positive allergen-specific IgE result. J Clin Pathol. 2004 Sep;57(9):956-9. [Accessed 03 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770430/External Link
  11. IgE (Total) Allergy Test [Internet]. South Tees Hospitals NHS Foundation Trust; 27 Apr. 2022. [Accessed 03 Apr. 2024]. Available from: https://www.southtees.nhs.uk/services/pathology/tests/ige-total-allergy-test/External Link
  12. Chang ML, Cui C, Liu YH, Pei LC, Shao B. Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomedical Reports. 2015;3(4):573-577. [Accessed 03 Apr. 2024]. Available from: https://doi.org/10.3892/br.2015.455External Link

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