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Coombs Test - Direct

Coombs Test - Direct near me in Ahmedabad

Also referred as
Direct Antiglobulin Test (DAT)
Coombs Direct
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The Coombs Test - Direct is a blood test used to detect antibodies or complement proteins attached to the surface of red blood cells (RBCs). This test helps diagnose conditions where the immune system attacks RBCs, such as autoimmune hemolytic anemia (AIHA), and monitor potential blood compatibility issues during transfusions. It is crucial for identifying causes of hemolysis, especially in newborns and individuals with autoimmune diseases.

The Direct Coombs Test plays a critical role in managing hemolytic disease of the newborn (HDN) by detecting maternal antibodies that might have crossed the placenta leading to the destruction of the baby’s RBCs. This test also helps  in investigating transfusion reactions by detecting antibodies attacking transfused RBCs if a patient receives a blood transfusion and the immune system reacts to the donor blood. 

No special preparation is needed for this test. You may eat and drink as per your daily routine. 

 

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Understanding Coombs Test - Direct

The Coombs Test - Direct, also known as the Direct Antiglobulin Test (DAT), helps diagnose various conditions in which the body’s immune system mistakenly targets and attacks its own red blood cells, leading to their premature destruction (hemolysis). 

Unlike the Indirect Coombs Test, which looks for free-floating antibodies in the blood, the direct version focuses on antibodies already attached to RBCs. This makes it particularly useful in diagnosing autoimmune hemolytic anemia (AIHA), where the immune system mistakenly identifies RBCs as foreign substances and attacks them. These antibodies (also called autoantibodies) can cause the RBCs to break apart, leading to symptoms such as fatigue, jaundice, and anemia.

The Coombs Test - Direct plays a critical role in managing hemolytic disease of the newborn (HDN) by detecting maternal antibodies that might have crossed the placenta, leading to the destruction of the baby’s RBCs. This test also investigates transfusion reactions by detecting antibodies that attack the transfused red blood cells if a patient receives a blood transfusion and the immune system reacts to the donor blood. This test also investigates transfusion reactions by detecting antibodies that attack the transfused red blood cells if a patient’s immune system reacts to the donated blood.

It is also used to assess drug-induced hemolytic anemia, a condition in which certain medications can trigger the immune system to target red blood cells, often resulting in anemia and other symptoms related to hemolysis.

No special preparation is required for this test. Inform the doctor about all the medications or supplements being taken, as these could affect the test results, potentially requiring dosage adjustments or temporary discontinuation before the test. 

Lab test results may vary across laboratories. Interpretation of the test results requires professional expertise. Therefore, do not self-medicate. Always consult the doctor to understand the test results correctly. 

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What does Coombs Test - Direct measure?

The Coombs Test - Direct measures the presence of antibodies or complement proteins already attached to the surface of red blood cells. These antibodies are produced by the immune system in response to what it perceives as foreign antigens. A positive result suggests the presence of autoantibodies, indicating that the body is attacking its own red blood cells.

This test is crucial for diagnosing conditions like autoimmune hemolytic anemia, where the immune system targets RBCs, causing their premature destruction. By identifying these antibodies early, doctors can formulate appropriate treatment plans, especially in cases where transfusion reactions or hemolytic disease of the newborn are of concern.

FAQs related to Coombs Test - Direct in Ahmedabad

The Coombs Test - Direct, also known as the Direct Antiglobulin Test (DAT), is a blood test that detects antibodies or complement proteins attached to the surface of red blood cells. It helps diagnose conditions like autoimmune hemolytic anemia and hemolytic disease of the newborn (HDN).
Your doctor may recommend this test if you have symptoms of anemia, unexplained jaundice, or hemolysis (breakdown of red blood cells). It is also used to monitor autoimmune disorders, assess transfusion reactions, and detect blood compatibility issues during pregnancy.
The test involves mixing a blood sample with a special gel containing anti-human globulin. If antibodies attach to the red blood cells, they will form clumps within the gel. This clumping is then detected under a microscope.
No special preparation is needed for the Coombs Test - Direct. However, inform your doctor about any medications or supplements you are taking, as some drugs may affect the results
Yes. In Ahmedabad, you can schedule the Coombs Test - Direct near you with Tata 1mg Labs. The test is easy to book, cost-effective, and available with a comprehensive report.
Yes, home sample collection for the Coombs Test - Direct is readily available in Ahmedabad. Tata 1mg Labs allows you to choose a date and time that suits your schedule for sample collection.
If you want to schedule the Coombs Test - Direct with Tata 1mg Labs in Ahmedabad, the procedure is fairly easy and hassle-free. Follow these steps to book a test: 1). Visit the Lab Tests section on the Tata 1mg website. 2). Add the test you want in the cart. 3). Pick a time and date slot according to your convenience; however, do consider the necessary prerequisites while scheduling a test. 4). You will receive a notification with all the details once the test is scheduled.
Tata 1mg Labs is a pocket-friendly platform for booking lab tests in Ahmedabad. The Coombs Test - Direct is available at an affordable price of Rs. 500.
At Tata 1mg Labs, we understand the importance of timely results. We strive to provide fast turnaround times for test results, allowing you to get the information you need promptly. On average, we take 48 hours to provide the reports of the Coombs Test - Direct in Ahmedabad.
Content created by
Written by:
Dr. Lipika Khurana
BDS, PGDHHM
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated7th Oct 2025

Coombs Test - Direct test price for other cities

Price inNew DelhiRs. 469
Price inKolkataRs. 469
Price inGurgaonRs. 469
Price inBangaloreRs. 619
Price inHyderabadRs. 399

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