Anti Cyclic Citrullinated Peptide Antibody
What is Anti CCP?
Anti cyclic citrullinated peptide antibody (CCP) is an antibody which is found in the patients of rheumatoid arthritis. This test detects the levels of anti CCP antibody in the blood. This test is also known as citrulline antibody test, the anti-citrulline antibody test, CCP antibody test. It helps in differentiating rheumatoid arthritis from other types of arthritis.
Why is Anti CCP done?
To diagnose rheumatoid arthritis
To differentiate rheumatoid arthritis from other arthritis
To evaluate the prognosis of the patient with rheumatoid arthritis
What does Anti CCP Measure?
Anti cyclic citrullinated peptide antibodies are autoantibodies which are produced by the immune system that attack against the cyclic citrullinated peptide. Due to these attacks, inflammatory symptoms are produced in the body which is most commonly seen in rheumatoid arthritis. The Anti CCP antibodies can be present in patients prior to the start of symptoms of rheumatoid arthritis. The presence of positive Anti CCP antibodies in rheumatoid arthritis patients is said to be due to the combination of genetics and environmental factors. These patients have a common sequence of amino acids which is called as shared epitope that is encoded in specific genetic markers called human leukocyte antigens (HLA) which are responsible for producing proteins to control immune responses. The shared epitope attaches to these proteins to produce Anti CCP antibodies.
Interpreting Anti CCP results
Anti CCP antibody test positivity indicates Rheumatoid Arthritis